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Safety and Efficacy of Percutaneous Liver Microwave Ablation Using a Fully Water-Cooled Choke Ring Antenna: First Multicenter Clinical Report

INTRODUCTION: The safety and efficacy of a microwave ablation (MWA) system for the liver with novel technologies in field control, antenna cooling through the inner part of the choke ring, and dual temperature monitoring were evaluated in this multicenter retrospective study. MATERIAL AND METHODS: A...

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Autores principales: Blain, Maxime, Narayanan, Govindarajan, Ricoeur, Alexis, Kobe, Adrian, Mahendra, Ashwin M., Jacks, Blake, Letty, Quentin, Bonnet, Baptiste, Tselikas, Lambros, Deschamps, Frederic, de Baère, Thierry
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10382338/
https://www.ncbi.nlm.nih.gov/pubmed/37430015
http://dx.doi.org/10.1007/s00270-023-03481-3
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author Blain, Maxime
Narayanan, Govindarajan
Ricoeur, Alexis
Kobe, Adrian
Mahendra, Ashwin M.
Jacks, Blake
Letty, Quentin
Bonnet, Baptiste
Tselikas, Lambros
Deschamps, Frederic
de Baère, Thierry
author_facet Blain, Maxime
Narayanan, Govindarajan
Ricoeur, Alexis
Kobe, Adrian
Mahendra, Ashwin M.
Jacks, Blake
Letty, Quentin
Bonnet, Baptiste
Tselikas, Lambros
Deschamps, Frederic
de Baère, Thierry
author_sort Blain, Maxime
collection PubMed
description INTRODUCTION: The safety and efficacy of a microwave ablation (MWA) system for the liver with novel technologies in field control, antenna cooling through the inner part of the choke ring, and dual temperature monitoring were evaluated in this multicenter retrospective study. MATERIAL AND METHODS: Ablation characteristics and efficacy were assessed on follow-up imaging (computed tomography or magnetic resonance imaging). Safety was evaluated according to CTCAE classification. RESULTS: Eighty-seven liver tumors (65 metastases and 22 hepatocellular carcinomas) measuring 17.8 ± 7.9 mm were treated in 68 patients. Ablation zones measured 35.6 ± 11 mm in longest diameter. The coefficients of variation of the longest and shortest ablation diameters were 30.1% and 26.4%, respectively. The mean sphericity index of the ablation zone was 0.78 ± 0.14. Seventy-one ablations (82%) had a sphericity index above 0.66. At 1 month, all tumors demonstrated complete ablation with margins of 0–5 mm, 5–10 mm, and greater than 10 mm achieved in 22%, 46%, and 31% of tumors, respectively. After a median follow-up of 10 months, local tumor control was achieved in 84.7% of treated tumors after a single ablation and in 86% after one patient received a second ablation. One grade 3 complication (stress ulcer) occurred, but was unrelated to the procedure. Ablation zone size and geometry in this clinical study were in accordance with previously reported in vivo preclinical findings. CONCLUSION: Promising results were reported for this MWA device. The high spherical index, reproducibility, and predictability of the resulting treatment zones translated to a high percentage of adequate safety margins, providing good local control rate.
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spelling pubmed-103823382023-07-30 Safety and Efficacy of Percutaneous Liver Microwave Ablation Using a Fully Water-Cooled Choke Ring Antenna: First Multicenter Clinical Report Blain, Maxime Narayanan, Govindarajan Ricoeur, Alexis Kobe, Adrian Mahendra, Ashwin M. Jacks, Blake Letty, Quentin Bonnet, Baptiste Tselikas, Lambros Deschamps, Frederic de Baère, Thierry Cardiovasc Intervent Radiol Technical Note INTRODUCTION: The safety and efficacy of a microwave ablation (MWA) system for the liver with novel technologies in field control, antenna cooling through the inner part of the choke ring, and dual temperature monitoring were evaluated in this multicenter retrospective study. MATERIAL AND METHODS: Ablation characteristics and efficacy were assessed on follow-up imaging (computed tomography or magnetic resonance imaging). Safety was evaluated according to CTCAE classification. RESULTS: Eighty-seven liver tumors (65 metastases and 22 hepatocellular carcinomas) measuring 17.8 ± 7.9 mm were treated in 68 patients. Ablation zones measured 35.6 ± 11 mm in longest diameter. The coefficients of variation of the longest and shortest ablation diameters were 30.1% and 26.4%, respectively. The mean sphericity index of the ablation zone was 0.78 ± 0.14. Seventy-one ablations (82%) had a sphericity index above 0.66. At 1 month, all tumors demonstrated complete ablation with margins of 0–5 mm, 5–10 mm, and greater than 10 mm achieved in 22%, 46%, and 31% of tumors, respectively. After a median follow-up of 10 months, local tumor control was achieved in 84.7% of treated tumors after a single ablation and in 86% after one patient received a second ablation. One grade 3 complication (stress ulcer) occurred, but was unrelated to the procedure. Ablation zone size and geometry in this clinical study were in accordance with previously reported in vivo preclinical findings. CONCLUSION: Promising results were reported for this MWA device. The high spherical index, reproducibility, and predictability of the resulting treatment zones translated to a high percentage of adequate safety margins, providing good local control rate. Springer US 2023-07-10 2023 /pmc/articles/PMC10382338/ /pubmed/37430015 http://dx.doi.org/10.1007/s00270-023-03481-3 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Technical Note
Blain, Maxime
Narayanan, Govindarajan
Ricoeur, Alexis
Kobe, Adrian
Mahendra, Ashwin M.
Jacks, Blake
Letty, Quentin
Bonnet, Baptiste
Tselikas, Lambros
Deschamps, Frederic
de Baère, Thierry
Safety and Efficacy of Percutaneous Liver Microwave Ablation Using a Fully Water-Cooled Choke Ring Antenna: First Multicenter Clinical Report
title Safety and Efficacy of Percutaneous Liver Microwave Ablation Using a Fully Water-Cooled Choke Ring Antenna: First Multicenter Clinical Report
title_full Safety and Efficacy of Percutaneous Liver Microwave Ablation Using a Fully Water-Cooled Choke Ring Antenna: First Multicenter Clinical Report
title_fullStr Safety and Efficacy of Percutaneous Liver Microwave Ablation Using a Fully Water-Cooled Choke Ring Antenna: First Multicenter Clinical Report
title_full_unstemmed Safety and Efficacy of Percutaneous Liver Microwave Ablation Using a Fully Water-Cooled Choke Ring Antenna: First Multicenter Clinical Report
title_short Safety and Efficacy of Percutaneous Liver Microwave Ablation Using a Fully Water-Cooled Choke Ring Antenna: First Multicenter Clinical Report
title_sort safety and efficacy of percutaneous liver microwave ablation using a fully water-cooled choke ring antenna: first multicenter clinical report
topic Technical Note
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10382338/
https://www.ncbi.nlm.nih.gov/pubmed/37430015
http://dx.doi.org/10.1007/s00270-023-03481-3
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