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Cardiovascular complications are resolved by tuna protein hydrolysate supplementation in rats fed with a high-fat diet
This study is aimed to investigate whether tuna protein hydrolysate (TPH) supplementation could alleviate cardiovascular complications induced by a high-fat diet (HFD) in rats. Rats were fed a HFD for 16 weeks and given TPH (100 mg/kg, 300 mg/kg, or 500 mg/kg) or metformin (100 mg/kg) (n = 8) for th...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10382531/ https://www.ncbi.nlm.nih.gov/pubmed/37507421 http://dx.doi.org/10.1038/s41598-023-39538-z |
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author | Maneesai, Putcharawipa Wattanathorn, Jintanaporn Potue, Prapassorn Khamseekaew, Juthamas Rattanakanokchai, Siwayu Thukham-Mee, Wipawee Muchimapura, Supaporn Pakdeechote, Poungrat |
author_facet | Maneesai, Putcharawipa Wattanathorn, Jintanaporn Potue, Prapassorn Khamseekaew, Juthamas Rattanakanokchai, Siwayu Thukham-Mee, Wipawee Muchimapura, Supaporn Pakdeechote, Poungrat |
author_sort | Maneesai, Putcharawipa |
collection | PubMed |
description | This study is aimed to investigate whether tuna protein hydrolysate (TPH) supplementation could alleviate cardiovascular complications induced by a high-fat diet (HFD) in rats. Rats were fed a HFD for 16 weeks and given TPH (100 mg/kg, 300 mg/kg, or 500 mg/kg) or metformin (100 mg/kg) (n = 8) for the last four weeks. TPH had the following effects: resolved their impaired glucose tolerance, hyperglycemia, dyslipidemia, obesity, and hypertension (p < 0.05); alleviated left ventricular dysfunction and hypertrophy (p < 0.05), and vascular dysfunction and hypertrophy (p < 0.05); adipocyte hypertrophy; increases in circulating leptin and tumor necrosis factor (TNF-α) were mitigated (p < 0.05); increased renin-angiotensin system (RAS), oxidative stress, and decreased nitric oxide metabolites were modulated (p < 0.05). TPH restored the expression of angiotensin II receptor type 1 (AT1R)/NADPH oxidase 2 (NOX2), endothelial nitric oxide synthase (eNOS), nuclear factor erythroid 2-related factor (Nrf2)/heme oxygenase-1 (HO-1), and peroxisome proliferator-activated receptor γ (PPARγ)/the nuclear factor kappa B (NF-κB) protein in cardiovascular tissue (p < 0.05). In metabolic syndrome (MS) rats, metformin and TPH had comparable effects. In conclusion, TPH alleviated cardiovascular complications related to MS. It suppressed RAS, oxidative stress, and inflammation that were associated with modulation of AT1R/NOX2, eNOS, Nrf2/HO-1, and PPARγ/NF-κB expression. |
format | Online Article Text |
id | pubmed-10382531 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-103825312023-07-30 Cardiovascular complications are resolved by tuna protein hydrolysate supplementation in rats fed with a high-fat diet Maneesai, Putcharawipa Wattanathorn, Jintanaporn Potue, Prapassorn Khamseekaew, Juthamas Rattanakanokchai, Siwayu Thukham-Mee, Wipawee Muchimapura, Supaporn Pakdeechote, Poungrat Sci Rep Article This study is aimed to investigate whether tuna protein hydrolysate (TPH) supplementation could alleviate cardiovascular complications induced by a high-fat diet (HFD) in rats. Rats were fed a HFD for 16 weeks and given TPH (100 mg/kg, 300 mg/kg, or 500 mg/kg) or metformin (100 mg/kg) (n = 8) for the last four weeks. TPH had the following effects: resolved their impaired glucose tolerance, hyperglycemia, dyslipidemia, obesity, and hypertension (p < 0.05); alleviated left ventricular dysfunction and hypertrophy (p < 0.05), and vascular dysfunction and hypertrophy (p < 0.05); adipocyte hypertrophy; increases in circulating leptin and tumor necrosis factor (TNF-α) were mitigated (p < 0.05); increased renin-angiotensin system (RAS), oxidative stress, and decreased nitric oxide metabolites were modulated (p < 0.05). TPH restored the expression of angiotensin II receptor type 1 (AT1R)/NADPH oxidase 2 (NOX2), endothelial nitric oxide synthase (eNOS), nuclear factor erythroid 2-related factor (Nrf2)/heme oxygenase-1 (HO-1), and peroxisome proliferator-activated receptor γ (PPARγ)/the nuclear factor kappa B (NF-κB) protein in cardiovascular tissue (p < 0.05). In metabolic syndrome (MS) rats, metformin and TPH had comparable effects. In conclusion, TPH alleviated cardiovascular complications related to MS. It suppressed RAS, oxidative stress, and inflammation that were associated with modulation of AT1R/NOX2, eNOS, Nrf2/HO-1, and PPARγ/NF-κB expression. Nature Publishing Group UK 2023-07-28 /pmc/articles/PMC10382531/ /pubmed/37507421 http://dx.doi.org/10.1038/s41598-023-39538-z Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Maneesai, Putcharawipa Wattanathorn, Jintanaporn Potue, Prapassorn Khamseekaew, Juthamas Rattanakanokchai, Siwayu Thukham-Mee, Wipawee Muchimapura, Supaporn Pakdeechote, Poungrat Cardiovascular complications are resolved by tuna protein hydrolysate supplementation in rats fed with a high-fat diet |
title | Cardiovascular complications are resolved by tuna protein hydrolysate supplementation in rats fed with a high-fat diet |
title_full | Cardiovascular complications are resolved by tuna protein hydrolysate supplementation in rats fed with a high-fat diet |
title_fullStr | Cardiovascular complications are resolved by tuna protein hydrolysate supplementation in rats fed with a high-fat diet |
title_full_unstemmed | Cardiovascular complications are resolved by tuna protein hydrolysate supplementation in rats fed with a high-fat diet |
title_short | Cardiovascular complications are resolved by tuna protein hydrolysate supplementation in rats fed with a high-fat diet |
title_sort | cardiovascular complications are resolved by tuna protein hydrolysate supplementation in rats fed with a high-fat diet |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10382531/ https://www.ncbi.nlm.nih.gov/pubmed/37507421 http://dx.doi.org/10.1038/s41598-023-39538-z |
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