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Subunit gating resulting from individual protonation events in Kir2 channels

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Inwardly rectifying potassium (Kir) channels open at the ‘helix bundle crossing’ (HBC), formed by the M2 helices at the cytoplasmic end of the transmembrane pore. Introduced negative charges at the HBC (G178D) in Kir2.2 channels forces opening, allowing pore wetting and free movement of permeant ion...

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Detalles Bibliográficos
Autores principales:	Maksaev, Grigory, Bründl-Jirout, Michael, Stary-Weinzinger, Anna, Zangerl-Plessl, Eva-Maria, Lee, Sun-Joo, Nichols, Colin G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10382558/ https://www.ncbi.nlm.nih.gov/pubmed/37507406 http://dx.doi.org/10.1038/s41467-023-40058-7

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