Computational modeling and synthesis of pyridine variants of benzoyl-phenoxy-acetamide with high glioblastoma cytotoxicity and brain tumor penetration

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Glioblastomas are highly aggressive brain tumors for which therapeutic options are very limited. In a quest for new anti-glioblastoma drugs, we focused on specific structural modifications to the benzoyl-phenoxy-acetamide (BPA) structure present in a common lipid-lowering drug, fenofibrate, and in o...

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Detalles Bibliográficos
Autores principales: Ingraham, Charles H., Stalinska, Joanna, Carson, Sean C., Colley, Susan B., Rak, Monika, Lassak, Adam, Peruzzi, Francesca, Reiss, Krzysztof, Jursic, Branko S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10382599/
https://www.ncbi.nlm.nih.gov/pubmed/37507404
http://dx.doi.org/10.1038/s41598-023-39236-w
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