Glucocorticoid enhances presenilin1-dependent Aβ production at ER’s mitochondrial-associated membrane by downregulating Rer1 in neuronal cells

Stress-induced release of glucocorticoid is an important amyloidogenic factor that upregulates amyloid precursor protein (APP) and β secretase 1 (BACE1) levels. Glucocorticoid also contributes to the pathogenesis of Alzheimer’s disease (AD) by increasing ER-mitochondria connectivity, in which amyloi...

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Detalles Bibliográficos
Autores principales: Choi, Gee Euhn, Park, Ji Yong, Park, Mo Ran, Yoon, Jee Hyeon, Han, Ho Jae
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10382667/
https://www.ncbi.nlm.nih.gov/pubmed/37494768
http://dx.doi.org/10.1016/j.redox.2023.102821

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10382667/
https://www.ncbi.nlm.nih.gov/pubmed/37494768
http://dx.doi.org/10.1016/j.redox.2023.102821

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