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Glucocorticoid enhances presenilin1-dependent Aβ production at ER’s mitochondrial-associated membrane by downregulating Rer1 in neuronal cells
Stress-induced release of glucocorticoid is an important amyloidogenic factor that upregulates amyloid precursor protein (APP) and β secretase 1 (BACE1) levels. Glucocorticoid also contributes to the pathogenesis of Alzheimer’s disease (AD) by increasing ER-mitochondria connectivity, in which amyloi...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10382667/ https://www.ncbi.nlm.nih.gov/pubmed/37494768 http://dx.doi.org/10.1016/j.redox.2023.102821 |