Cataract-causing Y204X mutation of crystallin protein CRYβB1 promotes its C-terminal degradation and higher-order oligomerization

Crystallin proteins are a class of main structural proteins of the vertebrate eye lens, and their solubility and stability directly determine transparency and refractive power of the lens. Mutation in genes that encode these crystallin proteins is the most common cause for congenital cataracts. Desp...

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Detalles Bibliográficos
Autores principales: Jing, Xuping, Zhu, Mingwei, Lu, Xiaoyun, Wei, Ping, Shi, Lingyu, Zhang, Bu-Yu, Xu, Yi, Tang, Ya-Ping, Xiang, Dao-Man, Gong, Peng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10382669/
https://www.ncbi.nlm.nih.gov/pubmed/37356717
http://dx.doi.org/10.1016/j.jbc.2023.104953

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