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Daily Δ(9)-Tetrahydrocannabinol and Withdrawal Increase Dopamine D(1)-D(2) Receptor Heteromer to Mediate Anhedonia- and Anxiogenic-like Behavior Through a Dynorphin and Kappa Opioid Receptor Mechanism

BACKGROUND: Frequent cannabis use is associated with a higher risk of developing cannabis use disorder and other adverse consequences. However, rodent models studying the underlying mechanisms of the reinforcing and withdrawal effects of the primary constituent of cannabis, Δ(9)-tetrahydrocannabinol...

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Detalles Bibliográficos
Autores principales:	Hasbi, Ahmed, Madras, Bertha K., George, Susan R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Archival Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10382712/ https://www.ncbi.nlm.nih.gov/pubmed/37519471 http://dx.doi.org/10.1016/j.bpsgos.2022.07.003

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