Acute-Onset Multifocal Hand Dysfunction Due to Alkaptonuria

Alkaptonuria is a rare metabolic disorder characterized by the accumulation of homogentisic acid. Its effects on the central nervous system are well-recognized; however, cases of pathologic homogentisic acid deposition in the peripheral nervous system are less well-described. We report the case of a...

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Detalles Bibliográficos
Autores principales: Sivakumar, Brahman Shankar, Gia An, Vincent Vin, Stewart, Nicholas, Manoharan, Shobhan, Graham, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10382865/
https://www.ncbi.nlm.nih.gov/pubmed/37521546
http://dx.doi.org/10.1016/j.jhsg.2022.10.018
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author Sivakumar, Brahman Shankar
Gia An, Vincent Vin
Stewart, Nicholas
Manoharan, Shobhan
Graham, David
author_facet Sivakumar, Brahman Shankar
Gia An, Vincent Vin
Stewart, Nicholas
Manoharan, Shobhan
Graham, David
author_sort Sivakumar, Brahman Shankar
collection PubMed
description Alkaptonuria is a rare metabolic disorder characterized by the accumulation of homogentisic acid. Its effects on the central nervous system are well-recognized; however, cases of pathologic homogentisic acid deposition in the peripheral nervous system are less well-described. We report the case of a 72-year-old man with a prior history of alkaptonuria presenting with bilateral carpal tunnel and left-sided cubital tunnel symptoms. This case is of note because the patient demonstrated a rapid onset of symptoms due to pathology at multiple foci.
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spelling pubmed-103828652023-07-30 Acute-Onset Multifocal Hand Dysfunction Due to Alkaptonuria Sivakumar, Brahman Shankar Gia An, Vincent Vin Stewart, Nicholas Manoharan, Shobhan Graham, David J Hand Surg Glob Online Case Report Alkaptonuria is a rare metabolic disorder characterized by the accumulation of homogentisic acid. Its effects on the central nervous system are well-recognized; however, cases of pathologic homogentisic acid deposition in the peripheral nervous system are less well-described. We report the case of a 72-year-old man with a prior history of alkaptonuria presenting with bilateral carpal tunnel and left-sided cubital tunnel symptoms. This case is of note because the patient demonstrated a rapid onset of symptoms due to pathology at multiple foci. Elsevier 2023-05-02 /pmc/articles/PMC10382865/ /pubmed/37521546 http://dx.doi.org/10.1016/j.jhsg.2022.10.018 Text en © 2022 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Case Report
Sivakumar, Brahman Shankar
Gia An, Vincent Vin
Stewart, Nicholas
Manoharan, Shobhan
Graham, David
Acute-Onset Multifocal Hand Dysfunction Due to Alkaptonuria
title Acute-Onset Multifocal Hand Dysfunction Due to Alkaptonuria
title_full Acute-Onset Multifocal Hand Dysfunction Due to Alkaptonuria
title_fullStr Acute-Onset Multifocal Hand Dysfunction Due to Alkaptonuria
title_full_unstemmed Acute-Onset Multifocal Hand Dysfunction Due to Alkaptonuria
title_short Acute-Onset Multifocal Hand Dysfunction Due to Alkaptonuria
title_sort acute-onset multifocal hand dysfunction due to alkaptonuria
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10382865/
https://www.ncbi.nlm.nih.gov/pubmed/37521546
http://dx.doi.org/10.1016/j.jhsg.2022.10.018
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