Progressive disruption of hematopoietic architecture from clonal hematopoiesis to MDS

Clonal hematopoiesis of indeterminate potential (CHIP) describes the age-related acquisition of somatic mutations in hematopoietic stem/progenitor cells (HSPC) leading to clonal blood cell expansion. Although CHIP mutations drive myeloid malignancies like myelodysplastic syndromes (MDS) it is unknow...

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Detalles Bibliográficos
Autores principales: Buck, Michèle C., Bast, Lisa, Hecker, Judith S., Rivière, Jennifer, Rothenberg-Thurley, Maja, Vogel, Luisa, Wang, Dantong, Andrä, Immanuel, Theis, Fabian J., Bassermann, Florian, Metzeler, Klaus H., Oostendorp, Robert A.J., Marr, Carsten, Götze, Katharina S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10382887/
https://www.ncbi.nlm.nih.gov/pubmed/37520699
http://dx.doi.org/10.1016/j.isci.2023.107328

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