Human aromatic amino acid decarboxylase is an asymmetric and flexible enzyme: Implication in aromatic amino acid decarboxylase deficiency

Human aromatic amino acid decarboxylase (AADC) is a pyridoxal 5′‐phosphate‐dependent enzyme responsible for the biosynthesis of dopamine and serotonin, essential neurotransmitters involved in motor and cognitive abilities. Mutations in its gene lead to AADC deficiency, a monogenic rare neurometaboli...

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Detalles Bibliográficos
Autores principales: Bisello, Giovanni, Ribeiro, Rui P., Perduca, Massimiliano, Belviso, Benny Danilo, Polverino de' Laureto, Patrizia, Giorgetti, Alejandro, Caliandro, Rocco, Bertoldi, Mariarita
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2023
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10382914/
https://www.ncbi.nlm.nih.gov/pubmed/37466248
http://dx.doi.org/10.1002/pro.4732

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