Reduction-responsive nucleic acid nanocarrier-mediated miR-22 inhibition of PI3K/AKT pathway for the treatment of patient-derived tumor xenograft osteosarcoma

miRNAs are important regulators of gene expression and play key roles in the development of cancer, including osteosarcoma. During the development of osteosarcoma, the expression of miR-22 is significantly downregulated, making miR-22 as a promising therapeutic target against osteosarcoma. To design...

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Detalles Bibliográficos
Autores principales: Chen, Dafu, Lei, Chengyue, Liu, Weifeng, Shao, Meiyu, Sun, Meizhou, Guo, Jianxun, Cao, Jingjing, Nie, Jing-Jun, Luo, Peng, Luo, Yuwen, Yu, Bingran, Wang, Renxian, Duan, Shun, Xu, Fu-Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: KeAi Publishing 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10382964/
https://www.ncbi.nlm.nih.gov/pubmed/37519923
http://dx.doi.org/10.1016/j.bioactmat.2023.05.012

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