Cargando…
Incidence of Neonatal Seizures in China Based on Electroencephalogram Monitoring in Neonatal Neurocritical Care Units
IMPORTANCE: Neonatal seizures pose a significant challenge in critical care, and continuous video electroencephalography (cEEG) monitoring holds promise for early detection of seizures. However, large-scale data on the incidence of neonatal seizures and monitoring systems in China are lacking. OBJEC...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Medical Association
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10383014/ https://www.ncbi.nlm.nih.gov/pubmed/37505497 http://dx.doi.org/10.1001/jamanetworkopen.2023.26301 |
_version_ | 1785080802454798336 |
---|---|
author | Yan, Kai Cheng, Guoqiang Zhou, Wei Xiao, Feifan Zhang, Chongfan Wang, Laishuan Zhang, Peng Lu, Chunmei Kong, Yanting Wang, Xinhua Zhou, Yuanfeng Lu, Weineng Tang, Juan Song, Xiaoyan Wei, Qiufen Meng, Danhua Yao, Liping Zhuang, Deyi Qu, Liuhong Xu, Qinghuo Yin, Zhaoqing Su, Le Wan, Jing Si, Yuan Fujioka, Kazumichi Mussap, Michele Kanungo, Shibani Bhandari, Vineet Huang, Weimin Pan, Xinnian Zhou, Wenhao |
author_facet | Yan, Kai Cheng, Guoqiang Zhou, Wei Xiao, Feifan Zhang, Chongfan Wang, Laishuan Zhang, Peng Lu, Chunmei Kong, Yanting Wang, Xinhua Zhou, Yuanfeng Lu, Weineng Tang, Juan Song, Xiaoyan Wei, Qiufen Meng, Danhua Yao, Liping Zhuang, Deyi Qu, Liuhong Xu, Qinghuo Yin, Zhaoqing Su, Le Wan, Jing Si, Yuan Fujioka, Kazumichi Mussap, Michele Kanungo, Shibani Bhandari, Vineet Huang, Weimin Pan, Xinnian Zhou, Wenhao |
author_sort | Yan, Kai |
collection | PubMed |
description | IMPORTANCE: Neonatal seizures pose a significant challenge in critical care, and continuous video electroencephalography (cEEG) monitoring holds promise for early detection of seizures. However, large-scale data on the incidence of neonatal seizures and monitoring systems in China are lacking. OBJECTIVES: To determine the incidence of neonatal seizures in infants with high risk in China. DESIGN, SETTING, AND PARTICIPANTS: A large, cross-sectional multicenter study was conducted from January 2017 to December 2018 in the neonatal intensive care units (NICUs) of 7 tertiary medical centers in China. Neonates with high risk were included, and cEEG monitoring was conducted. Data were collected between January 1, 2017, and January 31, 2020. The data were analyzed between January 2021 and January 2022. MAIN OUTCOMES AND MEASURES: The incidence of neonatal seizures, categorized by etiology, and seizure burden. RESULTS: A total of 20 310 neonates with high risk were included (10 495 [51.7%] male; mean [SD] postmenstrual age, 37.7 [3.7] weeks), and seizures were observed in 3423 infants (16.9%). The highest proportion of seizures was attributed to acute neonatal encephalopathy (1448 [42.3%]). The incidence of seizures decreased with postmenstrual age and birth weight, with the highest occurrence observed in neonates with postmenstrual age of less than 28 weeks (237 of 879 [27.0%]) or birth weight of less than 1.0 kg (269 of 914 [29.4%]). Preterm infants had a higher proportion of moderate and severe seizure burdens compared with full-term infants (moderate severity: 248 of 1199 [20.7%] vs 454 of 2224 [20.4%]), but no significant differences were observed in etiology. Seizure burden was highest with genetic syndromes (49 of 188 [26.1%]), central nervous system malformations (33 of 127 [26.0%]), and inborn errors of metabolism (27 of 113 [23.9%]). During hospitalization, 7.8% of neonates with seizures died (267 neonates), with 81.3% of these cases having a moderate or severe seizure burden (217 neonates). Mortality was generally higher in preterm vs full-term infants (98 of 1199 [8.2%] vs 169 of 2224 [7.6%]) and increased with the severity of seizure burden (217 of 267 neonates with moderate or severe burden [81.3%]). CONCLUSIONS AND RELEVANCE: This cross-sectional study of neonatal seizures underscores the substantial burden seizures pose to high-risk infants with brain injury in China, particularly those who are born prematurely or who have congenital conditions. |
format | Online Article Text |
id | pubmed-10383014 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | American Medical Association |
record_format | MEDLINE/PubMed |
spelling | pubmed-103830142023-07-30 Incidence of Neonatal Seizures in China Based on Electroencephalogram Monitoring in Neonatal Neurocritical Care Units Yan, Kai Cheng, Guoqiang Zhou, Wei Xiao, Feifan Zhang, Chongfan Wang, Laishuan Zhang, Peng Lu, Chunmei Kong, Yanting Wang, Xinhua Zhou, Yuanfeng Lu, Weineng Tang, Juan Song, Xiaoyan Wei, Qiufen Meng, Danhua Yao, Liping Zhuang, Deyi Qu, Liuhong Xu, Qinghuo Yin, Zhaoqing Su, Le Wan, Jing Si, Yuan Fujioka, Kazumichi Mussap, Michele Kanungo, Shibani Bhandari, Vineet Huang, Weimin Pan, Xinnian Zhou, Wenhao JAMA Netw Open Original Investigation IMPORTANCE: Neonatal seizures pose a significant challenge in critical care, and continuous video electroencephalography (cEEG) monitoring holds promise for early detection of seizures. However, large-scale data on the incidence of neonatal seizures and monitoring systems in China are lacking. OBJECTIVES: To determine the incidence of neonatal seizures in infants with high risk in China. DESIGN, SETTING, AND PARTICIPANTS: A large, cross-sectional multicenter study was conducted from January 2017 to December 2018 in the neonatal intensive care units (NICUs) of 7 tertiary medical centers in China. Neonates with high risk were included, and cEEG monitoring was conducted. Data were collected between January 1, 2017, and January 31, 2020. The data were analyzed between January 2021 and January 2022. MAIN OUTCOMES AND MEASURES: The incidence of neonatal seizures, categorized by etiology, and seizure burden. RESULTS: A total of 20 310 neonates with high risk were included (10 495 [51.7%] male; mean [SD] postmenstrual age, 37.7 [3.7] weeks), and seizures were observed in 3423 infants (16.9%). The highest proportion of seizures was attributed to acute neonatal encephalopathy (1448 [42.3%]). The incidence of seizures decreased with postmenstrual age and birth weight, with the highest occurrence observed in neonates with postmenstrual age of less than 28 weeks (237 of 879 [27.0%]) or birth weight of less than 1.0 kg (269 of 914 [29.4%]). Preterm infants had a higher proportion of moderate and severe seizure burdens compared with full-term infants (moderate severity: 248 of 1199 [20.7%] vs 454 of 2224 [20.4%]), but no significant differences were observed in etiology. Seizure burden was highest with genetic syndromes (49 of 188 [26.1%]), central nervous system malformations (33 of 127 [26.0%]), and inborn errors of metabolism (27 of 113 [23.9%]). During hospitalization, 7.8% of neonates with seizures died (267 neonates), with 81.3% of these cases having a moderate or severe seizure burden (217 neonates). Mortality was generally higher in preterm vs full-term infants (98 of 1199 [8.2%] vs 169 of 2224 [7.6%]) and increased with the severity of seizure burden (217 of 267 neonates with moderate or severe burden [81.3%]). CONCLUSIONS AND RELEVANCE: This cross-sectional study of neonatal seizures underscores the substantial burden seizures pose to high-risk infants with brain injury in China, particularly those who are born prematurely or who have congenital conditions. American Medical Association 2023-07-28 /pmc/articles/PMC10383014/ /pubmed/37505497 http://dx.doi.org/10.1001/jamanetworkopen.2023.26301 Text en Copyright 2023 Yan K et al. JAMA Network Open. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the CC-BY License. |
spellingShingle | Original Investigation Yan, Kai Cheng, Guoqiang Zhou, Wei Xiao, Feifan Zhang, Chongfan Wang, Laishuan Zhang, Peng Lu, Chunmei Kong, Yanting Wang, Xinhua Zhou, Yuanfeng Lu, Weineng Tang, Juan Song, Xiaoyan Wei, Qiufen Meng, Danhua Yao, Liping Zhuang, Deyi Qu, Liuhong Xu, Qinghuo Yin, Zhaoqing Su, Le Wan, Jing Si, Yuan Fujioka, Kazumichi Mussap, Michele Kanungo, Shibani Bhandari, Vineet Huang, Weimin Pan, Xinnian Zhou, Wenhao Incidence of Neonatal Seizures in China Based on Electroencephalogram Monitoring in Neonatal Neurocritical Care Units |
title | Incidence of Neonatal Seizures in China Based on Electroencephalogram Monitoring in Neonatal Neurocritical Care Units |
title_full | Incidence of Neonatal Seizures in China Based on Electroencephalogram Monitoring in Neonatal Neurocritical Care Units |
title_fullStr | Incidence of Neonatal Seizures in China Based on Electroencephalogram Monitoring in Neonatal Neurocritical Care Units |
title_full_unstemmed | Incidence of Neonatal Seizures in China Based on Electroencephalogram Monitoring in Neonatal Neurocritical Care Units |
title_short | Incidence of Neonatal Seizures in China Based on Electroencephalogram Monitoring in Neonatal Neurocritical Care Units |
title_sort | incidence of neonatal seizures in china based on electroencephalogram monitoring in neonatal neurocritical care units |
topic | Original Investigation |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10383014/ https://www.ncbi.nlm.nih.gov/pubmed/37505497 http://dx.doi.org/10.1001/jamanetworkopen.2023.26301 |
work_keys_str_mv | AT yankai incidenceofneonatalseizuresinchinabasedonelectroencephalogrammonitoringinneonatalneurocriticalcareunits AT chengguoqiang incidenceofneonatalseizuresinchinabasedonelectroencephalogrammonitoringinneonatalneurocriticalcareunits AT zhouwei incidenceofneonatalseizuresinchinabasedonelectroencephalogrammonitoringinneonatalneurocriticalcareunits AT xiaofeifan incidenceofneonatalseizuresinchinabasedonelectroencephalogrammonitoringinneonatalneurocriticalcareunits AT zhangchongfan incidenceofneonatalseizuresinchinabasedonelectroencephalogrammonitoringinneonatalneurocriticalcareunits AT wanglaishuan incidenceofneonatalseizuresinchinabasedonelectroencephalogrammonitoringinneonatalneurocriticalcareunits AT zhangpeng incidenceofneonatalseizuresinchinabasedonelectroencephalogrammonitoringinneonatalneurocriticalcareunits AT luchunmei incidenceofneonatalseizuresinchinabasedonelectroencephalogrammonitoringinneonatalneurocriticalcareunits AT kongyanting incidenceofneonatalseizuresinchinabasedonelectroencephalogrammonitoringinneonatalneurocriticalcareunits AT wangxinhua incidenceofneonatalseizuresinchinabasedonelectroencephalogrammonitoringinneonatalneurocriticalcareunits AT zhouyuanfeng incidenceofneonatalseizuresinchinabasedonelectroencephalogrammonitoringinneonatalneurocriticalcareunits AT luweineng incidenceofneonatalseizuresinchinabasedonelectroencephalogrammonitoringinneonatalneurocriticalcareunits AT tangjuan incidenceofneonatalseizuresinchinabasedonelectroencephalogrammonitoringinneonatalneurocriticalcareunits AT songxiaoyan incidenceofneonatalseizuresinchinabasedonelectroencephalogrammonitoringinneonatalneurocriticalcareunits AT weiqiufen incidenceofneonatalseizuresinchinabasedonelectroencephalogrammonitoringinneonatalneurocriticalcareunits AT mengdanhua incidenceofneonatalseizuresinchinabasedonelectroencephalogrammonitoringinneonatalneurocriticalcareunits AT yaoliping incidenceofneonatalseizuresinchinabasedonelectroencephalogrammonitoringinneonatalneurocriticalcareunits AT zhuangdeyi incidenceofneonatalseizuresinchinabasedonelectroencephalogrammonitoringinneonatalneurocriticalcareunits AT quliuhong incidenceofneonatalseizuresinchinabasedonelectroencephalogrammonitoringinneonatalneurocriticalcareunits AT xuqinghuo incidenceofneonatalseizuresinchinabasedonelectroencephalogrammonitoringinneonatalneurocriticalcareunits AT yinzhaoqing incidenceofneonatalseizuresinchinabasedonelectroencephalogrammonitoringinneonatalneurocriticalcareunits AT sule incidenceofneonatalseizuresinchinabasedonelectroencephalogrammonitoringinneonatalneurocriticalcareunits AT wanjing incidenceofneonatalseizuresinchinabasedonelectroencephalogrammonitoringinneonatalneurocriticalcareunits AT siyuan incidenceofneonatalseizuresinchinabasedonelectroencephalogrammonitoringinneonatalneurocriticalcareunits AT fujiokakazumichi incidenceofneonatalseizuresinchinabasedonelectroencephalogrammonitoringinneonatalneurocriticalcareunits AT mussapmichele incidenceofneonatalseizuresinchinabasedonelectroencephalogrammonitoringinneonatalneurocriticalcareunits AT kanungoshibani incidenceofneonatalseizuresinchinabasedonelectroencephalogrammonitoringinneonatalneurocriticalcareunits AT bhandarivineet incidenceofneonatalseizuresinchinabasedonelectroencephalogrammonitoringinneonatalneurocriticalcareunits AT huangweimin incidenceofneonatalseizuresinchinabasedonelectroencephalogrammonitoringinneonatalneurocriticalcareunits AT panxinnian incidenceofneonatalseizuresinchinabasedonelectroencephalogrammonitoringinneonatalneurocriticalcareunits AT zhouwenhao incidenceofneonatalseizuresinchinabasedonelectroencephalogrammonitoringinneonatalneurocriticalcareunits |