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EHO-85, Novel Amorphous Antioxidant Hydrogel, Containing Olea europaea Leaf Extract—Rheological Properties, and Superiority over a Standard Hydrogel in Accelerating Early Wound Healing: A Randomized Controlled Trial
Many advanced wound healing dressings exist, but there is little high-quality evidence to support them. To determine the performance of a novel amorphous hydrogel (EHO-85) in relation to its application, we compared its rheological properties with those of other standard hydrogels (SH), and we asses...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10383111/ https://www.ncbi.nlm.nih.gov/pubmed/37514112 http://dx.doi.org/10.3390/pharmaceutics15071925 |
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author | Verdú-Soriano, José de Cristino-Espinar, Marisol Luna-Morales, Silvia Dios-Guerra, Caridad Casado-Díaz, Antonio Quesada-Gómez, José Manuel Dorado, Gabriel Berenguer-Pérez, Miriam Vílchez, Susana Esquena, Jordi Rodríguez-Mañas, Leocadio Lázaro-Martínez, José Luis |
author_facet | Verdú-Soriano, José de Cristino-Espinar, Marisol Luna-Morales, Silvia Dios-Guerra, Caridad Casado-Díaz, Antonio Quesada-Gómez, José Manuel Dorado, Gabriel Berenguer-Pérez, Miriam Vílchez, Susana Esquena, Jordi Rodríguez-Mañas, Leocadio Lázaro-Martínez, José Luis |
author_sort | Verdú-Soriano, José |
collection | PubMed |
description | Many advanced wound healing dressings exist, but there is little high-quality evidence to support them. To determine the performance of a novel amorphous hydrogel (EHO-85) in relation to its application, we compared its rheological properties with those of other standard hydrogels (SH), and we assessed the induction of acceleration of the early stages of wound healing as a secondary objective of a prospective, multicenter, randomized, observer-blinded, controlled trial. The patients were recruited if they had pressure, venous, or diabetic foot ulcers and were treated with EHO-85 (n = 103) or VariHesive(®) (SH) (n = 92), and their response was assessed by intention-to-treat as wound area reduction (WAR (%)) and healing rate (HR mm(2)/day) in the second and fourth weeks of treatment. Results: EHO-85 had the highest shear thinning and G′/G″ ratio, the lowest viscous modulus, G″, and relatively low cohesive energy; EHO-85 had a significantly superior effect over SH in WAR and HR, accelerating wound healing in the second and fourth weeks of application (p: 0.002). This superiority is likely based on its optimal moisturizing capacity and excellent pH-lowering and antioxidant properties. In addition, the distinct shear thinning of EHO-85 facilitates spreading by gentle hand pressure, making it easier to apply to wounds. These rheological properties contribute to its improved performance. |
format | Online Article Text |
id | pubmed-10383111 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-103831112023-07-30 EHO-85, Novel Amorphous Antioxidant Hydrogel, Containing Olea europaea Leaf Extract—Rheological Properties, and Superiority over a Standard Hydrogel in Accelerating Early Wound Healing: A Randomized Controlled Trial Verdú-Soriano, José de Cristino-Espinar, Marisol Luna-Morales, Silvia Dios-Guerra, Caridad Casado-Díaz, Antonio Quesada-Gómez, José Manuel Dorado, Gabriel Berenguer-Pérez, Miriam Vílchez, Susana Esquena, Jordi Rodríguez-Mañas, Leocadio Lázaro-Martínez, José Luis Pharmaceutics Article Many advanced wound healing dressings exist, but there is little high-quality evidence to support them. To determine the performance of a novel amorphous hydrogel (EHO-85) in relation to its application, we compared its rheological properties with those of other standard hydrogels (SH), and we assessed the induction of acceleration of the early stages of wound healing as a secondary objective of a prospective, multicenter, randomized, observer-blinded, controlled trial. The patients were recruited if they had pressure, venous, or diabetic foot ulcers and were treated with EHO-85 (n = 103) or VariHesive(®) (SH) (n = 92), and their response was assessed by intention-to-treat as wound area reduction (WAR (%)) and healing rate (HR mm(2)/day) in the second and fourth weeks of treatment. Results: EHO-85 had the highest shear thinning and G′/G″ ratio, the lowest viscous modulus, G″, and relatively low cohesive energy; EHO-85 had a significantly superior effect over SH in WAR and HR, accelerating wound healing in the second and fourth weeks of application (p: 0.002). This superiority is likely based on its optimal moisturizing capacity and excellent pH-lowering and antioxidant properties. In addition, the distinct shear thinning of EHO-85 facilitates spreading by gentle hand pressure, making it easier to apply to wounds. These rheological properties contribute to its improved performance. MDPI 2023-07-11 /pmc/articles/PMC10383111/ /pubmed/37514112 http://dx.doi.org/10.3390/pharmaceutics15071925 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Verdú-Soriano, José de Cristino-Espinar, Marisol Luna-Morales, Silvia Dios-Guerra, Caridad Casado-Díaz, Antonio Quesada-Gómez, José Manuel Dorado, Gabriel Berenguer-Pérez, Miriam Vílchez, Susana Esquena, Jordi Rodríguez-Mañas, Leocadio Lázaro-Martínez, José Luis EHO-85, Novel Amorphous Antioxidant Hydrogel, Containing Olea europaea Leaf Extract—Rheological Properties, and Superiority over a Standard Hydrogel in Accelerating Early Wound Healing: A Randomized Controlled Trial |
title | EHO-85, Novel Amorphous Antioxidant Hydrogel, Containing Olea europaea Leaf Extract—Rheological Properties, and Superiority over a Standard Hydrogel in Accelerating Early Wound Healing: A Randomized Controlled Trial |
title_full | EHO-85, Novel Amorphous Antioxidant Hydrogel, Containing Olea europaea Leaf Extract—Rheological Properties, and Superiority over a Standard Hydrogel in Accelerating Early Wound Healing: A Randomized Controlled Trial |
title_fullStr | EHO-85, Novel Amorphous Antioxidant Hydrogel, Containing Olea europaea Leaf Extract—Rheological Properties, and Superiority over a Standard Hydrogel in Accelerating Early Wound Healing: A Randomized Controlled Trial |
title_full_unstemmed | EHO-85, Novel Amorphous Antioxidant Hydrogel, Containing Olea europaea Leaf Extract—Rheological Properties, and Superiority over a Standard Hydrogel in Accelerating Early Wound Healing: A Randomized Controlled Trial |
title_short | EHO-85, Novel Amorphous Antioxidant Hydrogel, Containing Olea europaea Leaf Extract—Rheological Properties, and Superiority over a Standard Hydrogel in Accelerating Early Wound Healing: A Randomized Controlled Trial |
title_sort | eho-85, novel amorphous antioxidant hydrogel, containing olea europaea leaf extract—rheological properties, and superiority over a standard hydrogel in accelerating early wound healing: a randomized controlled trial |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10383111/ https://www.ncbi.nlm.nih.gov/pubmed/37514112 http://dx.doi.org/10.3390/pharmaceutics15071925 |
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