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Microbial Growth under Limiting Conditions-Future Perspectives

Microorganisms rule the functioning of our planet and each one of the individual macroscopic living creature. Nevertheless, microbial activity and growth status have always been challenging tasks to determine both in situ and in vivo. Microbial activity is generally related to growth, and the growth...

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Detalles Bibliográficos
Autores principales: Gonzalez, Juan M., Aranda, Beatriz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10383181/
https://www.ncbi.nlm.nih.gov/pubmed/37512814
http://dx.doi.org/10.3390/microorganisms11071641
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author Gonzalez, Juan M.
Aranda, Beatriz
author_facet Gonzalez, Juan M.
Aranda, Beatriz
author_sort Gonzalez, Juan M.
collection PubMed
description Microorganisms rule the functioning of our planet and each one of the individual macroscopic living creature. Nevertheless, microbial activity and growth status have always been challenging tasks to determine both in situ and in vivo. Microbial activity is generally related to growth, and the growth rate is a result of the availability of nutrients under adequate or adverse conditions faced by microbial cells in a changing environment. Most studies on microorganisms have been carried out under optimum or near-optimum growth conditions, but scarce information is available about microorganisms at slow-growing states (i.e., near-zero growth and maintenance metabolism). This study aims to better understand microorganisms under growth-limiting conditions. This is expected to provide new perspectives on the functions and relevance of the microbial world. This is because (i) microorganisms in nature frequently face conditions of severe growth limitation, (ii) microorganisms activate singular pathways (mostly genes remaining to be functionally annotated), resulting in a broad range of secondary metabolites, and (iii) the response of microorganisms to slow-growth conditions remains to be understood, including persistence strategies, gene expression, and cell differentiation both within clonal populations and due to the complexity of the environment.
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spelling pubmed-103831812023-07-30 Microbial Growth under Limiting Conditions-Future Perspectives Gonzalez, Juan M. Aranda, Beatriz Microorganisms Review Microorganisms rule the functioning of our planet and each one of the individual macroscopic living creature. Nevertheless, microbial activity and growth status have always been challenging tasks to determine both in situ and in vivo. Microbial activity is generally related to growth, and the growth rate is a result of the availability of nutrients under adequate or adverse conditions faced by microbial cells in a changing environment. Most studies on microorganisms have been carried out under optimum or near-optimum growth conditions, but scarce information is available about microorganisms at slow-growing states (i.e., near-zero growth and maintenance metabolism). This study aims to better understand microorganisms under growth-limiting conditions. This is expected to provide new perspectives on the functions and relevance of the microbial world. This is because (i) microorganisms in nature frequently face conditions of severe growth limitation, (ii) microorganisms activate singular pathways (mostly genes remaining to be functionally annotated), resulting in a broad range of secondary metabolites, and (iii) the response of microorganisms to slow-growth conditions remains to be understood, including persistence strategies, gene expression, and cell differentiation both within clonal populations and due to the complexity of the environment. MDPI 2023-06-23 /pmc/articles/PMC10383181/ /pubmed/37512814 http://dx.doi.org/10.3390/microorganisms11071641 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Gonzalez, Juan M.
Aranda, Beatriz
Microbial Growth under Limiting Conditions-Future Perspectives
title Microbial Growth under Limiting Conditions-Future Perspectives
title_full Microbial Growth under Limiting Conditions-Future Perspectives
title_fullStr Microbial Growth under Limiting Conditions-Future Perspectives
title_full_unstemmed Microbial Growth under Limiting Conditions-Future Perspectives
title_short Microbial Growth under Limiting Conditions-Future Perspectives
title_sort microbial growth under limiting conditions-future perspectives
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10383181/
https://www.ncbi.nlm.nih.gov/pubmed/37512814
http://dx.doi.org/10.3390/microorganisms11071641
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