Cargando…
Comparison of Postoperative Nausea and Vomiting Incidence between Remimazolam and Sevoflurane in Tympanoplasty with Mastoidectomy: A Single-Center, Double-Blind, Randomized Controlled Trial
Background and Objectives: Postoperative nausea and vomiting (PONV) is a common adverse effect of general anesthesia, especially in middle ear surgery. Remimazolam is a newer benzodiazepine recently approved for use in general anesthesia. This study aimed to compare the incidence rate of PONV after...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10383232/ https://www.ncbi.nlm.nih.gov/pubmed/37512009 http://dx.doi.org/10.3390/medicina59071197 |
_version_ | 1785080857760890880 |
---|---|
author | Lee, Seung Cheol Jung, Ji Wook Choi, So Ron Chung, Chan Jong Lee, Tae Young Park, Sang Yoong |
author_facet | Lee, Seung Cheol Jung, Ji Wook Choi, So Ron Chung, Chan Jong Lee, Tae Young Park, Sang Yoong |
author_sort | Lee, Seung Cheol |
collection | PubMed |
description | Background and Objectives: Postoperative nausea and vomiting (PONV) is a common adverse effect of general anesthesia, especially in middle ear surgery. Remimazolam is a newer benzodiazepine recently approved for use in general anesthesia. This study aimed to compare the incidence rate of PONV after tympanoplasty with mastoidectomy between using remimazolam and sevoflurane. Materials and Methods: This study included 80 patients undergoing elective tympanoplasty with mastoidectomy. The patients were randomly assigned to either the remimazolam or sevoflurane group. The primary outcome was the incidence rate of PONV 12 h after surgery. The secondary outcomes were the incidence rate of PONV 12–24 and 24–48 h after surgery, severity of PONV, incidence rate of vomiting, administration of rescue antiemetics, hemodynamic stability, and recovery profiles. Results: The incidence rate of PONV 0–12 h after tympanoplasty with mastoidectomy was significantly lower in the remimazolam group compared with that in the sevoflurane group (28.9 vs. 57.9%; p = 0.011). However, the incidence rate of delayed PONV did not differ between the two groups. PONV severity in the early periods after the surgery was significantly lower in the remimazolam group than in the sevoflurane group. The incidence rate of adverse hemodynamic events was lower in the remimazolam group than in the sevoflurane group, but there was no difference in the overall trends of hemodynamic data between the two groups. There was no difference in recovery profiles between the two groups. Conclusions: Remimazolam can significantly reduce the incidence rate of early PONV after tympanoplasty with mastoidectomy under general anesthesia. |
format | Online Article Text |
id | pubmed-10383232 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-103832322023-07-30 Comparison of Postoperative Nausea and Vomiting Incidence between Remimazolam and Sevoflurane in Tympanoplasty with Mastoidectomy: A Single-Center, Double-Blind, Randomized Controlled Trial Lee, Seung Cheol Jung, Ji Wook Choi, So Ron Chung, Chan Jong Lee, Tae Young Park, Sang Yoong Medicina (Kaunas) Article Background and Objectives: Postoperative nausea and vomiting (PONV) is a common adverse effect of general anesthesia, especially in middle ear surgery. Remimazolam is a newer benzodiazepine recently approved for use in general anesthesia. This study aimed to compare the incidence rate of PONV after tympanoplasty with mastoidectomy between using remimazolam and sevoflurane. Materials and Methods: This study included 80 patients undergoing elective tympanoplasty with mastoidectomy. The patients were randomly assigned to either the remimazolam or sevoflurane group. The primary outcome was the incidence rate of PONV 12 h after surgery. The secondary outcomes were the incidence rate of PONV 12–24 and 24–48 h after surgery, severity of PONV, incidence rate of vomiting, administration of rescue antiemetics, hemodynamic stability, and recovery profiles. Results: The incidence rate of PONV 0–12 h after tympanoplasty with mastoidectomy was significantly lower in the remimazolam group compared with that in the sevoflurane group (28.9 vs. 57.9%; p = 0.011). However, the incidence rate of delayed PONV did not differ between the two groups. PONV severity in the early periods after the surgery was significantly lower in the remimazolam group than in the sevoflurane group. The incidence rate of adverse hemodynamic events was lower in the remimazolam group than in the sevoflurane group, but there was no difference in the overall trends of hemodynamic data between the two groups. There was no difference in recovery profiles between the two groups. Conclusions: Remimazolam can significantly reduce the incidence rate of early PONV after tympanoplasty with mastoidectomy under general anesthesia. MDPI 2023-06-25 /pmc/articles/PMC10383232/ /pubmed/37512009 http://dx.doi.org/10.3390/medicina59071197 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Lee, Seung Cheol Jung, Ji Wook Choi, So Ron Chung, Chan Jong Lee, Tae Young Park, Sang Yoong Comparison of Postoperative Nausea and Vomiting Incidence between Remimazolam and Sevoflurane in Tympanoplasty with Mastoidectomy: A Single-Center, Double-Blind, Randomized Controlled Trial |
title | Comparison of Postoperative Nausea and Vomiting Incidence between Remimazolam and Sevoflurane in Tympanoplasty with Mastoidectomy: A Single-Center, Double-Blind, Randomized Controlled Trial |
title_full | Comparison of Postoperative Nausea and Vomiting Incidence between Remimazolam and Sevoflurane in Tympanoplasty with Mastoidectomy: A Single-Center, Double-Blind, Randomized Controlled Trial |
title_fullStr | Comparison of Postoperative Nausea and Vomiting Incidence between Remimazolam and Sevoflurane in Tympanoplasty with Mastoidectomy: A Single-Center, Double-Blind, Randomized Controlled Trial |
title_full_unstemmed | Comparison of Postoperative Nausea and Vomiting Incidence between Remimazolam and Sevoflurane in Tympanoplasty with Mastoidectomy: A Single-Center, Double-Blind, Randomized Controlled Trial |
title_short | Comparison of Postoperative Nausea and Vomiting Incidence between Remimazolam and Sevoflurane in Tympanoplasty with Mastoidectomy: A Single-Center, Double-Blind, Randomized Controlled Trial |
title_sort | comparison of postoperative nausea and vomiting incidence between remimazolam and sevoflurane in tympanoplasty with mastoidectomy: a single-center, double-blind, randomized controlled trial |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10383232/ https://www.ncbi.nlm.nih.gov/pubmed/37512009 http://dx.doi.org/10.3390/medicina59071197 |
work_keys_str_mv | AT leeseungcheol comparisonofpostoperativenauseaandvomitingincidencebetweenremimazolamandsevofluraneintympanoplastywithmastoidectomyasinglecenterdoubleblindrandomizedcontrolledtrial AT jungjiwook comparisonofpostoperativenauseaandvomitingincidencebetweenremimazolamandsevofluraneintympanoplastywithmastoidectomyasinglecenterdoubleblindrandomizedcontrolledtrial AT choisoron comparisonofpostoperativenauseaandvomitingincidencebetweenremimazolamandsevofluraneintympanoplastywithmastoidectomyasinglecenterdoubleblindrandomizedcontrolledtrial AT chungchanjong comparisonofpostoperativenauseaandvomitingincidencebetweenremimazolamandsevofluraneintympanoplastywithmastoidectomyasinglecenterdoubleblindrandomizedcontrolledtrial AT leetaeyoung comparisonofpostoperativenauseaandvomitingincidencebetweenremimazolamandsevofluraneintympanoplastywithmastoidectomyasinglecenterdoubleblindrandomizedcontrolledtrial AT parksangyoong comparisonofpostoperativenauseaandvomitingincidencebetweenremimazolamandsevofluraneintympanoplastywithmastoidectomyasinglecenterdoubleblindrandomizedcontrolledtrial |