Hepatitis Delta Virus–Host Protein Interactions: From Entry to Egress

Hepatitis delta virus (HDV) is the smallest known human virus and causes the most severe form of human viral hepatitis, yet it is still not fully understood how the virus replicates and how it interacts with many host proteins during replication. This review aims to provide a systematic review of al...

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Detalles Bibliográficos
Autores principales: Stephenson-Tsoris, Susannah, Liang, T. Jake
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10383234/
https://www.ncbi.nlm.nih.gov/pubmed/37515216
http://dx.doi.org/10.3390/v15071530
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author Stephenson-Tsoris, Susannah
Liang, T. Jake
author_facet Stephenson-Tsoris, Susannah
Liang, T. Jake
author_sort Stephenson-Tsoris, Susannah
collection PubMed
description Hepatitis delta virus (HDV) is the smallest known human virus and causes the most severe form of human viral hepatitis, yet it is still not fully understood how the virus replicates and how it interacts with many host proteins during replication. This review aims to provide a systematic review of all the host factors currently known to interact with HDV and their mechanistic involvement in all steps of the HDV replication cycle. Finally, we discuss implications for therapeutic development based on our current knowledge of HDV–host protein interactions.
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spelling pubmed-103832342023-07-30 Hepatitis Delta Virus–Host Protein Interactions: From Entry to Egress Stephenson-Tsoris, Susannah Liang, T. Jake Viruses Review Hepatitis delta virus (HDV) is the smallest known human virus and causes the most severe form of human viral hepatitis, yet it is still not fully understood how the virus replicates and how it interacts with many host proteins during replication. This review aims to provide a systematic review of all the host factors currently known to interact with HDV and their mechanistic involvement in all steps of the HDV replication cycle. Finally, we discuss implications for therapeutic development based on our current knowledge of HDV–host protein interactions. MDPI 2023-07-11 /pmc/articles/PMC10383234/ /pubmed/37515216 http://dx.doi.org/10.3390/v15071530 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Stephenson-Tsoris, Susannah
Liang, T. Jake
Hepatitis Delta Virus–Host Protein Interactions: From Entry to Egress
title Hepatitis Delta Virus–Host Protein Interactions: From Entry to Egress
title_full Hepatitis Delta Virus–Host Protein Interactions: From Entry to Egress
title_fullStr Hepatitis Delta Virus–Host Protein Interactions: From Entry to Egress
title_full_unstemmed Hepatitis Delta Virus–Host Protein Interactions: From Entry to Egress
title_short Hepatitis Delta Virus–Host Protein Interactions: From Entry to Egress
title_sort hepatitis delta virus–host protein interactions: from entry to egress
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10383234/
https://www.ncbi.nlm.nih.gov/pubmed/37515216
http://dx.doi.org/10.3390/v15071530
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