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Polymer-Based Hydrogel Loaded with Honey in Drug Delivery System for Wound Healing Applications
Excellent wound dressings should have crucial components, including high porosity, non-toxicity, high water absorption, and the ability to retain a humid environment in the wound area and facilitate wound healing. Unfortunately, current wound dressings hamper the healing process, with poor antibacte...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10383286/ https://www.ncbi.nlm.nih.gov/pubmed/37514474 http://dx.doi.org/10.3390/polym15143085 |
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author | Yasin, Siti Nor Najihah Said, Zulfahmi Halib, Nadia Rahman, Zulaiha A Mokhzani, Noor Izzati |
author_facet | Yasin, Siti Nor Najihah Said, Zulfahmi Halib, Nadia Rahman, Zulaiha A Mokhzani, Noor Izzati |
author_sort | Yasin, Siti Nor Najihah |
collection | PubMed |
description | Excellent wound dressings should have crucial components, including high porosity, non-toxicity, high water absorption, and the ability to retain a humid environment in the wound area and facilitate wound healing. Unfortunately, current wound dressings hamper the healing process, with poor antibacterial, anti-inflammatory, and antioxidant activity, frequent dressing changes, low biodegradability, and poor mechanical properties. Hydrogels are crosslinked polymer chains with three-dimensional (3D) networks that have been applicable as wound dressings. They could retain a humid environment on the wound site, provide a protective barrier against pathogenic infections, and provide pain relief. Hydrogel can be obtained from natural, synthetic, or hybrid polymers. Honey is a natural substance that has demonstrated several therapeutic efficacies, including anti-inflammatory, antibacterial, and antioxidant activity, which makes it beneficial for wound treatment. Honey-based hydrogel wound dressings demonstrated excellent characteristics, including good biodegradability and biocompatibility, stimulated cell proliferation and reepithelization, inhibited bacterial growth, and accelerated wound healing. This review aimed to demonstrate the potential of honey-based hydrogel in wound healing applications and complement the studies accessible regarding implementing honey-based hydrogel dressing for wound healing. |
format | Online Article Text |
id | pubmed-10383286 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-103832862023-07-30 Polymer-Based Hydrogel Loaded with Honey in Drug Delivery System for Wound Healing Applications Yasin, Siti Nor Najihah Said, Zulfahmi Halib, Nadia Rahman, Zulaiha A Mokhzani, Noor Izzati Polymers (Basel) Review Excellent wound dressings should have crucial components, including high porosity, non-toxicity, high water absorption, and the ability to retain a humid environment in the wound area and facilitate wound healing. Unfortunately, current wound dressings hamper the healing process, with poor antibacterial, anti-inflammatory, and antioxidant activity, frequent dressing changes, low biodegradability, and poor mechanical properties. Hydrogels are crosslinked polymer chains with three-dimensional (3D) networks that have been applicable as wound dressings. They could retain a humid environment on the wound site, provide a protective barrier against pathogenic infections, and provide pain relief. Hydrogel can be obtained from natural, synthetic, or hybrid polymers. Honey is a natural substance that has demonstrated several therapeutic efficacies, including anti-inflammatory, antibacterial, and antioxidant activity, which makes it beneficial for wound treatment. Honey-based hydrogel wound dressings demonstrated excellent characteristics, including good biodegradability and biocompatibility, stimulated cell proliferation and reepithelization, inhibited bacterial growth, and accelerated wound healing. This review aimed to demonstrate the potential of honey-based hydrogel in wound healing applications and complement the studies accessible regarding implementing honey-based hydrogel dressing for wound healing. MDPI 2023-07-18 /pmc/articles/PMC10383286/ /pubmed/37514474 http://dx.doi.org/10.3390/polym15143085 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Yasin, Siti Nor Najihah Said, Zulfahmi Halib, Nadia Rahman, Zulaiha A Mokhzani, Noor Izzati Polymer-Based Hydrogel Loaded with Honey in Drug Delivery System for Wound Healing Applications |
title | Polymer-Based Hydrogel Loaded with Honey in Drug Delivery System for Wound Healing Applications |
title_full | Polymer-Based Hydrogel Loaded with Honey in Drug Delivery System for Wound Healing Applications |
title_fullStr | Polymer-Based Hydrogel Loaded with Honey in Drug Delivery System for Wound Healing Applications |
title_full_unstemmed | Polymer-Based Hydrogel Loaded with Honey in Drug Delivery System for Wound Healing Applications |
title_short | Polymer-Based Hydrogel Loaded with Honey in Drug Delivery System for Wound Healing Applications |
title_sort | polymer-based hydrogel loaded with honey in drug delivery system for wound healing applications |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10383286/ https://www.ncbi.nlm.nih.gov/pubmed/37514474 http://dx.doi.org/10.3390/polym15143085 |
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