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Characterization and Short-Term Outcome of Potential Celiac Disease in Children

Background and Objectives: Potential Celiac Disease (PCD) is defined by positive celiac serology without villous atrophy. We aimed to describe the short-term outcome of pediatric PCD while consuming a gluten-containing diet (GCD). Materials and Methods: Retrospective analysis of pediatric PCD patien...

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Autores principales: Kori, Michal, Topf-Olivestone, Chani, Rinawi, Firas, Lev-Tzion, Raffi, Ziv-Sokolovskaya, Nadya, Lapidot Alon, Noy, Guz-Mark, Anat, Shamir, Raanan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10383287/
https://www.ncbi.nlm.nih.gov/pubmed/37511994
http://dx.doi.org/10.3390/medicina59071182
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author Kori, Michal
Topf-Olivestone, Chani
Rinawi, Firas
Lev-Tzion, Raffi
Ziv-Sokolovskaya, Nadya
Lapidot Alon, Noy
Guz-Mark, Anat
Shamir, Raanan
author_facet Kori, Michal
Topf-Olivestone, Chani
Rinawi, Firas
Lev-Tzion, Raffi
Ziv-Sokolovskaya, Nadya
Lapidot Alon, Noy
Guz-Mark, Anat
Shamir, Raanan
author_sort Kori, Michal
collection PubMed
description Background and Objectives: Potential Celiac Disease (PCD) is defined by positive celiac serology without villous atrophy. We aimed to describe the short-term outcome of pediatric PCD while consuming a gluten-containing diet (GCD). Materials and Methods: Retrospective analysis of pediatric PCD patients continuing GCD, between December 2018–January 2022. Baseline demographics, celiac serology and duodenal biopsy results were reviewed. Follow-up data included repeated serology and biopsy results when performed. Minimum follow-up was 12 months unless celiac disease (CeD) was diagnosed earlier. Results: PCD was diagnosed in 90 children (71% females) with a mean age of 7.2 (range 1.8–16.5) years. Baseline anti-tissue transglutaminase (TTG) levels were above 10 times the upper limit of normal (ULN) in 17/90 (18.9%), 3–10 × ULN in 56/90 (62.2%) and 1–3 × ULN in 17/90 (18.9%). During follow-up, the mean time was 17.6 (range 5–35) months, TTG normalized in 34/90 (37.8%), was stable in 48/90 (53.3%), and increased or remained >10 × ULN in 8/90 (8.9%). In 20/90 (22.2%) patients, a repeat endoscopy was performed, leading to CeD diagnosis in 12/20 (60%). Thus, at the end of follow-up, CeD was diagnosed in 12/90 (13.3%). In patients with TTG >10 × ULN at diagnosis, TTG normalized in 5/17, decreased to 3–10 × ULN in 8/17, and remained above 10 × ULN in 4/17. Conclusions: During the short-term follow-up of pediatric PCD patients, less than 15% progressed to CeD. A third had normalized TTG levels, including children with TTG >10 × ULN, indicating the need for periodic serological and histological follow-up among PCD patients.
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spelling pubmed-103832872023-07-30 Characterization and Short-Term Outcome of Potential Celiac Disease in Children Kori, Michal Topf-Olivestone, Chani Rinawi, Firas Lev-Tzion, Raffi Ziv-Sokolovskaya, Nadya Lapidot Alon, Noy Guz-Mark, Anat Shamir, Raanan Medicina (Kaunas) Article Background and Objectives: Potential Celiac Disease (PCD) is defined by positive celiac serology without villous atrophy. We aimed to describe the short-term outcome of pediatric PCD while consuming a gluten-containing diet (GCD). Materials and Methods: Retrospective analysis of pediatric PCD patients continuing GCD, between December 2018–January 2022. Baseline demographics, celiac serology and duodenal biopsy results were reviewed. Follow-up data included repeated serology and biopsy results when performed. Minimum follow-up was 12 months unless celiac disease (CeD) was diagnosed earlier. Results: PCD was diagnosed in 90 children (71% females) with a mean age of 7.2 (range 1.8–16.5) years. Baseline anti-tissue transglutaminase (TTG) levels were above 10 times the upper limit of normal (ULN) in 17/90 (18.9%), 3–10 × ULN in 56/90 (62.2%) and 1–3 × ULN in 17/90 (18.9%). During follow-up, the mean time was 17.6 (range 5–35) months, TTG normalized in 34/90 (37.8%), was stable in 48/90 (53.3%), and increased or remained >10 × ULN in 8/90 (8.9%). In 20/90 (22.2%) patients, a repeat endoscopy was performed, leading to CeD diagnosis in 12/20 (60%). Thus, at the end of follow-up, CeD was diagnosed in 12/90 (13.3%). In patients with TTG >10 × ULN at diagnosis, TTG normalized in 5/17, decreased to 3–10 × ULN in 8/17, and remained above 10 × ULN in 4/17. Conclusions: During the short-term follow-up of pediatric PCD patients, less than 15% progressed to CeD. A third had normalized TTG levels, including children with TTG >10 × ULN, indicating the need for periodic serological and histological follow-up among PCD patients. MDPI 2023-06-21 /pmc/articles/PMC10383287/ /pubmed/37511994 http://dx.doi.org/10.3390/medicina59071182 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kori, Michal
Topf-Olivestone, Chani
Rinawi, Firas
Lev-Tzion, Raffi
Ziv-Sokolovskaya, Nadya
Lapidot Alon, Noy
Guz-Mark, Anat
Shamir, Raanan
Characterization and Short-Term Outcome of Potential Celiac Disease in Children
title Characterization and Short-Term Outcome of Potential Celiac Disease in Children
title_full Characterization and Short-Term Outcome of Potential Celiac Disease in Children
title_fullStr Characterization and Short-Term Outcome of Potential Celiac Disease in Children
title_full_unstemmed Characterization and Short-Term Outcome of Potential Celiac Disease in Children
title_short Characterization and Short-Term Outcome of Potential Celiac Disease in Children
title_sort characterization and short-term outcome of potential celiac disease in children
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10383287/
https://www.ncbi.nlm.nih.gov/pubmed/37511994
http://dx.doi.org/10.3390/medicina59071182
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