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Short Review on the Biological Activity of Cyclodextrin-Drug Inclusion Complexes Applicable in Veterinary Therapy

Cyclodextrins (CDs) are a family of carrier molecules used to improve the pharmacokinetic parameters of therapeutic molecules. These cyclic oligosaccharides have medical and pharmaceutical applications by being able to form inclusion complexes with molecules that are poorly soluble in water. The ben...

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Autores principales: Grecu, Mariana, Minea, Bogdan, Foia, Liliana-Georgeta, Bostanaru-Iliescu, Andra-Cristina, Miron, Liviu, Nastasa, Valentin, Mares, Mihai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10383344/
https://www.ncbi.nlm.nih.gov/pubmed/37513437
http://dx.doi.org/10.3390/molecules28145565
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author Grecu, Mariana
Minea, Bogdan
Foia, Liliana-Georgeta
Bostanaru-Iliescu, Andra-Cristina
Miron, Liviu
Nastasa, Valentin
Mares, Mihai
author_facet Grecu, Mariana
Minea, Bogdan
Foia, Liliana-Georgeta
Bostanaru-Iliescu, Andra-Cristina
Miron, Liviu
Nastasa, Valentin
Mares, Mihai
author_sort Grecu, Mariana
collection PubMed
description Cyclodextrins (CDs) are a family of carrier molecules used to improve the pharmacokinetic parameters of therapeutic molecules. These cyclic oligosaccharides have medical and pharmaceutical applications by being able to form inclusion complexes with molecules that are poorly soluble in water. The benefits of these complexes are directed towards improving the chemical and biological properties—i.e., solubility, bioavailability, stability, non-toxicity and shelf life of drug molecules. Since the 1960s, the first inclusion complexes used in therapeutics were those with α-, β- and γ-CD, which proved their usefulness, but had certain degrees of particularly renal toxicity. Currently, to correct these deficiencies, β-CD derivatives are most frequently used, such as sulfobutylether-β-CD, hydroxypropyl-β-CD, etc. Therefore, it is of interest to bring to the attention of those interested the diversity of current and potential future clinical applications of inclusion complexes in veterinary medicine and to present the contribution of these inclusion complexes in improving drug efficacy. The most important biological activities of β-CD complexed molecules in the veterinary field are summarized in this short review.
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spelling pubmed-103833442023-07-30 Short Review on the Biological Activity of Cyclodextrin-Drug Inclusion Complexes Applicable in Veterinary Therapy Grecu, Mariana Minea, Bogdan Foia, Liliana-Georgeta Bostanaru-Iliescu, Andra-Cristina Miron, Liviu Nastasa, Valentin Mares, Mihai Molecules Review Cyclodextrins (CDs) are a family of carrier molecules used to improve the pharmacokinetic parameters of therapeutic molecules. These cyclic oligosaccharides have medical and pharmaceutical applications by being able to form inclusion complexes with molecules that are poorly soluble in water. The benefits of these complexes are directed towards improving the chemical and biological properties—i.e., solubility, bioavailability, stability, non-toxicity and shelf life of drug molecules. Since the 1960s, the first inclusion complexes used in therapeutics were those with α-, β- and γ-CD, which proved their usefulness, but had certain degrees of particularly renal toxicity. Currently, to correct these deficiencies, β-CD derivatives are most frequently used, such as sulfobutylether-β-CD, hydroxypropyl-β-CD, etc. Therefore, it is of interest to bring to the attention of those interested the diversity of current and potential future clinical applications of inclusion complexes in veterinary medicine and to present the contribution of these inclusion complexes in improving drug efficacy. The most important biological activities of β-CD complexed molecules in the veterinary field are summarized in this short review. MDPI 2023-07-21 /pmc/articles/PMC10383344/ /pubmed/37513437 http://dx.doi.org/10.3390/molecules28145565 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Grecu, Mariana
Minea, Bogdan
Foia, Liliana-Georgeta
Bostanaru-Iliescu, Andra-Cristina
Miron, Liviu
Nastasa, Valentin
Mares, Mihai
Short Review on the Biological Activity of Cyclodextrin-Drug Inclusion Complexes Applicable in Veterinary Therapy
title Short Review on the Biological Activity of Cyclodextrin-Drug Inclusion Complexes Applicable in Veterinary Therapy
title_full Short Review on the Biological Activity of Cyclodextrin-Drug Inclusion Complexes Applicable in Veterinary Therapy
title_fullStr Short Review on the Biological Activity of Cyclodextrin-Drug Inclusion Complexes Applicable in Veterinary Therapy
title_full_unstemmed Short Review on the Biological Activity of Cyclodextrin-Drug Inclusion Complexes Applicable in Veterinary Therapy
title_short Short Review on the Biological Activity of Cyclodextrin-Drug Inclusion Complexes Applicable in Veterinary Therapy
title_sort short review on the biological activity of cyclodextrin-drug inclusion complexes applicable in veterinary therapy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10383344/
https://www.ncbi.nlm.nih.gov/pubmed/37513437
http://dx.doi.org/10.3390/molecules28145565
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