Cargando…
Short Review on the Biological Activity of Cyclodextrin-Drug Inclusion Complexes Applicable in Veterinary Therapy
Cyclodextrins (CDs) are a family of carrier molecules used to improve the pharmacokinetic parameters of therapeutic molecules. These cyclic oligosaccharides have medical and pharmaceutical applications by being able to form inclusion complexes with molecules that are poorly soluble in water. The ben...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10383344/ https://www.ncbi.nlm.nih.gov/pubmed/37513437 http://dx.doi.org/10.3390/molecules28145565 |
_version_ | 1785080886616653824 |
---|---|
author | Grecu, Mariana Minea, Bogdan Foia, Liliana-Georgeta Bostanaru-Iliescu, Andra-Cristina Miron, Liviu Nastasa, Valentin Mares, Mihai |
author_facet | Grecu, Mariana Minea, Bogdan Foia, Liliana-Georgeta Bostanaru-Iliescu, Andra-Cristina Miron, Liviu Nastasa, Valentin Mares, Mihai |
author_sort | Grecu, Mariana |
collection | PubMed |
description | Cyclodextrins (CDs) are a family of carrier molecules used to improve the pharmacokinetic parameters of therapeutic molecules. These cyclic oligosaccharides have medical and pharmaceutical applications by being able to form inclusion complexes with molecules that are poorly soluble in water. The benefits of these complexes are directed towards improving the chemical and biological properties—i.e., solubility, bioavailability, stability, non-toxicity and shelf life of drug molecules. Since the 1960s, the first inclusion complexes used in therapeutics were those with α-, β- and γ-CD, which proved their usefulness, but had certain degrees of particularly renal toxicity. Currently, to correct these deficiencies, β-CD derivatives are most frequently used, such as sulfobutylether-β-CD, hydroxypropyl-β-CD, etc. Therefore, it is of interest to bring to the attention of those interested the diversity of current and potential future clinical applications of inclusion complexes in veterinary medicine and to present the contribution of these inclusion complexes in improving drug efficacy. The most important biological activities of β-CD complexed molecules in the veterinary field are summarized in this short review. |
format | Online Article Text |
id | pubmed-10383344 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-103833442023-07-30 Short Review on the Biological Activity of Cyclodextrin-Drug Inclusion Complexes Applicable in Veterinary Therapy Grecu, Mariana Minea, Bogdan Foia, Liliana-Georgeta Bostanaru-Iliescu, Andra-Cristina Miron, Liviu Nastasa, Valentin Mares, Mihai Molecules Review Cyclodextrins (CDs) are a family of carrier molecules used to improve the pharmacokinetic parameters of therapeutic molecules. These cyclic oligosaccharides have medical and pharmaceutical applications by being able to form inclusion complexes with molecules that are poorly soluble in water. The benefits of these complexes are directed towards improving the chemical and biological properties—i.e., solubility, bioavailability, stability, non-toxicity and shelf life of drug molecules. Since the 1960s, the first inclusion complexes used in therapeutics were those with α-, β- and γ-CD, which proved their usefulness, but had certain degrees of particularly renal toxicity. Currently, to correct these deficiencies, β-CD derivatives are most frequently used, such as sulfobutylether-β-CD, hydroxypropyl-β-CD, etc. Therefore, it is of interest to bring to the attention of those interested the diversity of current and potential future clinical applications of inclusion complexes in veterinary medicine and to present the contribution of these inclusion complexes in improving drug efficacy. The most important biological activities of β-CD complexed molecules in the veterinary field are summarized in this short review. MDPI 2023-07-21 /pmc/articles/PMC10383344/ /pubmed/37513437 http://dx.doi.org/10.3390/molecules28145565 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Grecu, Mariana Minea, Bogdan Foia, Liliana-Georgeta Bostanaru-Iliescu, Andra-Cristina Miron, Liviu Nastasa, Valentin Mares, Mihai Short Review on the Biological Activity of Cyclodextrin-Drug Inclusion Complexes Applicable in Veterinary Therapy |
title | Short Review on the Biological Activity of Cyclodextrin-Drug Inclusion Complexes Applicable in Veterinary Therapy |
title_full | Short Review on the Biological Activity of Cyclodextrin-Drug Inclusion Complexes Applicable in Veterinary Therapy |
title_fullStr | Short Review on the Biological Activity of Cyclodextrin-Drug Inclusion Complexes Applicable in Veterinary Therapy |
title_full_unstemmed | Short Review on the Biological Activity of Cyclodextrin-Drug Inclusion Complexes Applicable in Veterinary Therapy |
title_short | Short Review on the Biological Activity of Cyclodextrin-Drug Inclusion Complexes Applicable in Veterinary Therapy |
title_sort | short review on the biological activity of cyclodextrin-drug inclusion complexes applicable in veterinary therapy |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10383344/ https://www.ncbi.nlm.nih.gov/pubmed/37513437 http://dx.doi.org/10.3390/molecules28145565 |
work_keys_str_mv | AT grecumariana shortreviewonthebiologicalactivityofcyclodextrindruginclusioncomplexesapplicableinveterinarytherapy AT mineabogdan shortreviewonthebiologicalactivityofcyclodextrindruginclusioncomplexesapplicableinveterinarytherapy AT foialilianageorgeta shortreviewonthebiologicalactivityofcyclodextrindruginclusioncomplexesapplicableinveterinarytherapy AT bostanaruiliescuandracristina shortreviewonthebiologicalactivityofcyclodextrindruginclusioncomplexesapplicableinveterinarytherapy AT mironliviu shortreviewonthebiologicalactivityofcyclodextrindruginclusioncomplexesapplicableinveterinarytherapy AT nastasavalentin shortreviewonthebiologicalactivityofcyclodextrindruginclusioncomplexesapplicableinveterinarytherapy AT maresmihai shortreviewonthebiologicalactivityofcyclodextrindruginclusioncomplexesapplicableinveterinarytherapy |