Cargando…

Genetic Profile of African Swine Fever Viruses Circulating at Pig Farms in South Korea during the Outbreaks between 2022 and April 2023

Fifteen pig farms were affected by African swine fever (ASF) in South Korea during the outbreaks between 2022 and April 2023. The ASF virus (ASFV) genome was directly extracted from the blood and tissue samples of 15 ASFV-positive pig farms to analyze the genetic characteristics. Phylogenetic analys...

Descripción completa

Detalles Bibliográficos
Autores principales: Cho, Ki-Hyun, Yoo, Dae-Sung, Hong, Seong-Keun, Kim, Da-Young, Jang, Min-Kyung, Kang, Hae-Eun, Kim, Yeon-Hee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10383346/
https://www.ncbi.nlm.nih.gov/pubmed/37515238
http://dx.doi.org/10.3390/v15071552
_version_ 1785080887096901632
author Cho, Ki-Hyun
Yoo, Dae-Sung
Hong, Seong-Keun
Kim, Da-Young
Jang, Min-Kyung
Kang, Hae-Eun
Kim, Yeon-Hee
author_facet Cho, Ki-Hyun
Yoo, Dae-Sung
Hong, Seong-Keun
Kim, Da-Young
Jang, Min-Kyung
Kang, Hae-Eun
Kim, Yeon-Hee
author_sort Cho, Ki-Hyun
collection PubMed
description Fifteen pig farms were affected by African swine fever (ASF) in South Korea during the outbreaks between 2022 and April 2023. The ASF virus (ASFV) genome was directly extracted from the blood and tissue samples of 15 ASFV-positive pig farms to analyze the genetic characteristics. Phylogenetic analysis revealed that the 15 strains belonged to p72 genotype II and CD2v serogroup 8, which were the central variable region (CVR) I variants of the B602L gene. Fourteen strains were intergenic region (IGR) II variants, containing an additional tandem repeat sequence (TRS), between I73L and I329R, with the exception of one strain from an ASFV-infected pig farm reported on 22 January 2023, which was an IGR I variant. In addition, a single-nucleotide polymorphism (SNP) was detected at position 107 from the start of the IGR between A179L and A137R in six isolates. The findings of this study suggest that the sources of the virus at the pig farms from which these variants originated differed from those of other pig farms.
format Online
Article
Text
id pubmed-10383346
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-103833462023-07-30 Genetic Profile of African Swine Fever Viruses Circulating at Pig Farms in South Korea during the Outbreaks between 2022 and April 2023 Cho, Ki-Hyun Yoo, Dae-Sung Hong, Seong-Keun Kim, Da-Young Jang, Min-Kyung Kang, Hae-Eun Kim, Yeon-Hee Viruses Brief Report Fifteen pig farms were affected by African swine fever (ASF) in South Korea during the outbreaks between 2022 and April 2023. The ASF virus (ASFV) genome was directly extracted from the blood and tissue samples of 15 ASFV-positive pig farms to analyze the genetic characteristics. Phylogenetic analysis revealed that the 15 strains belonged to p72 genotype II and CD2v serogroup 8, which were the central variable region (CVR) I variants of the B602L gene. Fourteen strains were intergenic region (IGR) II variants, containing an additional tandem repeat sequence (TRS), between I73L and I329R, with the exception of one strain from an ASFV-infected pig farm reported on 22 January 2023, which was an IGR I variant. In addition, a single-nucleotide polymorphism (SNP) was detected at position 107 from the start of the IGR between A179L and A137R in six isolates. The findings of this study suggest that the sources of the virus at the pig farms from which these variants originated differed from those of other pig farms. MDPI 2023-07-14 /pmc/articles/PMC10383346/ /pubmed/37515238 http://dx.doi.org/10.3390/v15071552 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Brief Report
Cho, Ki-Hyun
Yoo, Dae-Sung
Hong, Seong-Keun
Kim, Da-Young
Jang, Min-Kyung
Kang, Hae-Eun
Kim, Yeon-Hee
Genetic Profile of African Swine Fever Viruses Circulating at Pig Farms in South Korea during the Outbreaks between 2022 and April 2023
title Genetic Profile of African Swine Fever Viruses Circulating at Pig Farms in South Korea during the Outbreaks between 2022 and April 2023
title_full Genetic Profile of African Swine Fever Viruses Circulating at Pig Farms in South Korea during the Outbreaks between 2022 and April 2023
title_fullStr Genetic Profile of African Swine Fever Viruses Circulating at Pig Farms in South Korea during the Outbreaks between 2022 and April 2023
title_full_unstemmed Genetic Profile of African Swine Fever Viruses Circulating at Pig Farms in South Korea during the Outbreaks between 2022 and April 2023
title_short Genetic Profile of African Swine Fever Viruses Circulating at Pig Farms in South Korea during the Outbreaks between 2022 and April 2023
title_sort genetic profile of african swine fever viruses circulating at pig farms in south korea during the outbreaks between 2022 and april 2023
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10383346/
https://www.ncbi.nlm.nih.gov/pubmed/37515238
http://dx.doi.org/10.3390/v15071552
work_keys_str_mv AT chokihyun geneticprofileofafricanswinefevervirusescirculatingatpigfarmsinsouthkoreaduringtheoutbreaksbetween2022andapril2023
AT yoodaesung geneticprofileofafricanswinefevervirusescirculatingatpigfarmsinsouthkoreaduringtheoutbreaksbetween2022andapril2023
AT hongseongkeun geneticprofileofafricanswinefevervirusescirculatingatpigfarmsinsouthkoreaduringtheoutbreaksbetween2022andapril2023
AT kimdayoung geneticprofileofafricanswinefevervirusescirculatingatpigfarmsinsouthkoreaduringtheoutbreaksbetween2022andapril2023
AT jangminkyung geneticprofileofafricanswinefevervirusescirculatingatpigfarmsinsouthkoreaduringtheoutbreaksbetween2022andapril2023
AT kanghaeeun geneticprofileofafricanswinefevervirusescirculatingatpigfarmsinsouthkoreaduringtheoutbreaksbetween2022andapril2023
AT kimyeonhee geneticprofileofafricanswinefevervirusescirculatingatpigfarmsinsouthkoreaduringtheoutbreaksbetween2022andapril2023