Cargando…

Budesonide Analogues Preserve Stem Cell Pluripotency and Delay 3D Gastruloid Development

Small molecules that can modulate or stabilize cell–cell interactions are valuable tools for investigating the impact of collective cell behavior on various biological processes such as development/morphogenesis, tissue regeneration and cancer progression. Recently, we showed that budesonide, a gluc...

Descripción completa

Detalles Bibliográficos
Autores principales:	Amoroso, Filomena, Ibello, Eduardo, Saracino, Federica, Cermola, Federica, Ponticelli, Giovanna, Scalera, Enrica, Ricci, Francesca, Villetti, Gino, Cobellis, Gilda, Minchiotti, Gabriella, Patriarca, Eduardo Jorge, De Cesare, Dario, D’Aniello, Cristina
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10383393/ https://www.ncbi.nlm.nih.gov/pubmed/37514083 http://dx.doi.org/10.3390/pharmaceutics15071897

Ejemplares similares

Stabilization of cell-cell adhesions prevents symmetry breaking and locks in pluripotency in 3D gastruloids
por: Cermola, Federica, et al.
Publicado: (2022)

Gastruloid Development Competence Discriminates Different States of Pluripotency
por: Cermola, Federica, et al.
Publicado: (2021)

Vitamin C in Stem Cell Biology: Impact on Extracellular Matrix Homeostasis and Epigenetics
por: D'Aniello, Cristina, et al.
Publicado: (2017)

Metabolic–Epigenetic Axis in Pluripotent State Transitions
por: D’Aniello, Cristina, et al.
Publicado: (2019)

The Multifaceted Roles of Proline in Cell Behavior
por: Patriarca, Eduardo J., et al.
Publicado: (2021)

Vitamin C and l-Proline Antagonistic Effects Capture Alternative States in the Pluripotency Continuum
por: D'Aniello, Cristina, et al.
Publicado: (2016)

A novel autoregulatory loop between the Gcn2-Atf4 pathway and L-Proline metabolism controls stem cell identity
por: D'Aniello, C, et al.
Publicado: (2015)

Proline Metabolism in Tumor Growth and Metastatic Progression
por: D'Aniello, Cristina, et al.
Publicado: (2020)

Capturing Transitional Pluripotency through Proline Metabolism
por: Minchiotti, Gabriella, et al.
Publicado: (2022)

Multimodal characterization of murine gastruloid development
por: Suppinger, Simon, et al.
Publicado: (2023)

A combined human gastruloid model of cardiogenesis and neurogenesis
por: Olmsted, Zachary T., et al.
Publicado: (2022)

Cripto is essential to capture mouse epiblast stem cell and human embryonic stem cell pluripotency
por: Fiorenzano, Alessandro, et al.
Publicado: (2016)

Cardiac Organoids and Gastruloids to Study Physio-Pathological Heart Development
por: Jaconi, Marisa E., et al.
Publicado: (2021)

Generation of human elongating multi-lineage organized cardiac gastruloids
por: Olmsted, Zachary T., et al.
Publicado: (2022)

Recording morphogen signals reveals origins of gastruloid symmetry breaking
por: McNamara, Harold M., et al.
Publicado: (2023)

Gastruloids as in vitro models of embryonic blood development with spatial and temporal resolution
por: Rossi, Giuliana, et al.
Publicado: (2022)

A New Approach to Generate Gastruloids to Develop Anterior Neural Tissues
por: Girgin, Mehmet, et al.
Publicado: (2023)

Lack of Sik1 in Mouse Embryonic Stem Cells Impairs Cardiomyogenesis by Down-Regulating the Cyclin-Dependent Kinase Inhibitor p57(kip2)
por: Romito, Antonio, et al.
Publicado: (2010)

WNT signaling memory is required for ACTIVIN to function as a morphogen in human gastruloids
por: Yoney, Anna, et al.
Publicado: (2018)

Gastruloids generated without exogenous Wnt activation develop anterior neural tissues
por: Girgin, Mehmet U., et al.
Publicado: (2021)

A gastruloid model of the interaction between embryonic and extra-embryonic cell types
por: Bérenger-Currias, Noémie MLP, et al.
Publicado: (2022)

Long non-coding RNA in stem cell pluripotency and lineage commitment: functions and evolutionary conservation
por: Fico, Annalisa, et al.
Publicado: (2019)

LncRNAs and PRC2: Coupled Partners in Embryonic Stem Cells
por: Fiorenzano, Alessandro, et al.
Publicado: (2019)

In vitro teratogenicity testing using a 3D, embryo-like gastruloid system
por: Mantziou, Veronika, et al.
Publicado: (2021)

YAP1 regulates the self-organized fate patterning of hESC-derived gastruloids
por: Stronati, Eleonora, et al.
Publicado: (2022)

Cell-state transitions and collective cell movement generate an endoderm-like region in gastruloids
por: Hashmi, Ali, et al.
Publicado: (2022)

High-resolution transcriptional and morphogenetic profiling of cells from micropatterned human ESC gastruloid cultures
por: Minn, Kyaw Thu, et al.
Publicado: (2020)

Hypoxia induces an early primitive streak signature, enhancing spontaneous elongation and lineage representation in gastruloids
por: López-Anguita, Natalia, et al.
Publicado: (2022)

Gastruloid-derived primordial germ cell-like cells develop dynamically within integrated tissues
por: Cooke, Christopher B., et al.
Publicado: (2023)

Nodal is a short-range morphogen with activity that spreads through a relay mechanism in human gastruloids
por: Liu, Lizhong, et al.
Publicado: (2022)

Co-development of central and peripheral neurons with trunk mesendoderm in human elongating multi-lineage organized gastruloids
por: Olmsted, Zachary T., et al.
Publicado: (2021)

Anteroposterior polarity and elongation in the absence of extra-embryonic tissues and of spatially localised signalling in gastruloids: mammalian embryonic organoids
por: Turner, David A., et al.
Publicado: (2017)

TBXT dose sensitivity and the decoupling of nascent mesoderm specification from EMT progression in 2D human gastruloids
por: Bulger, Emily A., et al.
Publicado: (2023)

Therapeutic comparison of a new budesonide/formoterol pMDI with budesonide pMDI and budesonide/formoterol DPI in asthma
por: Morice, A H, et al.
Publicado: (2007)

Could cognitive estimation ability be a measure of cognitive reserve?
por: D'Aniello, Guido E., et al.
Publicado: (2015)

FISH for All: A Fast and Efficient Fluorescent In situ Hybridization (FISH) Protocol for Marine Embryos and Larvae
por: Paganos, Periklis, et al.
Publicado: (2022)

Dissecting the dynamics of signaling events in the BMP, WNT, and NODAL cascade during self-organized fate patterning in human gastruloids
por: Chhabra, Sapna, et al.
Publicado: (2019)

Huntingtin CAG expansion impairs germ layer patterning in synthetic human 2D gastruloids through polarity defects
por: Galgoczi, Szilvia, et al.
Publicado: (2021)

Gene expression dynamics underlying cell fate emergence in 2D micropatterned human embryonic stem cell gastruloids
por: Minn, Kyaw Thu, et al.
Publicado: (2021)

Nasal irrigation with corticosteroids in Brazil: the clinical response of 1% compounded budesonide drops and betamethasone cream
por: Luz-Matsumoto, Gabriela Ricci, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_lboi4p5u5cq168e3flt8bsjm2m