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Impact of SARS-CoV-2 Infection in Children with Asthma and Impact of COVID-19 Vaccination: Current Evidence and Review of the Literature

The clinical aspects of SARS-CoV-2 infection, as well as the COVID-19 vaccines’ safety, efficacy and effectiveness in pediatric patients with asthma, are crucial to adapting clinical management in this fragile population and for prevention strategies. The aim of this narrative review was to evaluate...

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Autores principales: Grandinetti, Roberto, Palazzolo, Elisabetta, Rizzo, Luisa, Carbone, Roberta, Pisi, Giovanna, Fainardi, Valentina, Esposito, Susanna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10383403/
https://www.ncbi.nlm.nih.gov/pubmed/37512917
http://dx.doi.org/10.3390/microorganisms11071745
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author Grandinetti, Roberto
Palazzolo, Elisabetta
Rizzo, Luisa
Carbone, Roberta
Pisi, Giovanna
Fainardi, Valentina
Esposito, Susanna
author_facet Grandinetti, Roberto
Palazzolo, Elisabetta
Rizzo, Luisa
Carbone, Roberta
Pisi, Giovanna
Fainardi, Valentina
Esposito, Susanna
author_sort Grandinetti, Roberto
collection PubMed
description The clinical aspects of SARS-CoV-2 infection, as well as the COVID-19 vaccines’ safety, efficacy and effectiveness in pediatric patients with asthma, are crucial to adapting clinical management in this fragile population and for prevention strategies. The aim of this narrative review was to evaluate the impact of SARS-CoV-2 infection in children with asthma and the impact of COVID-19 vaccination. Systematic research using the principal medical databases was conducted using specific search query strings from the early spreading of COVID-19 globally until March 2023; further relevant data were drawn from the main national and supranational institutions. No significant differences in SARS-CoV-2 incidence and morbidity were found in asthmatic pediatric patients compared to non-asthmatic ones; however, subjects with uncontrolled asthma were found to be at increased risk of developing a serious disease during SARS-CoV-2 infection. Regarding COVID-19 vaccines, accumulating data support their safety, efficacy and effectiveness on asthmatic children regardless of asthma severity. Further cohort-based studies are needed as the evidence of new epidemic waves caused by new viral variants makes the current knowledge outdated.
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spelling pubmed-103834032023-07-30 Impact of SARS-CoV-2 Infection in Children with Asthma and Impact of COVID-19 Vaccination: Current Evidence and Review of the Literature Grandinetti, Roberto Palazzolo, Elisabetta Rizzo, Luisa Carbone, Roberta Pisi, Giovanna Fainardi, Valentina Esposito, Susanna Microorganisms Review The clinical aspects of SARS-CoV-2 infection, as well as the COVID-19 vaccines’ safety, efficacy and effectiveness in pediatric patients with asthma, are crucial to adapting clinical management in this fragile population and for prevention strategies. The aim of this narrative review was to evaluate the impact of SARS-CoV-2 infection in children with asthma and the impact of COVID-19 vaccination. Systematic research using the principal medical databases was conducted using specific search query strings from the early spreading of COVID-19 globally until March 2023; further relevant data were drawn from the main national and supranational institutions. No significant differences in SARS-CoV-2 incidence and morbidity were found in asthmatic pediatric patients compared to non-asthmatic ones; however, subjects with uncontrolled asthma were found to be at increased risk of developing a serious disease during SARS-CoV-2 infection. Regarding COVID-19 vaccines, accumulating data support their safety, efficacy and effectiveness on asthmatic children regardless of asthma severity. Further cohort-based studies are needed as the evidence of new epidemic waves caused by new viral variants makes the current knowledge outdated. MDPI 2023-07-04 /pmc/articles/PMC10383403/ /pubmed/37512917 http://dx.doi.org/10.3390/microorganisms11071745 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Grandinetti, Roberto
Palazzolo, Elisabetta
Rizzo, Luisa
Carbone, Roberta
Pisi, Giovanna
Fainardi, Valentina
Esposito, Susanna
Impact of SARS-CoV-2 Infection in Children with Asthma and Impact of COVID-19 Vaccination: Current Evidence and Review of the Literature
title Impact of SARS-CoV-2 Infection in Children with Asthma and Impact of COVID-19 Vaccination: Current Evidence and Review of the Literature
title_full Impact of SARS-CoV-2 Infection in Children with Asthma and Impact of COVID-19 Vaccination: Current Evidence and Review of the Literature
title_fullStr Impact of SARS-CoV-2 Infection in Children with Asthma and Impact of COVID-19 Vaccination: Current Evidence and Review of the Literature
title_full_unstemmed Impact of SARS-CoV-2 Infection in Children with Asthma and Impact of COVID-19 Vaccination: Current Evidence and Review of the Literature
title_short Impact of SARS-CoV-2 Infection in Children with Asthma and Impact of COVID-19 Vaccination: Current Evidence and Review of the Literature
title_sort impact of sars-cov-2 infection in children with asthma and impact of covid-19 vaccination: current evidence and review of the literature
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10383403/
https://www.ncbi.nlm.nih.gov/pubmed/37512917
http://dx.doi.org/10.3390/microorganisms11071745
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