Cargando…

Computational Modeling, High-Level Soluble Expression and In Vitro Cytotoxicity Assessment of Recombinant Pseudomonas aeruginosa Azurin: A Promising Anti-Cancer Therapeutic Candidate

Azurin is a natural protein produced by Pseudomonas aeruginosa that exhibits potential anti-tumor, anti-HIV, and anti-parasitic properties. The current study aimed to investigate the potential of azurin protein against breast cancer using both in silico and in vitro analyses. The amino acid sequence...

Descripción completa

Detalles Bibliográficos
Autores principales:	Aslam, Shakira, Rehman, Hafiz Muzzammel, Sarwar, Muhammad Zeeshan, Ahmad, Ajaz, Ahmed, Nadeem, Amirzada, Muhammad Imran, Rehman, Hafiz Muhammad, Yasmin, Humaira, Nadeem, Tariq, Bashir, Hamid
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10383417/ https://www.ncbi.nlm.nih.gov/pubmed/37514012 http://dx.doi.org/10.3390/pharmaceutics15071825

Ejemplares similares

In Silico Investigation of a Chimeric IL24-LK6 Fusion Protein as a Potent Candidate Against Breast Cancer
por: Muhammad Rehman, Hafiz, et al.
Publicado: (2023)

In Vitro Antidiabetic, Anti-Obesity and Antioxidant Analysis of Ocimum basilicum Aerial Biomass and in Silico Molecular Docking Simulations with Alpha-Amylase and Lipase Enzymes
por: Noor, Zoy I, et al.
Publicado: (2019)

2-(Prop-2-enyl)-1,2-benzisothiazol-3(2H)-one 1,1-dioxide
por: Arshad, Muhammad Nadeem, et al.
Publicado: (2009)

2-[(E)-3-Phenylprop-2-enyl]-1,2-benzisothiazol-3(2H)-one 1,1-dioxide
por: Arshad, Muhammad Nadeem, et al.
Publicado: (2009)

Molecular Characterization, Structural Modeling, and Evaluation of Antimicrobial Activity of Basrai Thaumatin-Like Protein against Fungal Infection
por: Yasmin, Nusrat, et al.
Publicado: (2017)

Antagonistic, Anti-oxidant, Anti-inflammatory and Anti-diabetic Probiotic Potential of Lactobacillus agilis Isolated From the Rhizosphere of the Medicinal Plants
por: Khan, Allah Nawaz, et al.
Publicado: (2021)

Enhanced Thermostability and Enzymatic Activity of cel6A Variants from Thermobifida fusca by Empirical Domain Engineering
por: Ali, Imran, et al.
Publicado: (2020)

Analysis of antibacterial and antibiofilm activity of purified recombinant Azurin from Pseudomonas aeruginosa
por: Mohammadi-Barzelighi, Hajar, et al.
Publicado: (2019)

Promising features of Moringa oleifera oil: recent updates and perspectives
por: Nadeem, Muhammad, et al.
Publicado: (2016)

All-Cause Mortality Outcomes of Usage of Cardiac Contractility Modulation in Patients With Dilated Cardiomyopathy Ineligible for Cardiac Re-Synchronization Therapy: An Updated Meta-Analysis of Randomized Controlled Trials
por: Nadeem, Muhammad, et al.
Publicado: (2020)

Risk Factors Associated With Birth Asphyxia in Term Newborns at a Tertiary Care Hospital of Multan, Pakistan
por: Nadeem, Ghazanfar, et al.
Publicado: (2021)

Oxidative stability and Sensoric acceptability of functional fish meat product supplemented with plant(−)based polyphenolic optimal extracts
por: Ali, Muhammad, et al.
Publicado: (2019)

N-(p-Tolylsulfonyl)-l-asparagine
por: Arshad, Muhammad Nadeem, et al.
Publicado: (2010)

N-(Phenylsulfonyl)-l-asparagine
por: Arshad, Muhammad Nadeem, et al.
Publicado: (2009)

2-(Naphthalene-2-sulfonamido)-3-phenylpropanoic acid
por: Mubashar-ur-Rehman, Hafiz, et al.
Publicado: (2013)

Mechanistic insight of the potential of geraniol against Alzheimer’s disease
por: Liu, Ying, et al.
Publicado: (2022)

Single electron transfer events and dynamical heterogeneity in the small protein azurin from Pseudomonas aeruginosa
por: Pradhan, Biswajit, et al.
Publicado: (2019)

(2S)-3-Carbamoyl-2-(4-methoxybenzenesulfonamido)propanoic acid
por: Mubashar-ur-Rehman, Hafiz, et al.
Publicado: (2010)

(2S)-3-(1H-Indol-3-yl)-2-(4-methylbenzenesulfonamido)propionic acid monohydrate
por: Khan, Islam Ullah, et al.
Publicado: (2011)

2-(3-Methylbut-2-en-1-yl)-1,2-benzisothiazol-3(2H)-one 1,1-dioxide
por: Arshad, Muhammad Nadeem, et al.
Publicado: (2009)

A Putative Prophylactic Solution for COVID-19: Development of Novel Multiepitope Vaccine Candidate against SARS-COV-2 by Comprehensive Immunoinformatic and Molecular Modelling Approach
por: Rehman, Hafiz Muzzammel, et al.
Publicado: (2020)

Network Pharmacology-Based Approach Combined with Bioinformatic Analytics to Elucidate the Potential of Curcumol against Hepatocellular Carcinoma
por: Huang, Xufeng, et al.
Publicado: (2022)

Identification of RdRp inhibitors against SARS-CoV-2 through E-pharmacophore-based virtual screening, molecular docking and MD simulations approaches
por: Rehman, Hafiz Muzzammel, et al.
Publicado: (2023)

Role of Ivabradine in Patients with Heart Failure with Preserved Ejection Fraction
por: Nadeem, Muhammad, et al.
Publicado: (2020)

Seed priming with growth regulators modulates production, physiology and antioxidant defense of Indian squash (Praecitrullus fistulosus) under semi-arid conditions
por: Qamar, Rafi, et al.
Publicado: (2022)

Synthesis and studies of new purines/pyrimidine derivatives as multi-targeted agents involving various receptor sites in the immune system
por: Kaur, Gurmeet, et al.
Publicado: (2023)

N-Benzyl-N-cyclohexylbenzenesulfonamide
por: Haider, Zeeshan, et al.
Publicado: (2009)

N-Cyclohexyl-N-propylbenzenesulfonamide
por: Haider, Zeeshan, et al.
Publicado: (2009)

Advancements in the oral delivery of Docetaxel: challenges, current state-of-the-art and future trends
por: Sohail, Muhammad Farhan, et al.
Publicado: (2018)

2-Chloro-6-(2,3-dichlorobenzenesulfonamido)benzoic acid
por: Munir, Ayesha, et al.
Publicado: (2013)

Reversible S-Nitrosylation in an Engineered Azurin
por: Tian, Shiliang, et al.
Publicado: (2016)

N-Cyclohexyl-N-(prop-2-en-1-yl)benzenesulfonamide
por: Khan, Islam Ullah, et al.
Publicado: (2009)

A second monoclinic polymorph of N-cyclohexyl-N-ethylbenzenesulfonamide
por: Haider, Zeeshan, et al.
Publicado: (2009)

N-Benzyl-N-cyclohexyl-4-methylbenzenesulfonamide
por: Khan, Islam Ullah, et al.
Publicado: (2009)

N-Cyclohexyl-N-ethylbenzenesulfonamide
por: Khan, Islam Ullah, et al.
Publicado: (2009)

An Experimental and Computational Exploration on the Electronic, Spectroscopic, and Reactivity Properties of Novel Halo-Functionalized Hydrazones
por: Ali, Akbar, et al.
Publicado: (2020)

Global Sequence Analysis and Expression of Azurin Gene in Different Clinical Specimens of Burn Patients with Pseudomonas aeruginosa Infection
por: Mohammadi Barzelighi, Hajar, et al.
Publicado: (2020)

PEGylated Protamine Letrozole Nanoparticles: A Promising Strategy to Combat Human Breast Cancer via MCF-7 Cell Lines
por: Khan, Muhammad Tafhim, et al.
Publicado: (2022)

A Case of Rapidly Deteriorating Lymphangitic Carcinomatosis in a Patient with Stage IV Pancreatic Cancer
por: Aslam, Hafiz M, et al.
Publicado: (2019)

Biocontrol of Bacterial Leaf Blight of Rice and Profiling of Secondary Metabolites Produced by Rhizospheric Pseudomonas aeruginosa BRp3
por: Yasmin, Sumera, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_oimf2mp2994k8uiptkov1kcjji