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Novel Hydrogel Membranes Based on the Bacterial Polysaccharide FucoPol: Design, Characterization and Biological Properties
FucoPol, a fucose-rich polyanionic polysaccharide, was used for the first time for the preparation of hydrogel membranes (HMs) using Fe(3+) as a crosslinking agent. This study evaluated the impact of Fe(3+) and FucoPol concentrations on the HMs’ strength. The results show that, above 1.5 g/L, Fe(3+)...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10383424/ https://www.ncbi.nlm.nih.gov/pubmed/37513903 http://dx.doi.org/10.3390/ph16070991 |
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author | Araújo, Diana Martins, Matilde Concórdio-Reis, Patrícia Roma-Rodrigues, Catarina Morais, Maria Alves, Vítor D. Fernandes, Alexandra R. Freitas, Filomena |
author_facet | Araújo, Diana Martins, Matilde Concórdio-Reis, Patrícia Roma-Rodrigues, Catarina Morais, Maria Alves, Vítor D. Fernandes, Alexandra R. Freitas, Filomena |
author_sort | Araújo, Diana |
collection | PubMed |
description | FucoPol, a fucose-rich polyanionic polysaccharide, was used for the first time for the preparation of hydrogel membranes (HMs) using Fe(3+) as a crosslinking agent. This study evaluated the impact of Fe(3+) and FucoPol concentrations on the HMs’ strength. The results show that, above 1.5 g/L, Fe(3+) concentration had a limited influence on the HMs’ strength, and varying the FucoPol concentration had a more significant effect. Three different FucoPol concentrations (1.0, 1.75 and 2.5 wt.%) were combined with Fe(3+) (1.5 g/L), resulting in HMs with a water content above 97 wt.% and an Fe(3+) content up to 0.16 wt.%. HMs with lower FucoPol content exhibited a denser porous microstructure as the polymer concentration increased. Moreover, the low polymer content HM presented the highest swelling ratio (22.3 ± 1.8 g/g) and a lower hardness value (32.4 ± 5.8 kPa). However, improved mechanical properties (221.9 ± 10.2 kPa) along with a decrease in the swelling ratio (11.9 ± 1.6 g/g) were obtained for HMs with a higher polymer content. Furthermore, all HMs were non-cytotoxic and revealed anti-inflammatory activity. The incorporation of FucoPol as a structuring agent and bioactive ingredient in the development of HMs opens up new possibilities for its use in tissue engineering, drug delivery and wound care management. |
format | Online Article Text |
id | pubmed-10383424 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-103834242023-07-30 Novel Hydrogel Membranes Based on the Bacterial Polysaccharide FucoPol: Design, Characterization and Biological Properties Araújo, Diana Martins, Matilde Concórdio-Reis, Patrícia Roma-Rodrigues, Catarina Morais, Maria Alves, Vítor D. Fernandes, Alexandra R. Freitas, Filomena Pharmaceuticals (Basel) Article FucoPol, a fucose-rich polyanionic polysaccharide, was used for the first time for the preparation of hydrogel membranes (HMs) using Fe(3+) as a crosslinking agent. This study evaluated the impact of Fe(3+) and FucoPol concentrations on the HMs’ strength. The results show that, above 1.5 g/L, Fe(3+) concentration had a limited influence on the HMs’ strength, and varying the FucoPol concentration had a more significant effect. Three different FucoPol concentrations (1.0, 1.75 and 2.5 wt.%) were combined with Fe(3+) (1.5 g/L), resulting in HMs with a water content above 97 wt.% and an Fe(3+) content up to 0.16 wt.%. HMs with lower FucoPol content exhibited a denser porous microstructure as the polymer concentration increased. Moreover, the low polymer content HM presented the highest swelling ratio (22.3 ± 1.8 g/g) and a lower hardness value (32.4 ± 5.8 kPa). However, improved mechanical properties (221.9 ± 10.2 kPa) along with a decrease in the swelling ratio (11.9 ± 1.6 g/g) were obtained for HMs with a higher polymer content. Furthermore, all HMs were non-cytotoxic and revealed anti-inflammatory activity. The incorporation of FucoPol as a structuring agent and bioactive ingredient in the development of HMs opens up new possibilities for its use in tissue engineering, drug delivery and wound care management. MDPI 2023-07-11 /pmc/articles/PMC10383424/ /pubmed/37513903 http://dx.doi.org/10.3390/ph16070991 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Araújo, Diana Martins, Matilde Concórdio-Reis, Patrícia Roma-Rodrigues, Catarina Morais, Maria Alves, Vítor D. Fernandes, Alexandra R. Freitas, Filomena Novel Hydrogel Membranes Based on the Bacterial Polysaccharide FucoPol: Design, Characterization and Biological Properties |
title | Novel Hydrogel Membranes Based on the Bacterial Polysaccharide FucoPol: Design, Characterization and Biological Properties |
title_full | Novel Hydrogel Membranes Based on the Bacterial Polysaccharide FucoPol: Design, Characterization and Biological Properties |
title_fullStr | Novel Hydrogel Membranes Based on the Bacterial Polysaccharide FucoPol: Design, Characterization and Biological Properties |
title_full_unstemmed | Novel Hydrogel Membranes Based on the Bacterial Polysaccharide FucoPol: Design, Characterization and Biological Properties |
title_short | Novel Hydrogel Membranes Based on the Bacterial Polysaccharide FucoPol: Design, Characterization and Biological Properties |
title_sort | novel hydrogel membranes based on the bacterial polysaccharide fucopol: design, characterization and biological properties |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10383424/ https://www.ncbi.nlm.nih.gov/pubmed/37513903 http://dx.doi.org/10.3390/ph16070991 |
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