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Nano- and Microemulsions in Biomedicine: From Theory to Practice
Nano- and microemulsions are colloidal systems that are widely used in various fields of biomedicine, including wound and burn healing, cosmetology, the development of antibacterial and antiviral drugs, oncology, etc. The stability of these systems is governed by the balance of molecular interaction...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10383468/ https://www.ncbi.nlm.nih.gov/pubmed/37514175 http://dx.doi.org/10.3390/pharmaceutics15071989 |
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author | Nikolaev, Boris Yakovleva, Ludmila Fedorov, Viacheslav Li, Hanmei Gao, Huile Shevtsov, Maxim |
author_facet | Nikolaev, Boris Yakovleva, Ludmila Fedorov, Viacheslav Li, Hanmei Gao, Huile Shevtsov, Maxim |
author_sort | Nikolaev, Boris |
collection | PubMed |
description | Nano- and microemulsions are colloidal systems that are widely used in various fields of biomedicine, including wound and burn healing, cosmetology, the development of antibacterial and antiviral drugs, oncology, etc. The stability of these systems is governed by the balance of molecular interactions between nanodomains. Microemulsions as a colloidal form play a special important role in stability. The microemulsion is the thermodynamically stable phase from oil, water, surfactant and co-surfactant which forms the surface of drops with very small surface energy. The last phenomena determines the shortage time of all fluid dispersions including nanoemulsions and emulgels. This review examines the theory and main methods of obtaining nano- and microemulsions, particularly focusing on the structure of microemulsions and methods for emulsion analysis. Additionally, we have analyzed the main preclinical and clinical studies in the field of wound healing and the use of emulsions in cancer therapy, emphasizing the prospects for further developments in this area. |
format | Online Article Text |
id | pubmed-10383468 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-103834682023-07-30 Nano- and Microemulsions in Biomedicine: From Theory to Practice Nikolaev, Boris Yakovleva, Ludmila Fedorov, Viacheslav Li, Hanmei Gao, Huile Shevtsov, Maxim Pharmaceutics Review Nano- and microemulsions are colloidal systems that are widely used in various fields of biomedicine, including wound and burn healing, cosmetology, the development of antibacterial and antiviral drugs, oncology, etc. The stability of these systems is governed by the balance of molecular interactions between nanodomains. Microemulsions as a colloidal form play a special important role in stability. The microemulsion is the thermodynamically stable phase from oil, water, surfactant and co-surfactant which forms the surface of drops with very small surface energy. The last phenomena determines the shortage time of all fluid dispersions including nanoemulsions and emulgels. This review examines the theory and main methods of obtaining nano- and microemulsions, particularly focusing on the structure of microemulsions and methods for emulsion analysis. Additionally, we have analyzed the main preclinical and clinical studies in the field of wound healing and the use of emulsions in cancer therapy, emphasizing the prospects for further developments in this area. MDPI 2023-07-20 /pmc/articles/PMC10383468/ /pubmed/37514175 http://dx.doi.org/10.3390/pharmaceutics15071989 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Nikolaev, Boris Yakovleva, Ludmila Fedorov, Viacheslav Li, Hanmei Gao, Huile Shevtsov, Maxim Nano- and Microemulsions in Biomedicine: From Theory to Practice |
title | Nano- and Microemulsions in Biomedicine: From Theory to Practice |
title_full | Nano- and Microemulsions in Biomedicine: From Theory to Practice |
title_fullStr | Nano- and Microemulsions in Biomedicine: From Theory to Practice |
title_full_unstemmed | Nano- and Microemulsions in Biomedicine: From Theory to Practice |
title_short | Nano- and Microemulsions in Biomedicine: From Theory to Practice |
title_sort | nano- and microemulsions in biomedicine: from theory to practice |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10383468/ https://www.ncbi.nlm.nih.gov/pubmed/37514175 http://dx.doi.org/10.3390/pharmaceutics15071989 |
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