Cargando…

Antimicrobial Resistance Genes (ARGs), the Gut Microbiome, and Infant Nutrition

The spread of antimicrobial resistance genes (ARGs) is a major public health crisis, with the ongoing spread of ARGs leading to reduced efficacy of antibiotic treatments. The gut microbiome is a key reservoir for ARGs, and because diet shapes the gut microbiome, diet also has the potential to shape...

Descripción completa

Detalles Bibliográficos
Autores principales: Theophilus, Rufus J., Taft, Diana Hazard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10383493/
https://www.ncbi.nlm.nih.gov/pubmed/37513595
http://dx.doi.org/10.3390/nu15143177
_version_ 1785080923972173824
author Theophilus, Rufus J.
Taft, Diana Hazard
author_facet Theophilus, Rufus J.
Taft, Diana Hazard
author_sort Theophilus, Rufus J.
collection PubMed
description The spread of antimicrobial resistance genes (ARGs) is a major public health crisis, with the ongoing spread of ARGs leading to reduced efficacy of antibiotic treatments. The gut microbiome is a key reservoir for ARGs, and because diet shapes the gut microbiome, diet also has the potential to shape the resistome. This diet–gut microbiome–resistome relationship may also be important in infants and young children. This narrative review examines what is known about the interaction between the infant gut microbiome, the infant resistome, and infant nutrition, including exploring the potential of diet to mitigate infant ARG carriage. While more research is needed, diet has the potential to reduce infant and toddler carriage of ARGs, an important goal as part of maintaining the efficacy of available antibiotics and preserving infant and toddler health.
format Online
Article
Text
id pubmed-10383493
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-103834932023-07-30 Antimicrobial Resistance Genes (ARGs), the Gut Microbiome, and Infant Nutrition Theophilus, Rufus J. Taft, Diana Hazard Nutrients Review The spread of antimicrobial resistance genes (ARGs) is a major public health crisis, with the ongoing spread of ARGs leading to reduced efficacy of antibiotic treatments. The gut microbiome is a key reservoir for ARGs, and because diet shapes the gut microbiome, diet also has the potential to shape the resistome. This diet–gut microbiome–resistome relationship may also be important in infants and young children. This narrative review examines what is known about the interaction between the infant gut microbiome, the infant resistome, and infant nutrition, including exploring the potential of diet to mitigate infant ARG carriage. While more research is needed, diet has the potential to reduce infant and toddler carriage of ARGs, an important goal as part of maintaining the efficacy of available antibiotics and preserving infant and toddler health. MDPI 2023-07-18 /pmc/articles/PMC10383493/ /pubmed/37513595 http://dx.doi.org/10.3390/nu15143177 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Theophilus, Rufus J.
Taft, Diana Hazard
Antimicrobial Resistance Genes (ARGs), the Gut Microbiome, and Infant Nutrition
title Antimicrobial Resistance Genes (ARGs), the Gut Microbiome, and Infant Nutrition
title_full Antimicrobial Resistance Genes (ARGs), the Gut Microbiome, and Infant Nutrition
title_fullStr Antimicrobial Resistance Genes (ARGs), the Gut Microbiome, and Infant Nutrition
title_full_unstemmed Antimicrobial Resistance Genes (ARGs), the Gut Microbiome, and Infant Nutrition
title_short Antimicrobial Resistance Genes (ARGs), the Gut Microbiome, and Infant Nutrition
title_sort antimicrobial resistance genes (args), the gut microbiome, and infant nutrition
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10383493/
https://www.ncbi.nlm.nih.gov/pubmed/37513595
http://dx.doi.org/10.3390/nu15143177
work_keys_str_mv AT theophilusrufusj antimicrobialresistancegenesargsthegutmicrobiomeandinfantnutrition
AT taftdianahazard antimicrobialresistancegenesargsthegutmicrobiomeandinfantnutrition