Experimental and Computational Investigation of the Oxime Bond Stereochemistry in c-Jun N-terminal Kinase 3 Inhibitors 11H-Indeno[1,2-b]quinoxalin-11-one Oxime and Tryptanthrin-6-oxime

11H-Indeno[1,2-b]quinoxalin-11-one oxime (IQ-1) and tryptanthrin-6-oxime are potent c-Jun N-terminal kinase 3 (JNK-3) inhibitors demonstrating neuroprotective, anti-inflammatory and anti-arthritic activity. However, the stereochemical configuration of the oxime carbon–nitrogen double bond (E- or Z-)...

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Detalles Bibliográficos
Autores principales: Matveevskaya, Vladislava V., Pavlov, Dmitry I., Kovrizhina, Anastasia R., Sukhikh, Taisiya S., Sadykov, Evgeniy H., Dorovatovskii, Pavel V., Lazarenko, Vladimir A., Khlebnikov, Andrei I., Potapov, Andrei S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10383563/
https://www.ncbi.nlm.nih.gov/pubmed/37513989
http://dx.doi.org/10.3390/pharmaceutics15071802

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