In Vitro Activity of Isavuconazole and Amphotericin B in Association against Mucorales

Mucormycoses can be treated with the combination of Amphotericin B and Isavuconazole. This study evaluates the effects of these drugs in vitro against 59 strains representing 12 Mucorales. In vitro testing of the two drugs together and alone was performed using the MIC Test strip “Epsilon test syner...

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Detalles Bibliográficos
Autores principales: Ortalli, Gaia, Oliva, Ester, Lo Cascio, Giuliana, Farina, Claudio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10383810/
https://www.ncbi.nlm.nih.gov/pubmed/37513795
http://dx.doi.org/10.3390/pathogens12070948
Descripción
Sumario:Mucormycoses can be treated with the combination of Amphotericin B and Isavuconazole. This study evaluates the effects of these drugs in vitro against 59 strains representing 12 Mucorales. In vitro testing of the two drugs together and alone was performed using the MIC Test strip “Epsilon test synergy-method” (ETSM), which is more standard in clinical practice than microbroth dilution testing. Amphotericin B and Isavuconazole have synergistic/additive effects against L. corymbifera, R. arrhizus and M. circinelloides. Different effects have been shown for other Mucorales. ETSM can help the clinical management of mucormycosis from a practical point of view, due to its feasibility in the laboratory.

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