In Vitro Activity of Isavuconazole and Amphotericin B in Association against Mucorales

Mucormycoses can be treated with the combination of Amphotericin B and Isavuconazole. This study evaluates the effects of these drugs in vitro against 59 strains representing 12 Mucorales. In vitro testing of the two drugs together and alone was performed using the MIC Test strip “Epsilon test syner...

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Detalles Bibliográficos
Autores principales: Ortalli, Gaia, Oliva, Ester, Lo Cascio, Giuliana, Farina, Claudio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10383810/
https://www.ncbi.nlm.nih.gov/pubmed/37513795
http://dx.doi.org/10.3390/pathogens12070948
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author Ortalli, Gaia
Oliva, Ester
Lo Cascio, Giuliana
Farina, Claudio
author_facet Ortalli, Gaia
Oliva, Ester
Lo Cascio, Giuliana
Farina, Claudio
author_sort Ortalli, Gaia
collection PubMed
description Mucormycoses can be treated with the combination of Amphotericin B and Isavuconazole. This study evaluates the effects of these drugs in vitro against 59 strains representing 12 Mucorales. In vitro testing of the two drugs together and alone was performed using the MIC Test strip “Epsilon test synergy-method” (ETSM), which is more standard in clinical practice than microbroth dilution testing. Amphotericin B and Isavuconazole have synergistic/additive effects against L. corymbifera, R. arrhizus and M. circinelloides. Different effects have been shown for other Mucorales. ETSM can help the clinical management of mucormycosis from a practical point of view, due to its feasibility in the laboratory.
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spelling pubmed-103838102023-07-30 In Vitro Activity of Isavuconazole and Amphotericin B in Association against Mucorales Ortalli, Gaia Oliva, Ester Lo Cascio, Giuliana Farina, Claudio Pathogens Brief Report Mucormycoses can be treated with the combination of Amphotericin B and Isavuconazole. This study evaluates the effects of these drugs in vitro against 59 strains representing 12 Mucorales. In vitro testing of the two drugs together and alone was performed using the MIC Test strip “Epsilon test synergy-method” (ETSM), which is more standard in clinical practice than microbroth dilution testing. Amphotericin B and Isavuconazole have synergistic/additive effects against L. corymbifera, R. arrhizus and M. circinelloides. Different effects have been shown for other Mucorales. ETSM can help the clinical management of mucormycosis from a practical point of view, due to its feasibility in the laboratory. MDPI 2023-07-18 /pmc/articles/PMC10383810/ /pubmed/37513795 http://dx.doi.org/10.3390/pathogens12070948 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Brief Report
Ortalli, Gaia
Oliva, Ester
Lo Cascio, Giuliana
Farina, Claudio
In Vitro Activity of Isavuconazole and Amphotericin B in Association against Mucorales
title In Vitro Activity of Isavuconazole and Amphotericin B in Association against Mucorales
title_full In Vitro Activity of Isavuconazole and Amphotericin B in Association against Mucorales
title_fullStr In Vitro Activity of Isavuconazole and Amphotericin B in Association against Mucorales
title_full_unstemmed In Vitro Activity of Isavuconazole and Amphotericin B in Association against Mucorales
title_short In Vitro Activity of Isavuconazole and Amphotericin B in Association against Mucorales
title_sort in vitro activity of isavuconazole and amphotericin b in association against mucorales
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10383810/
https://www.ncbi.nlm.nih.gov/pubmed/37513795
http://dx.doi.org/10.3390/pathogens12070948
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