Cargando…

Managing Comorbidities, Determinants and Disability at Start and End of TB Treatment under Routine Program Conditions in China

Many patients with tuberculosis (TB) have comorbidities, risk determinants and disability that co-exist at diagnosis, during and after TB treatment. We conducted an observational cohort study in 11 health facilities in China to assess under routine program conditions (i) the burden of these problems...

Descripción completa

Detalles Bibliográficos
Autores principales: Liu, Yuhong, Lin, Yan, Sun, Yuxian, Thekkur, Pruthu, Cheng, Changhao, Li, Yuecui, Shi, Yunzhen, Jiang, Jun, Liao, Jiong, Nie, Chuangui, Sun, Wenyan, Liang, Chengyuan, Zhang, Xiaojuan, Liu, Sang, Ma, Yan, Berger, Selma Dar, Satyanarayana, Srinath, Kumar, Ajay M. V., Khogali, Mohammed, Zachariah, Rony, Golub, Jonathan E., Li, Liang, Harries, Anthony D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10383887/
https://www.ncbi.nlm.nih.gov/pubmed/37505637
http://dx.doi.org/10.3390/tropicalmed8070341
_version_ 1785081021440458752
author Liu, Yuhong
Lin, Yan
Sun, Yuxian
Thekkur, Pruthu
Cheng, Changhao
Li, Yuecui
Shi, Yunzhen
Jiang, Jun
Liao, Jiong
Nie, Chuangui
Sun, Wenyan
Liang, Chengyuan
Zhang, Xiaojuan
Liu, Sang
Ma, Yan
Berger, Selma Dar
Satyanarayana, Srinath
Kumar, Ajay M. V.
Khogali, Mohammed
Zachariah, Rony
Golub, Jonathan E.
Li, Liang
Harries, Anthony D.
author_facet Liu, Yuhong
Lin, Yan
Sun, Yuxian
Thekkur, Pruthu
Cheng, Changhao
Li, Yuecui
Shi, Yunzhen
Jiang, Jun
Liao, Jiong
Nie, Chuangui
Sun, Wenyan
Liang, Chengyuan
Zhang, Xiaojuan
Liu, Sang
Ma, Yan
Berger, Selma Dar
Satyanarayana, Srinath
Kumar, Ajay M. V.
Khogali, Mohammed
Zachariah, Rony
Golub, Jonathan E.
Li, Liang
Harries, Anthony D.
author_sort Liu, Yuhong
collection PubMed
description Many patients with tuberculosis (TB) have comorbidities, risk determinants and disability that co-exist at diagnosis, during and after TB treatment. We conducted an observational cohort study in 11 health facilities in China to assess under routine program conditions (i) the burden of these problems at the start and end of TB treatment and (ii) whether referral mechanisms for further care were functional. There were 603 patients registered with drug-susceptible TB who started TB treatment: 84% were symptomatic, 14% had diabetes, 14% had high blood pressure, 19% smoked cigarettes, 10% drank excess alcohol and in 45% the 6 min walking test (6MWT) was abnormal. Five patients were identified with mental health disorders. There were 586 (97%) patients who successfully completed TB treatment six months later. Of these, 18% were still symptomatic, 12% had diabetes (the remainder with diabetes failed to complete treatment), 5% had high blood pressure, 5% smoked cigarettes, 1% drank excess alcohol and 25% had an abnormal 6MWT. Referral mechanisms for the care of comorbidities and determinants worked well except for mental health and pulmonary rehabilitation for disability. There is need for more programmatic-related studies in other countries to build the evidence base for care of TB-related conditions and disability.
format Online
Article
Text
id pubmed-10383887
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-103838872023-07-30 Managing Comorbidities, Determinants and Disability at Start and End of TB Treatment under Routine Program Conditions in China Liu, Yuhong Lin, Yan Sun, Yuxian Thekkur, Pruthu Cheng, Changhao Li, Yuecui Shi, Yunzhen Jiang, Jun Liao, Jiong Nie, Chuangui Sun, Wenyan Liang, Chengyuan Zhang, Xiaojuan Liu, Sang Ma, Yan Berger, Selma Dar Satyanarayana, Srinath Kumar, Ajay M. V. Khogali, Mohammed Zachariah, Rony Golub, Jonathan E. Li, Liang Harries, Anthony D. Trop Med Infect Dis Article Many patients with tuberculosis (TB) have comorbidities, risk determinants and disability that co-exist at diagnosis, during and after TB treatment. We conducted an observational cohort study in 11 health facilities in China to assess under routine program conditions (i) the burden of these problems at the start and end of TB treatment and (ii) whether referral mechanisms for further care were functional. There were 603 patients registered with drug-susceptible TB who started TB treatment: 84% were symptomatic, 14% had diabetes, 14% had high blood pressure, 19% smoked cigarettes, 10% drank excess alcohol and in 45% the 6 min walking test (6MWT) was abnormal. Five patients were identified with mental health disorders. There were 586 (97%) patients who successfully completed TB treatment six months later. Of these, 18% were still symptomatic, 12% had diabetes (the remainder with diabetes failed to complete treatment), 5% had high blood pressure, 5% smoked cigarettes, 1% drank excess alcohol and 25% had an abnormal 6MWT. Referral mechanisms for the care of comorbidities and determinants worked well except for mental health and pulmonary rehabilitation for disability. There is need for more programmatic-related studies in other countries to build the evidence base for care of TB-related conditions and disability. MDPI 2023-06-26 /pmc/articles/PMC10383887/ /pubmed/37505637 http://dx.doi.org/10.3390/tropicalmed8070341 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Liu, Yuhong
Lin, Yan
Sun, Yuxian
Thekkur, Pruthu
Cheng, Changhao
Li, Yuecui
Shi, Yunzhen
Jiang, Jun
Liao, Jiong
Nie, Chuangui
Sun, Wenyan
Liang, Chengyuan
Zhang, Xiaojuan
Liu, Sang
Ma, Yan
Berger, Selma Dar
Satyanarayana, Srinath
Kumar, Ajay M. V.
Khogali, Mohammed
Zachariah, Rony
Golub, Jonathan E.
Li, Liang
Harries, Anthony D.
Managing Comorbidities, Determinants and Disability at Start and End of TB Treatment under Routine Program Conditions in China
title Managing Comorbidities, Determinants and Disability at Start and End of TB Treatment under Routine Program Conditions in China
title_full Managing Comorbidities, Determinants and Disability at Start and End of TB Treatment under Routine Program Conditions in China
title_fullStr Managing Comorbidities, Determinants and Disability at Start and End of TB Treatment under Routine Program Conditions in China
title_full_unstemmed Managing Comorbidities, Determinants and Disability at Start and End of TB Treatment under Routine Program Conditions in China
title_short Managing Comorbidities, Determinants and Disability at Start and End of TB Treatment under Routine Program Conditions in China
title_sort managing comorbidities, determinants and disability at start and end of tb treatment under routine program conditions in china
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10383887/
https://www.ncbi.nlm.nih.gov/pubmed/37505637
http://dx.doi.org/10.3390/tropicalmed8070341
work_keys_str_mv AT liuyuhong managingcomorbiditiesdeterminantsanddisabilityatstartandendoftbtreatmentunderroutineprogramconditionsinchina
AT linyan managingcomorbiditiesdeterminantsanddisabilityatstartandendoftbtreatmentunderroutineprogramconditionsinchina
AT sunyuxian managingcomorbiditiesdeterminantsanddisabilityatstartandendoftbtreatmentunderroutineprogramconditionsinchina
AT thekkurpruthu managingcomorbiditiesdeterminantsanddisabilityatstartandendoftbtreatmentunderroutineprogramconditionsinchina
AT chengchanghao managingcomorbiditiesdeterminantsanddisabilityatstartandendoftbtreatmentunderroutineprogramconditionsinchina
AT liyuecui managingcomorbiditiesdeterminantsanddisabilityatstartandendoftbtreatmentunderroutineprogramconditionsinchina
AT shiyunzhen managingcomorbiditiesdeterminantsanddisabilityatstartandendoftbtreatmentunderroutineprogramconditionsinchina
AT jiangjun managingcomorbiditiesdeterminantsanddisabilityatstartandendoftbtreatmentunderroutineprogramconditionsinchina
AT liaojiong managingcomorbiditiesdeterminantsanddisabilityatstartandendoftbtreatmentunderroutineprogramconditionsinchina
AT niechuangui managingcomorbiditiesdeterminantsanddisabilityatstartandendoftbtreatmentunderroutineprogramconditionsinchina
AT sunwenyan managingcomorbiditiesdeterminantsanddisabilityatstartandendoftbtreatmentunderroutineprogramconditionsinchina
AT liangchengyuan managingcomorbiditiesdeterminantsanddisabilityatstartandendoftbtreatmentunderroutineprogramconditionsinchina
AT zhangxiaojuan managingcomorbiditiesdeterminantsanddisabilityatstartandendoftbtreatmentunderroutineprogramconditionsinchina
AT liusang managingcomorbiditiesdeterminantsanddisabilityatstartandendoftbtreatmentunderroutineprogramconditionsinchina
AT mayan managingcomorbiditiesdeterminantsanddisabilityatstartandendoftbtreatmentunderroutineprogramconditionsinchina
AT bergerselmadar managingcomorbiditiesdeterminantsanddisabilityatstartandendoftbtreatmentunderroutineprogramconditionsinchina
AT satyanarayanasrinath managingcomorbiditiesdeterminantsanddisabilityatstartandendoftbtreatmentunderroutineprogramconditionsinchina
AT kumarajaymv managingcomorbiditiesdeterminantsanddisabilityatstartandendoftbtreatmentunderroutineprogramconditionsinchina
AT khogalimohammed managingcomorbiditiesdeterminantsanddisabilityatstartandendoftbtreatmentunderroutineprogramconditionsinchina
AT zachariahrony managingcomorbiditiesdeterminantsanddisabilityatstartandendoftbtreatmentunderroutineprogramconditionsinchina
AT golubjonathane managingcomorbiditiesdeterminantsanddisabilityatstartandendoftbtreatmentunderroutineprogramconditionsinchina
AT liliang managingcomorbiditiesdeterminantsanddisabilityatstartandendoftbtreatmentunderroutineprogramconditionsinchina
AT harriesanthonyd managingcomorbiditiesdeterminantsanddisabilityatstartandendoftbtreatmentunderroutineprogramconditionsinchina