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Calprotectin, Biomarker of Depression in Patients with Inflammatory Bowel Disease?

Background and Objectives: Calprotectin is a marker for intestinal inflammation. Recent research suggests a link between inflammation and depression. This study assessed the association between the levels of calprotectin in patients from South-Eastern Europe and the severity of depression, anxiety,...

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Autores principales: Iordache, Miorita Melina, Belu, Anca Mihaela, Vlad, Sabina E., Aivaz, Kamer Ainur, Dumitru, Andrei, Tocia, Cristina, Dumitru, Eugen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10383955/
https://www.ncbi.nlm.nih.gov/pubmed/37512053
http://dx.doi.org/10.3390/medicina59071240
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author Iordache, Miorita Melina
Belu, Anca Mihaela
Vlad, Sabina E.
Aivaz, Kamer Ainur
Dumitru, Andrei
Tocia, Cristina
Dumitru, Eugen
author_facet Iordache, Miorita Melina
Belu, Anca Mihaela
Vlad, Sabina E.
Aivaz, Kamer Ainur
Dumitru, Andrei
Tocia, Cristina
Dumitru, Eugen
author_sort Iordache, Miorita Melina
collection PubMed
description Background and Objectives: Calprotectin is a marker for intestinal inflammation. Recent research suggests a link between inflammation and depression. This study assessed the association between the levels of calprotectin in patients from South-Eastern Europe and the severity of depression, anxiety, and quality of life. Materials and Methods: This cross-sectional study included 30 confirmed patients with Crohn’s disease (CD) and ulcerative colitis (UC) who were assessed using clinical interviews for determining the severities of mental disorders (i.e., depression severity—PHQ-9, anxiety—GAD-7) and the quality of life (EQ-5D). Stool samples were collected from all participants for measuring their levels of calprotectin. Results: The level of calprotectin is correlated with PHQ-9 (ρ = 0.416, p = 0.022) and EQ-5D (ρ = −0.304, p = 0.033) but not with GAD 7 (ρ = 0.059, p = 0.379). Calprotectin levels in patients with mild, moderate, and moderately severe depression were significantly higher than in patients with minimal depression (198 µg/g vs. 66,9 µg/g, p = 0.04). Calprotectin level was corelated with the following depressive symptoms: autolytic ideation (ρ = 0.557, p = 0.001), fatigue (ρ = 0.514, p = 0.002), slow movement (ρ = 0.490, p = 0.003), and sleep disorders (ρ = 0.403, p = 0.014). Calprotectin was an independent predictor of depression with an odds ratio of 1.01 (95%: 1.002–1.03, p < 0.01). An ROC analysis showed that a level of calprotectin of 131 µg/g or higher has a sensitivity of 82%, a specificity of 61%, and an accuracy of 70% for predicting depression. In this study, no significant correlations were found between calprotectin level and anxiety. Conclusions: Calprotectin levels are associated with the severity of depression, and checking for a calprotectin level of 131 µg/g or higher may be a potential accessible screening test for depression in patients with inflammatory bowel disease.
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spelling pubmed-103839552023-07-30 Calprotectin, Biomarker of Depression in Patients with Inflammatory Bowel Disease? Iordache, Miorita Melina Belu, Anca Mihaela Vlad, Sabina E. Aivaz, Kamer Ainur Dumitru, Andrei Tocia, Cristina Dumitru, Eugen Medicina (Kaunas) Article Background and Objectives: Calprotectin is a marker for intestinal inflammation. Recent research suggests a link between inflammation and depression. This study assessed the association between the levels of calprotectin in patients from South-Eastern Europe and the severity of depression, anxiety, and quality of life. Materials and Methods: This cross-sectional study included 30 confirmed patients with Crohn’s disease (CD) and ulcerative colitis (UC) who were assessed using clinical interviews for determining the severities of mental disorders (i.e., depression severity—PHQ-9, anxiety—GAD-7) and the quality of life (EQ-5D). Stool samples were collected from all participants for measuring their levels of calprotectin. Results: The level of calprotectin is correlated with PHQ-9 (ρ = 0.416, p = 0.022) and EQ-5D (ρ = −0.304, p = 0.033) but not with GAD 7 (ρ = 0.059, p = 0.379). Calprotectin levels in patients with mild, moderate, and moderately severe depression were significantly higher than in patients with minimal depression (198 µg/g vs. 66,9 µg/g, p = 0.04). Calprotectin level was corelated with the following depressive symptoms: autolytic ideation (ρ = 0.557, p = 0.001), fatigue (ρ = 0.514, p = 0.002), slow movement (ρ = 0.490, p = 0.003), and sleep disorders (ρ = 0.403, p = 0.014). Calprotectin was an independent predictor of depression with an odds ratio of 1.01 (95%: 1.002–1.03, p < 0.01). An ROC analysis showed that a level of calprotectin of 131 µg/g or higher has a sensitivity of 82%, a specificity of 61%, and an accuracy of 70% for predicting depression. In this study, no significant correlations were found between calprotectin level and anxiety. Conclusions: Calprotectin levels are associated with the severity of depression, and checking for a calprotectin level of 131 µg/g or higher may be a potential accessible screening test for depression in patients with inflammatory bowel disease. MDPI 2023-07-03 /pmc/articles/PMC10383955/ /pubmed/37512053 http://dx.doi.org/10.3390/medicina59071240 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Iordache, Miorita Melina
Belu, Anca Mihaela
Vlad, Sabina E.
Aivaz, Kamer Ainur
Dumitru, Andrei
Tocia, Cristina
Dumitru, Eugen
Calprotectin, Biomarker of Depression in Patients with Inflammatory Bowel Disease?
title Calprotectin, Biomarker of Depression in Patients with Inflammatory Bowel Disease?
title_full Calprotectin, Biomarker of Depression in Patients with Inflammatory Bowel Disease?
title_fullStr Calprotectin, Biomarker of Depression in Patients with Inflammatory Bowel Disease?
title_full_unstemmed Calprotectin, Biomarker of Depression in Patients with Inflammatory Bowel Disease?
title_short Calprotectin, Biomarker of Depression in Patients with Inflammatory Bowel Disease?
title_sort calprotectin, biomarker of depression in patients with inflammatory bowel disease?
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10383955/
https://www.ncbi.nlm.nih.gov/pubmed/37512053
http://dx.doi.org/10.3390/medicina59071240
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