m-Terphenylamines, Acting as Selective COX-1 Inhibitors, Block Microglia Inflammatory Response and Exert Neuroprotective Activity

Inhibition of cyclooxygenase-2 (COX-2) has been extensively studied as an approach to reduce proinflammatory markers in acute brain diseases, but the anti-neuroinflammatory role of cyclooxygenase-1 (COX-1) inhibition has been rather neglected. We report that m-terphenylamine derivatives are selectiv...

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Detalles Bibliográficos
Autores principales: Rocchi, Damiano, González, Juan F., Martín-Cámara, Olmo, Perrone, Maria Grazia, Miciaccia, Morena, Scilimati, Antonio, Decouty-Pérez, Celine, Parada, Esther, Egea, Javier, Menéndez, J. Carlos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10384011/
https://www.ncbi.nlm.nih.gov/pubmed/37513247
http://dx.doi.org/10.3390/molecules28145374

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10384011/
https://www.ncbi.nlm.nih.gov/pubmed/37513247
http://dx.doi.org/10.3390/molecules28145374

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