Modeling and Simulation as a Tool to Assess Voriconazole Exposure in the Central Nervous System

Voriconazole is a triazole antifungal used empirically for the treatment of complicated meningitis associated with Cryptococcus neoformans. Biopsy studies show that the drug exhibits adequate brain penetration although levels of cerebral spinal fluid (CSF) are highly variable. Considering that CSF i...

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Detalles Bibliográficos
Autores principales: Staudt, Keli Jaqueline, Dias, Bruna Bernar, Alves, Izabel Almeida, Lelièvre, Bénédicte, Bouchara, Jean-Philippe, de Araújo, Bibiana Verlindo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10384042/
https://www.ncbi.nlm.nih.gov/pubmed/37513968
http://dx.doi.org/10.3390/pharmaceutics15071781

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