Cargando…

Polypropylene-Based Polymer Locking Ligation System Manufacturing by the Ultrasonic Micromolding Process

In recent years, there has been a growing demand for biocompatible medical devices on the microscale. However, the manufacturing of certain microfeatures has posed a significant challenge. To address this limitation, a new process called ultrasonic injection molding or ultrasonic molding (USM) has e...

Descripción completa

Detalles Bibliográficos
Autores principales: Elías-Grajeda, Alex, Vázquez-Lepe, Elisa, Siller, Héctor R., Perales-Martínez, Imperio Anel, Reséndiz-Hernández, Emiliano, Ramírez-Herrera, Claudia Angélica, Olvera-Trejo, Daniel, Martínez-Romero, Oscar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10384151/
https://www.ncbi.nlm.nih.gov/pubmed/37514439
http://dx.doi.org/10.3390/polym15143049
_version_ 1785081086833852416
author Elías-Grajeda, Alex
Vázquez-Lepe, Elisa
Siller, Héctor R.
Perales-Martínez, Imperio Anel
Reséndiz-Hernández, Emiliano
Ramírez-Herrera, Claudia Angélica
Olvera-Trejo, Daniel
Martínez-Romero, Oscar
author_facet Elías-Grajeda, Alex
Vázquez-Lepe, Elisa
Siller, Héctor R.
Perales-Martínez, Imperio Anel
Reséndiz-Hernández, Emiliano
Ramírez-Herrera, Claudia Angélica
Olvera-Trejo, Daniel
Martínez-Romero, Oscar
author_sort Elías-Grajeda, Alex
collection PubMed
description In recent years, there has been a growing demand for biocompatible medical devices on the microscale. However, the manufacturing of certain microfeatures has posed a significant challenge. To address this limitation, a new process called ultrasonic injection molding or ultrasonic molding (USM) has emerged as a potential solution. In this study, we focused on the production of a specific microdevice known as Hem-O-Lok, which is designed for ligation and tissue repair during laparoscopic surgery. Utilizing USM technology, we successfully manufactured the microdevice using a nonabsorbable biopolymer that offers the necessary flexibility for easy handling and use. To ensure high-quality microdevices, we extensively investigated various processing parameters such as vibration amplitude, temperature, and injection velocity. Through careful experimentation, we determined that the microdevice achieved optimal quality when manufactured under conditions of maximum vibrational amplitude and temperatures of 50 and 60 °C. This conclusion was supported by measurements of critical microfeatures. Additionally, our materials characterization efforts revealed the presence of a carbonyl (C=O) group resulting from the thermo-oxidation of air in the plasticizing chamber. This finding contributes to the enhanced thermal stability of the microdevices within a temperature range of 429–437 °C.
format Online
Article
Text
id pubmed-10384151
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-103841512023-07-30 Polypropylene-Based Polymer Locking Ligation System Manufacturing by the Ultrasonic Micromolding Process Elías-Grajeda, Alex Vázquez-Lepe, Elisa Siller, Héctor R. Perales-Martínez, Imperio Anel Reséndiz-Hernández, Emiliano Ramírez-Herrera, Claudia Angélica Olvera-Trejo, Daniel Martínez-Romero, Oscar Polymers (Basel) Article In recent years, there has been a growing demand for biocompatible medical devices on the microscale. However, the manufacturing of certain microfeatures has posed a significant challenge. To address this limitation, a new process called ultrasonic injection molding or ultrasonic molding (USM) has emerged as a potential solution. In this study, we focused on the production of a specific microdevice known as Hem-O-Lok, which is designed for ligation and tissue repair during laparoscopic surgery. Utilizing USM technology, we successfully manufactured the microdevice using a nonabsorbable biopolymer that offers the necessary flexibility for easy handling and use. To ensure high-quality microdevices, we extensively investigated various processing parameters such as vibration amplitude, temperature, and injection velocity. Through careful experimentation, we determined that the microdevice achieved optimal quality when manufactured under conditions of maximum vibrational amplitude and temperatures of 50 and 60 °C. This conclusion was supported by measurements of critical microfeatures. Additionally, our materials characterization efforts revealed the presence of a carbonyl (C=O) group resulting from the thermo-oxidation of air in the plasticizing chamber. This finding contributes to the enhanced thermal stability of the microdevices within a temperature range of 429–437 °C. MDPI 2023-07-15 /pmc/articles/PMC10384151/ /pubmed/37514439 http://dx.doi.org/10.3390/polym15143049 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Elías-Grajeda, Alex
Vázquez-Lepe, Elisa
Siller, Héctor R.
Perales-Martínez, Imperio Anel
Reséndiz-Hernández, Emiliano
Ramírez-Herrera, Claudia Angélica
Olvera-Trejo, Daniel
Martínez-Romero, Oscar
Polypropylene-Based Polymer Locking Ligation System Manufacturing by the Ultrasonic Micromolding Process
title Polypropylene-Based Polymer Locking Ligation System Manufacturing by the Ultrasonic Micromolding Process
title_full Polypropylene-Based Polymer Locking Ligation System Manufacturing by the Ultrasonic Micromolding Process
title_fullStr Polypropylene-Based Polymer Locking Ligation System Manufacturing by the Ultrasonic Micromolding Process
title_full_unstemmed Polypropylene-Based Polymer Locking Ligation System Manufacturing by the Ultrasonic Micromolding Process
title_short Polypropylene-Based Polymer Locking Ligation System Manufacturing by the Ultrasonic Micromolding Process
title_sort polypropylene-based polymer locking ligation system manufacturing by the ultrasonic micromolding process
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10384151/
https://www.ncbi.nlm.nih.gov/pubmed/37514439
http://dx.doi.org/10.3390/polym15143049
work_keys_str_mv AT eliasgrajedaalex polypropylenebasedpolymerlockingligationsystemmanufacturingbytheultrasonicmicromoldingprocess
AT vazquezlepeelisa polypropylenebasedpolymerlockingligationsystemmanufacturingbytheultrasonicmicromoldingprocess
AT sillerhectorr polypropylenebasedpolymerlockingligationsystemmanufacturingbytheultrasonicmicromoldingprocess
AT peralesmartinezimperioanel polypropylenebasedpolymerlockingligationsystemmanufacturingbytheultrasonicmicromoldingprocess
AT resendizhernandezemiliano polypropylenebasedpolymerlockingligationsystemmanufacturingbytheultrasonicmicromoldingprocess
AT ramirezherreraclaudiaangelica polypropylenebasedpolymerlockingligationsystemmanufacturingbytheultrasonicmicromoldingprocess
AT olveratrejodaniel polypropylenebasedpolymerlockingligationsystemmanufacturingbytheultrasonicmicromoldingprocess
AT martinezromerooscar polypropylenebasedpolymerlockingligationsystemmanufacturingbytheultrasonicmicromoldingprocess