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Polypropylene-Based Polymer Locking Ligation System Manufacturing by the Ultrasonic Micromolding Process
In recent years, there has been a growing demand for biocompatible medical devices on the microscale. However, the manufacturing of certain microfeatures has posed a significant challenge. To address this limitation, a new process called ultrasonic injection molding or ultrasonic molding (USM) has e...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10384151/ https://www.ncbi.nlm.nih.gov/pubmed/37514439 http://dx.doi.org/10.3390/polym15143049 |
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author | Elías-Grajeda, Alex Vázquez-Lepe, Elisa Siller, Héctor R. Perales-Martínez, Imperio Anel Reséndiz-Hernández, Emiliano Ramírez-Herrera, Claudia Angélica Olvera-Trejo, Daniel Martínez-Romero, Oscar |
author_facet | Elías-Grajeda, Alex Vázquez-Lepe, Elisa Siller, Héctor R. Perales-Martínez, Imperio Anel Reséndiz-Hernández, Emiliano Ramírez-Herrera, Claudia Angélica Olvera-Trejo, Daniel Martínez-Romero, Oscar |
author_sort | Elías-Grajeda, Alex |
collection | PubMed |
description | In recent years, there has been a growing demand for biocompatible medical devices on the microscale. However, the manufacturing of certain microfeatures has posed a significant challenge. To address this limitation, a new process called ultrasonic injection molding or ultrasonic molding (USM) has emerged as a potential solution. In this study, we focused on the production of a specific microdevice known as Hem-O-Lok, which is designed for ligation and tissue repair during laparoscopic surgery. Utilizing USM technology, we successfully manufactured the microdevice using a nonabsorbable biopolymer that offers the necessary flexibility for easy handling and use. To ensure high-quality microdevices, we extensively investigated various processing parameters such as vibration amplitude, temperature, and injection velocity. Through careful experimentation, we determined that the microdevice achieved optimal quality when manufactured under conditions of maximum vibrational amplitude and temperatures of 50 and 60 °C. This conclusion was supported by measurements of critical microfeatures. Additionally, our materials characterization efforts revealed the presence of a carbonyl (C=O) group resulting from the thermo-oxidation of air in the plasticizing chamber. This finding contributes to the enhanced thermal stability of the microdevices within a temperature range of 429–437 °C. |
format | Online Article Text |
id | pubmed-10384151 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-103841512023-07-30 Polypropylene-Based Polymer Locking Ligation System Manufacturing by the Ultrasonic Micromolding Process Elías-Grajeda, Alex Vázquez-Lepe, Elisa Siller, Héctor R. Perales-Martínez, Imperio Anel Reséndiz-Hernández, Emiliano Ramírez-Herrera, Claudia Angélica Olvera-Trejo, Daniel Martínez-Romero, Oscar Polymers (Basel) Article In recent years, there has been a growing demand for biocompatible medical devices on the microscale. However, the manufacturing of certain microfeatures has posed a significant challenge. To address this limitation, a new process called ultrasonic injection molding or ultrasonic molding (USM) has emerged as a potential solution. In this study, we focused on the production of a specific microdevice known as Hem-O-Lok, which is designed for ligation and tissue repair during laparoscopic surgery. Utilizing USM technology, we successfully manufactured the microdevice using a nonabsorbable biopolymer that offers the necessary flexibility for easy handling and use. To ensure high-quality microdevices, we extensively investigated various processing parameters such as vibration amplitude, temperature, and injection velocity. Through careful experimentation, we determined that the microdevice achieved optimal quality when manufactured under conditions of maximum vibrational amplitude and temperatures of 50 and 60 °C. This conclusion was supported by measurements of critical microfeatures. Additionally, our materials characterization efforts revealed the presence of a carbonyl (C=O) group resulting from the thermo-oxidation of air in the plasticizing chamber. This finding contributes to the enhanced thermal stability of the microdevices within a temperature range of 429–437 °C. MDPI 2023-07-15 /pmc/articles/PMC10384151/ /pubmed/37514439 http://dx.doi.org/10.3390/polym15143049 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Elías-Grajeda, Alex Vázquez-Lepe, Elisa Siller, Héctor R. Perales-Martínez, Imperio Anel Reséndiz-Hernández, Emiliano Ramírez-Herrera, Claudia Angélica Olvera-Trejo, Daniel Martínez-Romero, Oscar Polypropylene-Based Polymer Locking Ligation System Manufacturing by the Ultrasonic Micromolding Process |
title | Polypropylene-Based Polymer Locking Ligation System Manufacturing by the Ultrasonic Micromolding Process |
title_full | Polypropylene-Based Polymer Locking Ligation System Manufacturing by the Ultrasonic Micromolding Process |
title_fullStr | Polypropylene-Based Polymer Locking Ligation System Manufacturing by the Ultrasonic Micromolding Process |
title_full_unstemmed | Polypropylene-Based Polymer Locking Ligation System Manufacturing by the Ultrasonic Micromolding Process |
title_short | Polypropylene-Based Polymer Locking Ligation System Manufacturing by the Ultrasonic Micromolding Process |
title_sort | polypropylene-based polymer locking ligation system manufacturing by the ultrasonic micromolding process |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10384151/ https://www.ncbi.nlm.nih.gov/pubmed/37514439 http://dx.doi.org/10.3390/polym15143049 |
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