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3D-Printed Microfluidic One-Way Valves and Pumps

New microfluidic lab-on-a-chip capabilities are enabled by broadening the toolkit of devices that can be created using microfabrication processes. For example, complex geometries made possible by 3D printing can be used to approach microfluidic design and application in new or enhanced ways. In this...

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Autores principales: Hinnen, Hunter, Viglione, Matthew, Munro, Troy R., Woolley, Adam T., Nordin, Gregory P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10384158/
https://www.ncbi.nlm.nih.gov/pubmed/37512597
http://dx.doi.org/10.3390/mi14071286
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author Hinnen, Hunter
Viglione, Matthew
Munro, Troy R.
Woolley, Adam T.
Nordin, Gregory P.
author_facet Hinnen, Hunter
Viglione, Matthew
Munro, Troy R.
Woolley, Adam T.
Nordin, Gregory P.
author_sort Hinnen, Hunter
collection PubMed
description New microfluidic lab-on-a-chip capabilities are enabled by broadening the toolkit of devices that can be created using microfabrication processes. For example, complex geometries made possible by 3D printing can be used to approach microfluidic design and application in new or enhanced ways. In this paper, we demonstrate three distinct designs for microfluidic one-way (check) valves that can be fabricated using digital light processing stereolithography (DLP-SLA) with a poly(ethylene glycol) diacrylate (PEGDA) resin, each with an internal volume of 5–10 nL. By mapping flow rate to pressure in both the forward and reverse directions, we compare the different designs and their operating characteristics. We also demonstrate pumps for each one-way valve design comprised of two one-way valves with a membrane valve displacement chamber between them. An advantage of such pumps is that they require a single pneumatic input instead of three as for conventional 3D-printed pumps. We also characterize the achievable flow rate as a function of the pneumatic control signal period. We show that such pumps can be used to create a single-stage diffusion mixer with significantly reduced pneumatic drive complexity.
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spelling pubmed-103841582023-07-30 3D-Printed Microfluidic One-Way Valves and Pumps Hinnen, Hunter Viglione, Matthew Munro, Troy R. Woolley, Adam T. Nordin, Gregory P. Micromachines (Basel) Article New microfluidic lab-on-a-chip capabilities are enabled by broadening the toolkit of devices that can be created using microfabrication processes. For example, complex geometries made possible by 3D printing can be used to approach microfluidic design and application in new or enhanced ways. In this paper, we demonstrate three distinct designs for microfluidic one-way (check) valves that can be fabricated using digital light processing stereolithography (DLP-SLA) with a poly(ethylene glycol) diacrylate (PEGDA) resin, each with an internal volume of 5–10 nL. By mapping flow rate to pressure in both the forward and reverse directions, we compare the different designs and their operating characteristics. We also demonstrate pumps for each one-way valve design comprised of two one-way valves with a membrane valve displacement chamber between them. An advantage of such pumps is that they require a single pneumatic input instead of three as for conventional 3D-printed pumps. We also characterize the achievable flow rate as a function of the pneumatic control signal period. We show that such pumps can be used to create a single-stage diffusion mixer with significantly reduced pneumatic drive complexity. MDPI 2023-06-23 /pmc/articles/PMC10384158/ /pubmed/37512597 http://dx.doi.org/10.3390/mi14071286 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Hinnen, Hunter
Viglione, Matthew
Munro, Troy R.
Woolley, Adam T.
Nordin, Gregory P.
3D-Printed Microfluidic One-Way Valves and Pumps
title 3D-Printed Microfluidic One-Way Valves and Pumps
title_full 3D-Printed Microfluidic One-Way Valves and Pumps
title_fullStr 3D-Printed Microfluidic One-Way Valves and Pumps
title_full_unstemmed 3D-Printed Microfluidic One-Way Valves and Pumps
title_short 3D-Printed Microfluidic One-Way Valves and Pumps
title_sort 3d-printed microfluidic one-way valves and pumps
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10384158/
https://www.ncbi.nlm.nih.gov/pubmed/37512597
http://dx.doi.org/10.3390/mi14071286
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