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Discharge Outcomes of Severely Sick Patients Hospitalized with Multidrug-Resistant Tuberculosis, Comorbidities, and Serious Adverse Events in Kyrgyz Republic, 2020–2022

Patients with multidrug-resistant tuberculosis (MDR-TB) who have comorbidities, complications, and experience serious adverse events (SAEs) are at substantial risk of having unfavorable hospital outcomes. We assessed characteristics and discharge outcomes of 138 MDR-TB patients hospitalized in the N...

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Autores principales: Alumkulova, Gulzat, Hazoyan, Anna, Zhdanova, Elena, Kuznetsova, Yuliia, Tripathy, Jaya Prasad, Sargsyan, Aelita, Goncharova, Olga, Kadyrov, Meder, Istamov, Kylychbek, Ortuño-Gutiérrez, Nimer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10384159/
https://www.ncbi.nlm.nih.gov/pubmed/37505634
http://dx.doi.org/10.3390/tropicalmed8070338
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author Alumkulova, Gulzat
Hazoyan, Anna
Zhdanova, Elena
Kuznetsova, Yuliia
Tripathy, Jaya Prasad
Sargsyan, Aelita
Goncharova, Olga
Kadyrov, Meder
Istamov, Kylychbek
Ortuño-Gutiérrez, Nimer
author_facet Alumkulova, Gulzat
Hazoyan, Anna
Zhdanova, Elena
Kuznetsova, Yuliia
Tripathy, Jaya Prasad
Sargsyan, Aelita
Goncharova, Olga
Kadyrov, Meder
Istamov, Kylychbek
Ortuño-Gutiérrez, Nimer
author_sort Alumkulova, Gulzat
collection PubMed
description Patients with multidrug-resistant tuberculosis (MDR-TB) who have comorbidities, complications, and experience serious adverse events (SAEs) are at substantial risk of having unfavorable hospital outcomes. We assessed characteristics and discharge outcomes of 138 MDR-TB patients hospitalized in the National Referral Center of Bishkek, Kyrgyz Republic, from January 2020 to August 2022. The main clinical characteristics included pulmonary complications (23%), malnutrition (33%), severe anemia (17%), diabetes mellitus (13%), viral hepatitis B and C (5%), and HIV infection (3%). Of those patients, 95% were successfully managed and discharged from hospital. Seven patients had unfavorable discharge outcomes (three patients died and four had a worsened clinical condition). Comorbidities (diabetes, and/or HIV), severe anemia, pulmonary complications, cardiovascular disorders, alcohol abuse, and SAEs were associated with unfavorable discharge outcomes. Sixty-five percent of the patients had SAEs, with electrolyte imbalance (25%), gastrointestinal disease (18%), hepatotoxicity (16%), and anemia (14%) being the most frequent. Successful resolution occurred in 91% of patients with SAEs. In summary, our study documented that sick patients who were hospitalized with MDR-TB were well managed and had good hospital discharge outcomes, despite the fact that they had comorbidities, complications, and SAEs. This information should assist in the referral and management of such patients in the future.
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spelling pubmed-103841592023-07-30 Discharge Outcomes of Severely Sick Patients Hospitalized with Multidrug-Resistant Tuberculosis, Comorbidities, and Serious Adverse Events in Kyrgyz Republic, 2020–2022 Alumkulova, Gulzat Hazoyan, Anna Zhdanova, Elena Kuznetsova, Yuliia Tripathy, Jaya Prasad Sargsyan, Aelita Goncharova, Olga Kadyrov, Meder Istamov, Kylychbek Ortuño-Gutiérrez, Nimer Trop Med Infect Dis Article Patients with multidrug-resistant tuberculosis (MDR-TB) who have comorbidities, complications, and experience serious adverse events (SAEs) are at substantial risk of having unfavorable hospital outcomes. We assessed characteristics and discharge outcomes of 138 MDR-TB patients hospitalized in the National Referral Center of Bishkek, Kyrgyz Republic, from January 2020 to August 2022. The main clinical characteristics included pulmonary complications (23%), malnutrition (33%), severe anemia (17%), diabetes mellitus (13%), viral hepatitis B and C (5%), and HIV infection (3%). Of those patients, 95% were successfully managed and discharged from hospital. Seven patients had unfavorable discharge outcomes (three patients died and four had a worsened clinical condition). Comorbidities (diabetes, and/or HIV), severe anemia, pulmonary complications, cardiovascular disorders, alcohol abuse, and SAEs were associated with unfavorable discharge outcomes. Sixty-five percent of the patients had SAEs, with electrolyte imbalance (25%), gastrointestinal disease (18%), hepatotoxicity (16%), and anemia (14%) being the most frequent. Successful resolution occurred in 91% of patients with SAEs. In summary, our study documented that sick patients who were hospitalized with MDR-TB were well managed and had good hospital discharge outcomes, despite the fact that they had comorbidities, complications, and SAEs. This information should assist in the referral and management of such patients in the future. MDPI 2023-06-25 /pmc/articles/PMC10384159/ /pubmed/37505634 http://dx.doi.org/10.3390/tropicalmed8070338 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Alumkulova, Gulzat
Hazoyan, Anna
Zhdanova, Elena
Kuznetsova, Yuliia
Tripathy, Jaya Prasad
Sargsyan, Aelita
Goncharova, Olga
Kadyrov, Meder
Istamov, Kylychbek
Ortuño-Gutiérrez, Nimer
Discharge Outcomes of Severely Sick Patients Hospitalized with Multidrug-Resistant Tuberculosis, Comorbidities, and Serious Adverse Events in Kyrgyz Republic, 2020–2022
title Discharge Outcomes of Severely Sick Patients Hospitalized with Multidrug-Resistant Tuberculosis, Comorbidities, and Serious Adverse Events in Kyrgyz Republic, 2020–2022
title_full Discharge Outcomes of Severely Sick Patients Hospitalized with Multidrug-Resistant Tuberculosis, Comorbidities, and Serious Adverse Events in Kyrgyz Republic, 2020–2022
title_fullStr Discharge Outcomes of Severely Sick Patients Hospitalized with Multidrug-Resistant Tuberculosis, Comorbidities, and Serious Adverse Events in Kyrgyz Republic, 2020–2022
title_full_unstemmed Discharge Outcomes of Severely Sick Patients Hospitalized with Multidrug-Resistant Tuberculosis, Comorbidities, and Serious Adverse Events in Kyrgyz Republic, 2020–2022
title_short Discharge Outcomes of Severely Sick Patients Hospitalized with Multidrug-Resistant Tuberculosis, Comorbidities, and Serious Adverse Events in Kyrgyz Republic, 2020–2022
title_sort discharge outcomes of severely sick patients hospitalized with multidrug-resistant tuberculosis, comorbidities, and serious adverse events in kyrgyz republic, 2020–2022
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10384159/
https://www.ncbi.nlm.nih.gov/pubmed/37505634
http://dx.doi.org/10.3390/tropicalmed8070338
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