SARS-CoV-2 Spike Protein Is Capable of Inducing Cell–Cell Fusions Independent from Its Receptor ACE2 and This Activity Can Be Impaired by Furin Inhibitors or a Subset of Monoclonal Antibodies

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which was responsible for the COVID-19 pandemic, efficiently spreads cell-to-cell through mechanisms facilitated by its membrane glycoprotein spike. We established a dual split protein (DSP) assay based on the complementation of GFP and l...

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Detalles Bibliográficos
Autores principales: Reuter, Nina, Chen, Xiaohan, Kropff, Barbara, Peter, Antonia Sophia, Britt, William J., Mach, Michael, Überla, Klaus, Thomas, Marco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10384293/
https://www.ncbi.nlm.nih.gov/pubmed/37515187
http://dx.doi.org/10.3390/v15071500

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