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Effect of E-Vaping on Kidney Health in Mice Consuming a High-Fat Diet

High-fat diet (HFD) consumption and tobacco smoking are risk factors for chronic kidney disease. E-cigarettes have gained significant popularity among younger populations worldwide, especially among overweight individuals. It is unclear whether vaping interacts with HFD consumption to impact renal h...

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Autores principales: Feng, Min, Bai, Xu, Thorpe, Andrew E., Nguyen, Long The, Wang, Meng, Oliver, Brian G., Chou, Angela S. Y., Pollock, Carol A., Saad, Sonia, Chen, Hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10384319/
https://www.ncbi.nlm.nih.gov/pubmed/37513558
http://dx.doi.org/10.3390/nu15143140
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author Feng, Min
Bai, Xu
Thorpe, Andrew E.
Nguyen, Long The
Wang, Meng
Oliver, Brian G.
Chou, Angela S. Y.
Pollock, Carol A.
Saad, Sonia
Chen, Hui
author_facet Feng, Min
Bai, Xu
Thorpe, Andrew E.
Nguyen, Long The
Wang, Meng
Oliver, Brian G.
Chou, Angela S. Y.
Pollock, Carol A.
Saad, Sonia
Chen, Hui
author_sort Feng, Min
collection PubMed
description High-fat diet (HFD) consumption and tobacco smoking are risk factors for chronic kidney disease. E-cigarettes have gained significant popularity among younger populations worldwide, especially among overweight individuals. It is unclear whether vaping interacts with HFD consumption to impact renal health. In this study, Balb/c mice (male, 7 weeks old) were fed a pellet HFD (43% fat, 20 kJ/g) for 16 weeks when exposed to nicotine or nicotine-free e-vapour from weeks 11 to 16. While HFD alone increased collagen Ia and IV depositions, it did not cause significant oxidative stress and inflammatory responses in the kidney itself. On the other hand, e-vapour exposure alone increased oxidative stress and damaged DNA and mitochondrial oxidative phosphorylation complexes without significant impact on fibrotic markers. However, the combination of nicotine e-vapour and HFD increased inflammatory responses, oxidative stress-induced DNA injury, and pro-fibrotic markers, suggesting accelerated development of renal pathology. Nicotine-free e-vapour exposure and HFD consumption suppressed the production of mitochondrial OXPHOS complexes and extracellular matrix protein deposition, which may cause structural instability that can interrupt normal kidney function in the future. In conclusion, our study demonstrated that a HFD combined with e-cigarette vapour exposure, especially when containing nicotine, can increase susceptibility to kidney disease.
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spelling pubmed-103843192023-07-30 Effect of E-Vaping on Kidney Health in Mice Consuming a High-Fat Diet Feng, Min Bai, Xu Thorpe, Andrew E. Nguyen, Long The Wang, Meng Oliver, Brian G. Chou, Angela S. Y. Pollock, Carol A. Saad, Sonia Chen, Hui Nutrients Article High-fat diet (HFD) consumption and tobacco smoking are risk factors for chronic kidney disease. E-cigarettes have gained significant popularity among younger populations worldwide, especially among overweight individuals. It is unclear whether vaping interacts with HFD consumption to impact renal health. In this study, Balb/c mice (male, 7 weeks old) were fed a pellet HFD (43% fat, 20 kJ/g) for 16 weeks when exposed to nicotine or nicotine-free e-vapour from weeks 11 to 16. While HFD alone increased collagen Ia and IV depositions, it did not cause significant oxidative stress and inflammatory responses in the kidney itself. On the other hand, e-vapour exposure alone increased oxidative stress and damaged DNA and mitochondrial oxidative phosphorylation complexes without significant impact on fibrotic markers. However, the combination of nicotine e-vapour and HFD increased inflammatory responses, oxidative stress-induced DNA injury, and pro-fibrotic markers, suggesting accelerated development of renal pathology. Nicotine-free e-vapour exposure and HFD consumption suppressed the production of mitochondrial OXPHOS complexes and extracellular matrix protein deposition, which may cause structural instability that can interrupt normal kidney function in the future. In conclusion, our study demonstrated that a HFD combined with e-cigarette vapour exposure, especially when containing nicotine, can increase susceptibility to kidney disease. MDPI 2023-07-14 /pmc/articles/PMC10384319/ /pubmed/37513558 http://dx.doi.org/10.3390/nu15143140 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Feng, Min
Bai, Xu
Thorpe, Andrew E.
Nguyen, Long The
Wang, Meng
Oliver, Brian G.
Chou, Angela S. Y.
Pollock, Carol A.
Saad, Sonia
Chen, Hui
Effect of E-Vaping on Kidney Health in Mice Consuming a High-Fat Diet
title Effect of E-Vaping on Kidney Health in Mice Consuming a High-Fat Diet
title_full Effect of E-Vaping on Kidney Health in Mice Consuming a High-Fat Diet
title_fullStr Effect of E-Vaping on Kidney Health in Mice Consuming a High-Fat Diet
title_full_unstemmed Effect of E-Vaping on Kidney Health in Mice Consuming a High-Fat Diet
title_short Effect of E-Vaping on Kidney Health in Mice Consuming a High-Fat Diet
title_sort effect of e-vaping on kidney health in mice consuming a high-fat diet
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10384319/
https://www.ncbi.nlm.nih.gov/pubmed/37513558
http://dx.doi.org/10.3390/nu15143140
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