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A Mass Spectrometry Database for Sea Cucumber Triterpene Glycosides
Sea cucumber triterpene glycosides are a class of secondary metabolites that possess distinctive chemical structures and exhibit a variety of biological and pharmacological activities. The application of MS-based approaches for the study of triterpene glycosides allows rapid evaluation of the struct...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10384350/ https://www.ncbi.nlm.nih.gov/pubmed/37512490 http://dx.doi.org/10.3390/metabo13070783 |
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author | Popov, Roman S. Ivanchina, Natalia V. Silchenko, Alexandra S. Avilov, Sergey A. Kalinin, Vladimir I. Malyarenko, Timofey V. Stonik, Valentin A. Dmitrenok, Pavel S. |
author_facet | Popov, Roman S. Ivanchina, Natalia V. Silchenko, Alexandra S. Avilov, Sergey A. Kalinin, Vladimir I. Malyarenko, Timofey V. Stonik, Valentin A. Dmitrenok, Pavel S. |
author_sort | Popov, Roman S. |
collection | PubMed |
description | Sea cucumber triterpene glycosides are a class of secondary metabolites that possess distinctive chemical structures and exhibit a variety of biological and pharmacological activities. The application of MS-based approaches for the study of triterpene glycosides allows rapid evaluation of the structural diversity of metabolites in complex mixtures. However, the identification of the detected triterpene glycosides can be challenging. The objective of this study is to establish the first spectral library containing the mass spectra of sea cucumber triterpene glycosides using ultraperformance liquid chromatography-quadrupole time-of-flight mass spectrometry. The library contains the electrospray ionization tandem mass spectra and retention times of 191 triterpene glycosides previously isolated from 15 sea cucumber species and one starfish at the Laboratory of the Chemistry of Marine Natural Products of the G.B. Elyakov Pacific Institute of Bioorganic Chemistry. In addition, the chromatographic behavior and some structure-related neutral losses in tandem MS are discussed. The obtained data will accelerate the accurate dereplication of known triterpene glycosides and the annotation of novel compounds, as we demonstrated by the processing of LC-MS/MS data of Eupentacta fraudatrix extract. |
format | Online Article Text |
id | pubmed-10384350 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-103843502023-07-30 A Mass Spectrometry Database for Sea Cucumber Triterpene Glycosides Popov, Roman S. Ivanchina, Natalia V. Silchenko, Alexandra S. Avilov, Sergey A. Kalinin, Vladimir I. Malyarenko, Timofey V. Stonik, Valentin A. Dmitrenok, Pavel S. Metabolites Article Sea cucumber triterpene glycosides are a class of secondary metabolites that possess distinctive chemical structures and exhibit a variety of biological and pharmacological activities. The application of MS-based approaches for the study of triterpene glycosides allows rapid evaluation of the structural diversity of metabolites in complex mixtures. However, the identification of the detected triterpene glycosides can be challenging. The objective of this study is to establish the first spectral library containing the mass spectra of sea cucumber triterpene glycosides using ultraperformance liquid chromatography-quadrupole time-of-flight mass spectrometry. The library contains the electrospray ionization tandem mass spectra and retention times of 191 triterpene glycosides previously isolated from 15 sea cucumber species and one starfish at the Laboratory of the Chemistry of Marine Natural Products of the G.B. Elyakov Pacific Institute of Bioorganic Chemistry. In addition, the chromatographic behavior and some structure-related neutral losses in tandem MS are discussed. The obtained data will accelerate the accurate dereplication of known triterpene glycosides and the annotation of novel compounds, as we demonstrated by the processing of LC-MS/MS data of Eupentacta fraudatrix extract. MDPI 2023-06-23 /pmc/articles/PMC10384350/ /pubmed/37512490 http://dx.doi.org/10.3390/metabo13070783 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Popov, Roman S. Ivanchina, Natalia V. Silchenko, Alexandra S. Avilov, Sergey A. Kalinin, Vladimir I. Malyarenko, Timofey V. Stonik, Valentin A. Dmitrenok, Pavel S. A Mass Spectrometry Database for Sea Cucumber Triterpene Glycosides |
title | A Mass Spectrometry Database for Sea Cucumber Triterpene Glycosides |
title_full | A Mass Spectrometry Database for Sea Cucumber Triterpene Glycosides |
title_fullStr | A Mass Spectrometry Database for Sea Cucumber Triterpene Glycosides |
title_full_unstemmed | A Mass Spectrometry Database for Sea Cucumber Triterpene Glycosides |
title_short | A Mass Spectrometry Database for Sea Cucumber Triterpene Glycosides |
title_sort | mass spectrometry database for sea cucumber triterpene glycosides |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10384350/ https://www.ncbi.nlm.nih.gov/pubmed/37512490 http://dx.doi.org/10.3390/metabo13070783 |
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