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A Case of Acquired Aplastic Anemia after Severe Hepatitis- Probably Induced by the Pfizer/BioNTech Vaccine: A Case Report and Review of Literature

Introduction: An important but rare adverse effect of vaccines is their association with autoimmune events, including hepatitis and aplastic anemia (AA). In this paper, we report a case of hepatitis followed by AA that occurred after the COVID-19 vaccine was administered. Case report: This paper foc...

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Autores principales: Kmira, Zahra, Sabrine, Khirallah, Monia, Guermazi, Imen, Akkari, Dorra, Chiba, Rania, Bannour, Neila, Fathallah, Walid, Bouteraa, Monia, Zaier, Yosra, Ben Youssef, Haifa, Regaieg, Abderrahim, Khelif
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10384467/
https://www.ncbi.nlm.nih.gov/pubmed/37515043
http://dx.doi.org/10.3390/vaccines11071228
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author Kmira, Zahra
Sabrine, Khirallah
Monia, Guermazi
Imen, Akkari
Dorra, Chiba
Rania, Bannour
Neila, Fathallah
Walid, Bouteraa
Monia, Zaier
Yosra, Ben Youssef
Haifa, Regaieg
Abderrahim, Khelif
author_facet Kmira, Zahra
Sabrine, Khirallah
Monia, Guermazi
Imen, Akkari
Dorra, Chiba
Rania, Bannour
Neila, Fathallah
Walid, Bouteraa
Monia, Zaier
Yosra, Ben Youssef
Haifa, Regaieg
Abderrahim, Khelif
author_sort Kmira, Zahra
collection PubMed
description Introduction: An important but rare adverse effect of vaccines is their association with autoimmune events, including hepatitis and aplastic anemia (AA). In this paper, we report a case of hepatitis followed by AA that occurred after the COVID-19 vaccine was administered. Case report: This paper focuses on a 30-year-old female who presented with acute hepatitis three weeks after receiving the second dose of the coronavirus Pfizer/BioNTech vaccine. After an extensive diagnostic evaluation was conducted that did not discover a specific cause, the Pfizer/BioNTech vaccine was suspected and the patient was treated with corticosteroids. One week after the onset of a liver disorder, the patient presented with gum bleeding and pancytopenia, and the diagnosis of AA was established via laboratory testing and bone marrow biopsy. After the diagnosis, the patient received immunosuppressive therapy using anti-lymphocyte serum (ATGAM) and CYCLOSPORINE A with progressive improvements in cytopenia. The important issue is whether AA is related to acute hepatitis or the coronavirus vaccine. Conclusion: Clinicians should be aware of the risk of both the possibility of acute hepatitis, AA, or both after receiving the COVID-19 vaccination. It is very hard to distinguish the cause of AA between vaccine- and hepatitis-related AA. Predicting who develops hepatic or myelo-complications after vaccination is difficult.
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spelling pubmed-103844672023-07-30 A Case of Acquired Aplastic Anemia after Severe Hepatitis- Probably Induced by the Pfizer/BioNTech Vaccine: A Case Report and Review of Literature Kmira, Zahra Sabrine, Khirallah Monia, Guermazi Imen, Akkari Dorra, Chiba Rania, Bannour Neila, Fathallah Walid, Bouteraa Monia, Zaier Yosra, Ben Youssef Haifa, Regaieg Abderrahim, Khelif Vaccines (Basel) Case Report Introduction: An important but rare adverse effect of vaccines is their association with autoimmune events, including hepatitis and aplastic anemia (AA). In this paper, we report a case of hepatitis followed by AA that occurred after the COVID-19 vaccine was administered. Case report: This paper focuses on a 30-year-old female who presented with acute hepatitis three weeks after receiving the second dose of the coronavirus Pfizer/BioNTech vaccine. After an extensive diagnostic evaluation was conducted that did not discover a specific cause, the Pfizer/BioNTech vaccine was suspected and the patient was treated with corticosteroids. One week after the onset of a liver disorder, the patient presented with gum bleeding and pancytopenia, and the diagnosis of AA was established via laboratory testing and bone marrow biopsy. After the diagnosis, the patient received immunosuppressive therapy using anti-lymphocyte serum (ATGAM) and CYCLOSPORINE A with progressive improvements in cytopenia. The important issue is whether AA is related to acute hepatitis or the coronavirus vaccine. Conclusion: Clinicians should be aware of the risk of both the possibility of acute hepatitis, AA, or both after receiving the COVID-19 vaccination. It is very hard to distinguish the cause of AA between vaccine- and hepatitis-related AA. Predicting who develops hepatic or myelo-complications after vaccination is difficult. MDPI 2023-07-11 /pmc/articles/PMC10384467/ /pubmed/37515043 http://dx.doi.org/10.3390/vaccines11071228 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Kmira, Zahra
Sabrine, Khirallah
Monia, Guermazi
Imen, Akkari
Dorra, Chiba
Rania, Bannour
Neila, Fathallah
Walid, Bouteraa
Monia, Zaier
Yosra, Ben Youssef
Haifa, Regaieg
Abderrahim, Khelif
A Case of Acquired Aplastic Anemia after Severe Hepatitis- Probably Induced by the Pfizer/BioNTech Vaccine: A Case Report and Review of Literature
title A Case of Acquired Aplastic Anemia after Severe Hepatitis- Probably Induced by the Pfizer/BioNTech Vaccine: A Case Report and Review of Literature
title_full A Case of Acquired Aplastic Anemia after Severe Hepatitis- Probably Induced by the Pfizer/BioNTech Vaccine: A Case Report and Review of Literature
title_fullStr A Case of Acquired Aplastic Anemia after Severe Hepatitis- Probably Induced by the Pfizer/BioNTech Vaccine: A Case Report and Review of Literature
title_full_unstemmed A Case of Acquired Aplastic Anemia after Severe Hepatitis- Probably Induced by the Pfizer/BioNTech Vaccine: A Case Report and Review of Literature
title_short A Case of Acquired Aplastic Anemia after Severe Hepatitis- Probably Induced by the Pfizer/BioNTech Vaccine: A Case Report and Review of Literature
title_sort case of acquired aplastic anemia after severe hepatitis- probably induced by the pfizer/biontech vaccine: a case report and review of literature
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10384467/
https://www.ncbi.nlm.nih.gov/pubmed/37515043
http://dx.doi.org/10.3390/vaccines11071228
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