Serinol-Based Versatile Disulfide-Reducing Reagent †

Here, we report the synthesis of disulfide-reducing agents 2-(dibenzylamino) propane-1,3-dithiol (DPDT) and 2-(dibenzylamino)-2-methylpropane-1,3-dithiol (DMPDT) from serinol and methyl serinol, respectively. DPDT was found to show greater stability than DMPDT. Hence, the effectiveness of DPDT as a...

Descripción completa

Detalles Bibliográficos
Autores principales: Kushwaha, Babita, Mthembu, Sinenhlanhla N., Sharma, Anamika, Albericio, Fernando, de la Torre, Beatriz G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10384529/
https://www.ncbi.nlm.nih.gov/pubmed/37513361
http://dx.doi.org/10.3390/molecules28145489
_version_ 1785081180018704384
author Kushwaha, Babita
Mthembu, Sinenhlanhla N.
Sharma, Anamika
Albericio, Fernando
de la Torre, Beatriz G.
author_facet Kushwaha, Babita
Mthembu, Sinenhlanhla N.
Sharma, Anamika
Albericio, Fernando
de la Torre, Beatriz G.
author_sort Kushwaha, Babita
collection PubMed
description Here, we report the synthesis of disulfide-reducing agents 2-(dibenzylamino) propane-1,3-dithiol (DPDT) and 2-(dibenzylamino)-2-methylpropane-1,3-dithiol (DMPDT) from serinol and methyl serinol, respectively. DPDT was found to show greater stability than DMPDT. Hence, the effectiveness of DPDT as a reducing agent was evaluated in both liquid and solid phases. The reducing capacity of this agent was comparable to that of DTT.
format Online
Article
Text
id pubmed-10384529
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-103845292023-07-30 Serinol-Based Versatile Disulfide-Reducing Reagent † Kushwaha, Babita Mthembu, Sinenhlanhla N. Sharma, Anamika Albericio, Fernando de la Torre, Beatriz G. Molecules Article Here, we report the synthesis of disulfide-reducing agents 2-(dibenzylamino) propane-1,3-dithiol (DPDT) and 2-(dibenzylamino)-2-methylpropane-1,3-dithiol (DMPDT) from serinol and methyl serinol, respectively. DPDT was found to show greater stability than DMPDT. Hence, the effectiveness of DPDT as a reducing agent was evaluated in both liquid and solid phases. The reducing capacity of this agent was comparable to that of DTT. MDPI 2023-07-18 /pmc/articles/PMC10384529/ /pubmed/37513361 http://dx.doi.org/10.3390/molecules28145489 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kushwaha, Babita
Mthembu, Sinenhlanhla N.
Sharma, Anamika
Albericio, Fernando
de la Torre, Beatriz G.
Serinol-Based Versatile Disulfide-Reducing Reagent †
title Serinol-Based Versatile Disulfide-Reducing Reagent †
title_full Serinol-Based Versatile Disulfide-Reducing Reagent †
title_fullStr Serinol-Based Versatile Disulfide-Reducing Reagent †
title_full_unstemmed Serinol-Based Versatile Disulfide-Reducing Reagent †
title_short Serinol-Based Versatile Disulfide-Reducing Reagent †
title_sort serinol-based versatile disulfide-reducing reagent †
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10384529/
https://www.ncbi.nlm.nih.gov/pubmed/37513361
http://dx.doi.org/10.3390/molecules28145489
work_keys_str_mv AT kushwahababita serinolbasedversatiledisulfidereducingreagent
AT mthembusinenhlanhlan serinolbasedversatiledisulfidereducingreagent
AT sharmaanamika serinolbasedversatiledisulfidereducingreagent
AT albericiofernando serinolbasedversatiledisulfidereducingreagent
AT delatorrebeatrizg serinolbasedversatiledisulfidereducingreagent

Ejemplares similares