Cargando…
Begomovirus–Host Interactions: Viral Proteins Orchestrating Intra and Intercellular Transport of Viral DNA While Suppressing Host Defense Mechanisms
Begomoviruses, which belong to the Geminiviridae family, are intracellular parasites transmitted by whiteflies to dicotyledonous plants thatsignificantly damage agronomically relevant crops. These nucleus-replicating DNA viruses move intracellularly from the nucleus to the cytoplasm and then, like o...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10384534/ https://www.ncbi.nlm.nih.gov/pubmed/37515277 http://dx.doi.org/10.3390/v15071593 |
_version_ | 1785081181254975488 |
---|---|
author | Breves, Sâmera S. Silva, Fredy A. Euclydes, Nívea C. Saia, Thainá F. F. Jean-Baptiste, James Andrade Neto, Eugenio R. Fontes, Elizabeth P. B. |
author_facet | Breves, Sâmera S. Silva, Fredy A. Euclydes, Nívea C. Saia, Thainá F. F. Jean-Baptiste, James Andrade Neto, Eugenio R. Fontes, Elizabeth P. B. |
author_sort | Breves, Sâmera S. |
collection | PubMed |
description | Begomoviruses, which belong to the Geminiviridae family, are intracellular parasites transmitted by whiteflies to dicotyledonous plants thatsignificantly damage agronomically relevant crops. These nucleus-replicating DNA viruses move intracellularly from the nucleus to the cytoplasm and then, like other plant viruses, cause disease by spreading systemically throughout the plant. The transport proteins of begomoviruses play a crucial role in recruiting host components for the movement of viral DNA within and between cells, while exhibiting functions that suppress the host’s immune defense. Pioneering studies on species of the Begomovirus genus have identified specific viral transport proteins involved in intracellular transport, cell-to-cell movement, and systemic spread. Recent research has primarily focused on viral movement proteins and their interactions with the cellular host transport machinery, which has significantly expanded understanding on viral infection pathways. This review focuses on three components within this context: (i) the role of viral transport proteins, specifically movement proteins (MPs) and nuclear shuttle proteins (NSPs), (ii) their ability to recruit host factors for intra- and intercellular viral movement, and (iii) the suppression of antiviral immunity, with a particular emphasis on bipartite begomoviral movement proteins. |
format | Online Article Text |
id | pubmed-10384534 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-103845342023-07-30 Begomovirus–Host Interactions: Viral Proteins Orchestrating Intra and Intercellular Transport of Viral DNA While Suppressing Host Defense Mechanisms Breves, Sâmera S. Silva, Fredy A. Euclydes, Nívea C. Saia, Thainá F. F. Jean-Baptiste, James Andrade Neto, Eugenio R. Fontes, Elizabeth P. B. Viruses Review Begomoviruses, which belong to the Geminiviridae family, are intracellular parasites transmitted by whiteflies to dicotyledonous plants thatsignificantly damage agronomically relevant crops. These nucleus-replicating DNA viruses move intracellularly from the nucleus to the cytoplasm and then, like other plant viruses, cause disease by spreading systemically throughout the plant. The transport proteins of begomoviruses play a crucial role in recruiting host components for the movement of viral DNA within and between cells, while exhibiting functions that suppress the host’s immune defense. Pioneering studies on species of the Begomovirus genus have identified specific viral transport proteins involved in intracellular transport, cell-to-cell movement, and systemic spread. Recent research has primarily focused on viral movement proteins and their interactions with the cellular host transport machinery, which has significantly expanded understanding on viral infection pathways. This review focuses on three components within this context: (i) the role of viral transport proteins, specifically movement proteins (MPs) and nuclear shuttle proteins (NSPs), (ii) their ability to recruit host factors for intra- and intercellular viral movement, and (iii) the suppression of antiviral immunity, with a particular emphasis on bipartite begomoviral movement proteins. MDPI 2023-07-21 /pmc/articles/PMC10384534/ /pubmed/37515277 http://dx.doi.org/10.3390/v15071593 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Breves, Sâmera S. Silva, Fredy A. Euclydes, Nívea C. Saia, Thainá F. F. Jean-Baptiste, James Andrade Neto, Eugenio R. Fontes, Elizabeth P. B. Begomovirus–Host Interactions: Viral Proteins Orchestrating Intra and Intercellular Transport of Viral DNA While Suppressing Host Defense Mechanisms |
title | Begomovirus–Host Interactions: Viral Proteins Orchestrating Intra and Intercellular Transport of Viral DNA While Suppressing Host Defense Mechanisms |
title_full | Begomovirus–Host Interactions: Viral Proteins Orchestrating Intra and Intercellular Transport of Viral DNA While Suppressing Host Defense Mechanisms |
title_fullStr | Begomovirus–Host Interactions: Viral Proteins Orchestrating Intra and Intercellular Transport of Viral DNA While Suppressing Host Defense Mechanisms |
title_full_unstemmed | Begomovirus–Host Interactions: Viral Proteins Orchestrating Intra and Intercellular Transport of Viral DNA While Suppressing Host Defense Mechanisms |
title_short | Begomovirus–Host Interactions: Viral Proteins Orchestrating Intra and Intercellular Transport of Viral DNA While Suppressing Host Defense Mechanisms |
title_sort | begomovirus–host interactions: viral proteins orchestrating intra and intercellular transport of viral dna while suppressing host defense mechanisms |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10384534/ https://www.ncbi.nlm.nih.gov/pubmed/37515277 http://dx.doi.org/10.3390/v15071593 |
work_keys_str_mv | AT brevessameras begomovirushostinteractionsviralproteinsorchestratingintraandintercellulartransportofviraldnawhilesuppressinghostdefensemechanisms AT silvafredya begomovirushostinteractionsviralproteinsorchestratingintraandintercellulartransportofviraldnawhilesuppressinghostdefensemechanisms AT euclydesniveac begomovirushostinteractionsviralproteinsorchestratingintraandintercellulartransportofviraldnawhilesuppressinghostdefensemechanisms AT saiathainaff begomovirushostinteractionsviralproteinsorchestratingintraandintercellulartransportofviraldnawhilesuppressinghostdefensemechanisms AT jeanbaptistejames begomovirushostinteractionsviralproteinsorchestratingintraandintercellulartransportofviraldnawhilesuppressinghostdefensemechanisms AT andradenetoeugenior begomovirushostinteractionsviralproteinsorchestratingintraandintercellulartransportofviraldnawhilesuppressinghostdefensemechanisms AT fonteselizabethpb begomovirushostinteractionsviralproteinsorchestratingintraandintercellulartransportofviraldnawhilesuppressinghostdefensemechanisms |