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Mouse Models for Human Herpesviruses

More than one hundred herpesviruses have been isolated from different species so far, with nine infecting humans. Infections with herpesviruses are characterized by life-long latency and represent a significant challenge for human health. To investigate the consequences of infections and identify no...

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Autores principales: Kutle, Ivana, Dittrich, Anne, Wirth, Dagmar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10384569/
https://www.ncbi.nlm.nih.gov/pubmed/37513800
http://dx.doi.org/10.3390/pathogens12070953
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author Kutle, Ivana
Dittrich, Anne
Wirth, Dagmar
author_facet Kutle, Ivana
Dittrich, Anne
Wirth, Dagmar
author_sort Kutle, Ivana
collection PubMed
description More than one hundred herpesviruses have been isolated from different species so far, with nine infecting humans. Infections with herpesviruses are characterized by life-long latency and represent a significant challenge for human health. To investigate the consequences of infections and identify novel treatment options, in vivo models are of particular relevance. The mouse has emerged as an economical small animal model to investigate herpesvirus infections. However, except for herpes simplex viruses (HSV-1, HSV-2), human herpesviruses cannot infect mice. Three natural herpesviruses have been identified in mice: mouse-derived cytomegalovirus (MCMV), mouse herpesvirus 68 (MHV-68), and mouse roseolovirus (MRV). These orthologues are broadly used to investigate herpesvirus infections within the natural host. In the last few decades, immunocompromised mouse models have been developed, allowing the functional engraftment of various human cells and tissues. These xenograft mice represent valuable model systems to investigate human-restricted viruses, making them particularly relevant for herpesvirus research. In this review, we describe the various mouse models used to study human herpesviruses, thereby highlighting their potential and limitations. Emphasis is laid on xenograft mouse models, covering the development and refinement of immune-compromised mice and their application in herpesvirus research.
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spelling pubmed-103845692023-07-30 Mouse Models for Human Herpesviruses Kutle, Ivana Dittrich, Anne Wirth, Dagmar Pathogens Review More than one hundred herpesviruses have been isolated from different species so far, with nine infecting humans. Infections with herpesviruses are characterized by life-long latency and represent a significant challenge for human health. To investigate the consequences of infections and identify novel treatment options, in vivo models are of particular relevance. The mouse has emerged as an economical small animal model to investigate herpesvirus infections. However, except for herpes simplex viruses (HSV-1, HSV-2), human herpesviruses cannot infect mice. Three natural herpesviruses have been identified in mice: mouse-derived cytomegalovirus (MCMV), mouse herpesvirus 68 (MHV-68), and mouse roseolovirus (MRV). These orthologues are broadly used to investigate herpesvirus infections within the natural host. In the last few decades, immunocompromised mouse models have been developed, allowing the functional engraftment of various human cells and tissues. These xenograft mice represent valuable model systems to investigate human-restricted viruses, making them particularly relevant for herpesvirus research. In this review, we describe the various mouse models used to study human herpesviruses, thereby highlighting their potential and limitations. Emphasis is laid on xenograft mouse models, covering the development and refinement of immune-compromised mice and their application in herpesvirus research. MDPI 2023-07-19 /pmc/articles/PMC10384569/ /pubmed/37513800 http://dx.doi.org/10.3390/pathogens12070953 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Kutle, Ivana
Dittrich, Anne
Wirth, Dagmar
Mouse Models for Human Herpesviruses
title Mouse Models for Human Herpesviruses
title_full Mouse Models for Human Herpesviruses
title_fullStr Mouse Models for Human Herpesviruses
title_full_unstemmed Mouse Models for Human Herpesviruses
title_short Mouse Models for Human Herpesviruses
title_sort mouse models for human herpesviruses
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10384569/
https://www.ncbi.nlm.nih.gov/pubmed/37513800
http://dx.doi.org/10.3390/pathogens12070953
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