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An Analysis of Respiratory Muscle Paralysis of Adult Patients in Guillain–Barré Syndrome: A Retrospective Analysis

Respiratory muscle paralysis is known as a very common complication of Guillain–Barré syndrome (GBS). However, most research has focused on its later stages rather than its earlier stages, including the prognosis of patients with this condition, or factors that act as early predictors of risk. There...

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Autores principales: Wang, Anqi, Wang, Xiaojing, Wang, Xinrui, Li, Guozhong, Zhong, Di
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10384571/
https://www.ncbi.nlm.nih.gov/pubmed/37512077
http://dx.doi.org/10.3390/medicina59071267
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author Wang, Anqi
Wang, Xiaojing
Wang, Xinrui
Li, Guozhong
Zhong, Di
author_facet Wang, Anqi
Wang, Xiaojing
Wang, Xinrui
Li, Guozhong
Zhong, Di
author_sort Wang, Anqi
collection PubMed
description Respiratory muscle paralysis is known as a very common complication of Guillain–Barré syndrome (GBS). However, most research has focused on its later stages rather than its earlier stages, including the prognosis of patients with this condition, or factors that act as early predictors of risk. Therefore, our study aimed to identify early predictors of respiratory muscle paralysis in patients with GBS and determine the short-term prognosis of such patients. We recruited 455 GBS patients (age ≥ 18) who had been hospitalized in the First Affiliated Hospital of Harbin Medical University between 2016 and 2021, retrospectively. We recorded clinical and laboratory data and used linear and logistic regression analysis to investigate the relationship between early clinical, examination results, and subsequent respiratory muscle paralysis. Among the 455 patients, 129 were assigned to a respiratory muscle paralysis group and 326 were assigned to a non-respiratory muscle paralysis group. Compared with the non-affected group, the time from onset to admission was shorter (p = 0.0003), and the Medical Research Council (MRC) score at admission and discharge was smaller in the affected group (p < 0.0001). Compared with the non-affected group, the affected group had higher Hughes and Erasmus GBS Respiratory Insufficiency Score (EGRIS) scores at admission and longer hospital stays (p < 0.0001). Patients in the affected group were more likely to have bulbar palsy and lung infections (p < 0.0001). To conclude, bulbar palsy, a higher EGRIS score and Hughes score at admission, a lower MRC score, and a shorter time between onset and admission, are all predictive risk factors for respiratory muscle paralysis in patients with GBS. An increase in any of these factors increases the risk of muscle paralysis. Patients with respiratory muscle paralysis have a poorer short-term prognosis than those without respiratory muscle paralysis. Therefore, we should attempt to identify patients with one or more of these characteristics in the early stages of admission, provide ventilation management, and administer IMV treatment if necessary.
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spelling pubmed-103845712023-07-30 An Analysis of Respiratory Muscle Paralysis of Adult Patients in Guillain–Barré Syndrome: A Retrospective Analysis Wang, Anqi Wang, Xiaojing Wang, Xinrui Li, Guozhong Zhong, Di Medicina (Kaunas) Article Respiratory muscle paralysis is known as a very common complication of Guillain–Barré syndrome (GBS). However, most research has focused on its later stages rather than its earlier stages, including the prognosis of patients with this condition, or factors that act as early predictors of risk. Therefore, our study aimed to identify early predictors of respiratory muscle paralysis in patients with GBS and determine the short-term prognosis of such patients. We recruited 455 GBS patients (age ≥ 18) who had been hospitalized in the First Affiliated Hospital of Harbin Medical University between 2016 and 2021, retrospectively. We recorded clinical and laboratory data and used linear and logistic regression analysis to investigate the relationship between early clinical, examination results, and subsequent respiratory muscle paralysis. Among the 455 patients, 129 were assigned to a respiratory muscle paralysis group and 326 were assigned to a non-respiratory muscle paralysis group. Compared with the non-affected group, the time from onset to admission was shorter (p = 0.0003), and the Medical Research Council (MRC) score at admission and discharge was smaller in the affected group (p < 0.0001). Compared with the non-affected group, the affected group had higher Hughes and Erasmus GBS Respiratory Insufficiency Score (EGRIS) scores at admission and longer hospital stays (p < 0.0001). Patients in the affected group were more likely to have bulbar palsy and lung infections (p < 0.0001). To conclude, bulbar palsy, a higher EGRIS score and Hughes score at admission, a lower MRC score, and a shorter time between onset and admission, are all predictive risk factors for respiratory muscle paralysis in patients with GBS. An increase in any of these factors increases the risk of muscle paralysis. Patients with respiratory muscle paralysis have a poorer short-term prognosis than those without respiratory muscle paralysis. Therefore, we should attempt to identify patients with one or more of these characteristics in the early stages of admission, provide ventilation management, and administer IMV treatment if necessary. MDPI 2023-07-07 /pmc/articles/PMC10384571/ /pubmed/37512077 http://dx.doi.org/10.3390/medicina59071267 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Wang, Anqi
Wang, Xiaojing
Wang, Xinrui
Li, Guozhong
Zhong, Di
An Analysis of Respiratory Muscle Paralysis of Adult Patients in Guillain–Barré Syndrome: A Retrospective Analysis
title An Analysis of Respiratory Muscle Paralysis of Adult Patients in Guillain–Barré Syndrome: A Retrospective Analysis
title_full An Analysis of Respiratory Muscle Paralysis of Adult Patients in Guillain–Barré Syndrome: A Retrospective Analysis
title_fullStr An Analysis of Respiratory Muscle Paralysis of Adult Patients in Guillain–Barré Syndrome: A Retrospective Analysis
title_full_unstemmed An Analysis of Respiratory Muscle Paralysis of Adult Patients in Guillain–Barré Syndrome: A Retrospective Analysis
title_short An Analysis of Respiratory Muscle Paralysis of Adult Patients in Guillain–Barré Syndrome: A Retrospective Analysis
title_sort analysis of respiratory muscle paralysis of adult patients in guillain–barré syndrome: a retrospective analysis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10384571/
https://www.ncbi.nlm.nih.gov/pubmed/37512077
http://dx.doi.org/10.3390/medicina59071267
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