Estimation of the risk of secondary cancer in rectum and bladder after radiation therapy for prostate cancer using a feasibility dose–volume histogram

We investigated the risk of secondary cancers in rectum and bladder for prostate cancer radiotherapy using a feasibility assessment tool. We calculated the risk of secondary cancer by generating a dose-volume histogram based on an ideal dose falloff function (f-value). This study found a smaller f-v...

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Detalles Bibliográficos
Autores principales: Aoyama, Takahiro, Shimizu, Hidetoshi, Koide, Yutaro, Kitagawa, Tomoki, Tachibana, Hiroyuki, Suzuki, Kojiro, Kodaira, Takeshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Technical Note
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10384607/
https://www.ncbi.nlm.nih.gov/pubmed/37520638
http://dx.doi.org/10.1016/j.phro.2023.100468
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author Aoyama, Takahiro
Shimizu, Hidetoshi
Koide, Yutaro
Kitagawa, Tomoki
Tachibana, Hiroyuki
Suzuki, Kojiro
Kodaira, Takeshi
author_facet Aoyama, Takahiro
Shimizu, Hidetoshi
Koide, Yutaro
Kitagawa, Tomoki
Tachibana, Hiroyuki
Suzuki, Kojiro
Kodaira, Takeshi
author_sort Aoyama, Takahiro
collection PubMed
description We investigated the risk of secondary cancers in rectum and bladder for prostate cancer radiotherapy using a feasibility assessment tool. We calculated the risk of secondary cancer by generating a dose-volume histogram based on an ideal dose falloff function (f-value). This study found a smaller f-value was associated with a lower secondary cancer risk in the rectum but a higher risk in the bladder. The study suggests setting the f-value at 0-0.1 as the optimization goal for the rectum and 0.4 for the bladder is reasonable and feasible for reducing the risk of secondary cancer and other adverse events.
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spelling pubmed-103846072023-07-30 Estimation of the risk of secondary cancer in rectum and bladder after radiation therapy for prostate cancer using a feasibility dose–volume histogram Aoyama, Takahiro Shimizu, Hidetoshi Koide, Yutaro Kitagawa, Tomoki Tachibana, Hiroyuki Suzuki, Kojiro Kodaira, Takeshi Phys Imaging Radiat Oncol Technical Note We investigated the risk of secondary cancers in rectum and bladder for prostate cancer radiotherapy using a feasibility assessment tool. We calculated the risk of secondary cancer by generating a dose-volume histogram based on an ideal dose falloff function (f-value). This study found a smaller f-value was associated with a lower secondary cancer risk in the rectum but a higher risk in the bladder. The study suggests setting the f-value at 0-0.1 as the optimization goal for the rectum and 0.4 for the bladder is reasonable and feasible for reducing the risk of secondary cancer and other adverse events. Elsevier 2023-07-05 /pmc/articles/PMC10384607/ /pubmed/37520638 http://dx.doi.org/10.1016/j.phro.2023.100468 Text en © 2023 The Authors https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Technical Note
Aoyama, Takahiro
Shimizu, Hidetoshi
Koide, Yutaro
Kitagawa, Tomoki
Tachibana, Hiroyuki
Suzuki, Kojiro
Kodaira, Takeshi
Estimation of the risk of secondary cancer in rectum and bladder after radiation therapy for prostate cancer using a feasibility dose–volume histogram
title Estimation of the risk of secondary cancer in rectum and bladder after radiation therapy for prostate cancer using a feasibility dose–volume histogram
title_full Estimation of the risk of secondary cancer in rectum and bladder after radiation therapy for prostate cancer using a feasibility dose–volume histogram
title_fullStr Estimation of the risk of secondary cancer in rectum and bladder after radiation therapy for prostate cancer using a feasibility dose–volume histogram
title_full_unstemmed Estimation of the risk of secondary cancer in rectum and bladder after radiation therapy for prostate cancer using a feasibility dose–volume histogram
title_short Estimation of the risk of secondary cancer in rectum and bladder after radiation therapy for prostate cancer using a feasibility dose–volume histogram
title_sort estimation of the risk of secondary cancer in rectum and bladder after radiation therapy for prostate cancer using a feasibility dose–volume histogram
topic Technical Note
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10384607/
https://www.ncbi.nlm.nih.gov/pubmed/37520638
http://dx.doi.org/10.1016/j.phro.2023.100468
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