Four Meroterpenoids with Novel Aminoglycoside Moiety from the Basidiomycete Clitocybe clavipes with Cytotoxic Activity

Four new meroterpenoids, Clavilactone M-P, possessing novel aminoglycoside moiety (1–4) and a 10-membered carbocycle fused with an α,β-epoxy-γ-lactone, were isolated from Clitocybe clavipes, a basidiomycete. Their structures with absolute configurations were determined by extensive analysis of their...

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Autores principales: Sun, Zhonghao, Ma, Yongben, Zhang, Jiawen, Ma, Guoxu, Wu, Haifeng, Shi, Leiling, Sun, Zhaocui, Xu, Xudong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10384625/
https://www.ncbi.nlm.nih.gov/pubmed/37513328
http://dx.doi.org/10.3390/molecules28145456
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author Sun, Zhonghao
Ma, Yongben
Zhang, Jiawen
Ma, Guoxu
Wu, Haifeng
Shi, Leiling
Sun, Zhaocui
Xu, Xudong
author_facet Sun, Zhonghao
Ma, Yongben
Zhang, Jiawen
Ma, Guoxu
Wu, Haifeng
Shi, Leiling
Sun, Zhaocui
Xu, Xudong
author_sort Sun, Zhonghao
collection PubMed
description Four new meroterpenoids, Clavilactone M-P, possessing novel aminoglycoside moiety (1–4) and a 10-membered carbocycle fused with an α,β-epoxy-γ-lactone, were isolated from Clitocybe clavipes, a basidiomycete. Their structures with absolute configurations were determined by extensive analysis of their spectroscopic data, and the ECD method. All the isolated compounds (1–4) were evaluated for their antitumor activity against three human cancer cell lines using the MTT assay. Compound 1 and 2 exhibited a significant suppression of cell viability in the Hela (IC(50) = 22.8 and 19.7 μM) cell line.
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spelling pubmed-103846252023-07-30 Four Meroterpenoids with Novel Aminoglycoside Moiety from the Basidiomycete Clitocybe clavipes with Cytotoxic Activity Sun, Zhonghao Ma, Yongben Zhang, Jiawen Ma, Guoxu Wu, Haifeng Shi, Leiling Sun, Zhaocui Xu, Xudong Molecules Article Four new meroterpenoids, Clavilactone M-P, possessing novel aminoglycoside moiety (1–4) and a 10-membered carbocycle fused with an α,β-epoxy-γ-lactone, were isolated from Clitocybe clavipes, a basidiomycete. Their structures with absolute configurations were determined by extensive analysis of their spectroscopic data, and the ECD method. All the isolated compounds (1–4) were evaluated for their antitumor activity against three human cancer cell lines using the MTT assay. Compound 1 and 2 exhibited a significant suppression of cell viability in the Hela (IC(50) = 22.8 and 19.7 μM) cell line. MDPI 2023-07-17 /pmc/articles/PMC10384625/ /pubmed/37513328 http://dx.doi.org/10.3390/molecules28145456 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Sun, Zhonghao
Ma, Yongben
Zhang, Jiawen
Ma, Guoxu
Wu, Haifeng
Shi, Leiling
Sun, Zhaocui
Xu, Xudong
Four Meroterpenoids with Novel Aminoglycoside Moiety from the Basidiomycete Clitocybe clavipes with Cytotoxic Activity
title Four Meroterpenoids with Novel Aminoglycoside Moiety from the Basidiomycete Clitocybe clavipes with Cytotoxic Activity
title_full Four Meroterpenoids with Novel Aminoglycoside Moiety from the Basidiomycete Clitocybe clavipes with Cytotoxic Activity
title_fullStr Four Meroterpenoids with Novel Aminoglycoside Moiety from the Basidiomycete Clitocybe clavipes with Cytotoxic Activity
title_full_unstemmed Four Meroterpenoids with Novel Aminoglycoside Moiety from the Basidiomycete Clitocybe clavipes with Cytotoxic Activity
title_short Four Meroterpenoids with Novel Aminoglycoside Moiety from the Basidiomycete Clitocybe clavipes with Cytotoxic Activity
title_sort four meroterpenoids with novel aminoglycoside moiety from the basidiomycete clitocybe clavipes with cytotoxic activity
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10384625/
https://www.ncbi.nlm.nih.gov/pubmed/37513328
http://dx.doi.org/10.3390/molecules28145456
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