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Increased In Vivo Exposure of N-(4-Hydroxyphenyl) Retinamide (4-HPR) to Achieve Plasma Concentrations Effective against Dengue Virus

N-(4-hydroxyphenyl) retinamide (4-HPR, or fenretinide) has promising in vitro and in vivo antiviral activity against a range of flaviviruses and an established safety record, but there are challenges to its clinical use. This study evaluated the in vivo exposure profile of a 4-HPR dosage regime prev...

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Detalles Bibliográficos
Autores principales:	Martin, Alexander J., Shackleford, David M., Charman, Susan A., Wagstaff, Kylie M., Porter, Christopher J. H., Jans, David A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10384639/ https://www.ncbi.nlm.nih.gov/pubmed/37514160 http://dx.doi.org/10.3390/pharmaceutics15071974

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