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Application of Cyclodextrin for Cancer Immunotherapy

Tumor immunotherapy, compared with other treatment strategies, has the notable advantage of a long-term therapeutic effect for preventing metastasis and the recurrence of tumors, thus holding great potential for the future of advanced tumor therapy. However, due to the poor water solubility of immun...

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Detalles Bibliográficos
Autores principales: Wei, Xiaojie, Yu, Cui-Yun, Wei, Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10384645/
https://www.ncbi.nlm.nih.gov/pubmed/37513483
http://dx.doi.org/10.3390/molecules28145610
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author Wei, Xiaojie
Yu, Cui-Yun
Wei, Hua
author_facet Wei, Xiaojie
Yu, Cui-Yun
Wei, Hua
author_sort Wei, Xiaojie
collection PubMed
description Tumor immunotherapy, compared with other treatment strategies, has the notable advantage of a long-term therapeutic effect for preventing metastasis and the recurrence of tumors, thus holding great potential for the future of advanced tumor therapy. However, due to the poor water solubility of immune modulators and immune escape properties of tumor cells, the treatment efficiency of immunotherapy is usually significantly reduced. Cyclodextrin (CD) has been repeatedly highlighted to be probably one of the most investigated building units for cancer therapy due to its elegant integration of an internal hydrophobic hollow cavity and an external hydrophilic outer surface. The application of CD for immunotherapy provides new opportunities for overcoming the aforementioned obstacles. However, there are few published reviews, to our knowledge, summarizing the use of CD for cancer immunotherapy. For this purpose, this paper provides a comprehensive summary on the application of CD for immunotherapy with an emphasis on the role, function, and reported strategies of CD in mediating immunotherapy. This review summarizes the research progress made in using CD for tumor immunotherapy, which will facilitate the generation of various CD-based immunotherapeutic delivery systems with superior anticancer efficacy.
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spelling pubmed-103846452023-07-30 Application of Cyclodextrin for Cancer Immunotherapy Wei, Xiaojie Yu, Cui-Yun Wei, Hua Molecules Review Tumor immunotherapy, compared with other treatment strategies, has the notable advantage of a long-term therapeutic effect for preventing metastasis and the recurrence of tumors, thus holding great potential for the future of advanced tumor therapy. However, due to the poor water solubility of immune modulators and immune escape properties of tumor cells, the treatment efficiency of immunotherapy is usually significantly reduced. Cyclodextrin (CD) has been repeatedly highlighted to be probably one of the most investigated building units for cancer therapy due to its elegant integration of an internal hydrophobic hollow cavity and an external hydrophilic outer surface. The application of CD for immunotherapy provides new opportunities for overcoming the aforementioned obstacles. However, there are few published reviews, to our knowledge, summarizing the use of CD for cancer immunotherapy. For this purpose, this paper provides a comprehensive summary on the application of CD for immunotherapy with an emphasis on the role, function, and reported strategies of CD in mediating immunotherapy. This review summarizes the research progress made in using CD for tumor immunotherapy, which will facilitate the generation of various CD-based immunotherapeutic delivery systems with superior anticancer efficacy. MDPI 2023-07-24 /pmc/articles/PMC10384645/ /pubmed/37513483 http://dx.doi.org/10.3390/molecules28145610 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Wei, Xiaojie
Yu, Cui-Yun
Wei, Hua
Application of Cyclodextrin for Cancer Immunotherapy
title Application of Cyclodextrin for Cancer Immunotherapy
title_full Application of Cyclodextrin for Cancer Immunotherapy
title_fullStr Application of Cyclodextrin for Cancer Immunotherapy
title_full_unstemmed Application of Cyclodextrin for Cancer Immunotherapy
title_short Application of Cyclodextrin for Cancer Immunotherapy
title_sort application of cyclodextrin for cancer immunotherapy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10384645/
https://www.ncbi.nlm.nih.gov/pubmed/37513483
http://dx.doi.org/10.3390/molecules28145610
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