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Serological Evaluation for Measles among Italian and Foreign Medical Students in a University Hospital in Rome

Background: Measles infection in the hospital setting is a major issue. Despite the availability of an effective vaccine, measles outbreaks continue to occur in some European countries. We aimed to evaluate the immunological status of medical students attending the Tor Vergata Polyclinic (PTV). Meth...

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Autores principales: Coppeta, Luca, Ferrari, Cristiana, Somma, Giuseppina, Giovinazzo, Viola, Buonomo, Ersilia, Trabucco Aurilio, Marco, Treglia, Michele, Magrini, Andrea
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10384754/
https://www.ncbi.nlm.nih.gov/pubmed/37515071
http://dx.doi.org/10.3390/vaccines11071256
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author Coppeta, Luca
Ferrari, Cristiana
Somma, Giuseppina
Giovinazzo, Viola
Buonomo, Ersilia
Trabucco Aurilio, Marco
Treglia, Michele
Magrini, Andrea
author_facet Coppeta, Luca
Ferrari, Cristiana
Somma, Giuseppina
Giovinazzo, Viola
Buonomo, Ersilia
Trabucco Aurilio, Marco
Treglia, Michele
Magrini, Andrea
author_sort Coppeta, Luca
collection PubMed
description Background: Measles infection in the hospital setting is a major issue. Despite the availability of an effective vaccine, measles outbreaks continue to occur in some European countries. We aimed to evaluate the immunological status of medical students attending the Tor Vergata Polyclinic (PTV). Methods: Measles antibodies titers were assessed by venipuncture on a sample of 2717 medical students who underwent annual health surveillance visits from January 2021 to March 2023. Subjects showing serum IgG values above 1.0 S/CO were considered serologically protected. Personal data, country of origin, and main demographic characteristic were also collected. Results: 66.7% (1467 Italian and 346 foreign) of medical students showed protective IgG antibodies levels. Female students were serologically immune more frequently than males (68.6% vs. 63.3%; p < 0.01 at Chi2). The mean antibody titer was 1.72 S/CO, significantly higher in females than males (1.67 vs. 1.75, respectively; p < 0.05), and significantly related to age (p < 0.01). Albanian students, who were the largest foreign population in our study, showed a low serological protection rate (40/90: 44.4%). Conclusions: The proportion of serologically non-immune students is high, raising concerns about the possible risk of hospital transmission. Substantial differences in the rate of immunity have been found between subjects coming from different parts of Europe and the world. Pre-training assessment of all medical students and vaccination of susceptible individuals is highly recommended, particularly for those from low immunization rate countries.
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spelling pubmed-103847542023-07-30 Serological Evaluation for Measles among Italian and Foreign Medical Students in a University Hospital in Rome Coppeta, Luca Ferrari, Cristiana Somma, Giuseppina Giovinazzo, Viola Buonomo, Ersilia Trabucco Aurilio, Marco Treglia, Michele Magrini, Andrea Vaccines (Basel) Article Background: Measles infection in the hospital setting is a major issue. Despite the availability of an effective vaccine, measles outbreaks continue to occur in some European countries. We aimed to evaluate the immunological status of medical students attending the Tor Vergata Polyclinic (PTV). Methods: Measles antibodies titers were assessed by venipuncture on a sample of 2717 medical students who underwent annual health surveillance visits from January 2021 to March 2023. Subjects showing serum IgG values above 1.0 S/CO were considered serologically protected. Personal data, country of origin, and main demographic characteristic were also collected. Results: 66.7% (1467 Italian and 346 foreign) of medical students showed protective IgG antibodies levels. Female students were serologically immune more frequently than males (68.6% vs. 63.3%; p < 0.01 at Chi2). The mean antibody titer was 1.72 S/CO, significantly higher in females than males (1.67 vs. 1.75, respectively; p < 0.05), and significantly related to age (p < 0.01). Albanian students, who were the largest foreign population in our study, showed a low serological protection rate (40/90: 44.4%). Conclusions: The proportion of serologically non-immune students is high, raising concerns about the possible risk of hospital transmission. Substantial differences in the rate of immunity have been found between subjects coming from different parts of Europe and the world. Pre-training assessment of all medical students and vaccination of susceptible individuals is highly recommended, particularly for those from low immunization rate countries. MDPI 2023-07-19 /pmc/articles/PMC10384754/ /pubmed/37515071 http://dx.doi.org/10.3390/vaccines11071256 Text en © 2023 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Coppeta, Luca
Ferrari, Cristiana
Somma, Giuseppina
Giovinazzo, Viola
Buonomo, Ersilia
Trabucco Aurilio, Marco
Treglia, Michele
Magrini, Andrea
Serological Evaluation for Measles among Italian and Foreign Medical Students in a University Hospital in Rome
title Serological Evaluation for Measles among Italian and Foreign Medical Students in a University Hospital in Rome
title_full Serological Evaluation for Measles among Italian and Foreign Medical Students in a University Hospital in Rome
title_fullStr Serological Evaluation for Measles among Italian and Foreign Medical Students in a University Hospital in Rome
title_full_unstemmed Serological Evaluation for Measles among Italian and Foreign Medical Students in a University Hospital in Rome
title_short Serological Evaluation for Measles among Italian and Foreign Medical Students in a University Hospital in Rome
title_sort serological evaluation for measles among italian and foreign medical students in a university hospital in rome
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10384754/
https://www.ncbi.nlm.nih.gov/pubmed/37515071
http://dx.doi.org/10.3390/vaccines11071256
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